T lymphocyte responses in HIV-1 infection: implications for vaccine development

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

1997 • 2,989 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

Positive Effects of Combined Antiretroviral Therapy on CD4 ⁺ T Cell Homeostasis and Function in Advanced HIV Disease

1997 • 1,812 citations

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

1997 • 1,482 citations

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

1999 • 1,428 citations

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

1998 • 1,426 citations

HLA and HIV-1: Heterozygote Advantage and B*35 - Cw*04 Disadvantage

1999 • 1,229 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1996 • 1,041 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

1998 • 1,012 citations

Early establishment of a pool of latently infected, resting CD4 ⁺ T cells during primary HIV-1 infection

1998 • 811 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

1995 • 650 citations

Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease

1998 • 555 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers

1999 • 520 citations

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors

1995 • 519 citations

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

1998 • 434 citations

Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi.

1998 • 431 citations

Immunologic Responses Associated with 12 Weeks of Combination Antiretroviral Therapy Consisting of Zidovudine, Lamivudine, and Ritonavir: Results of AIDS Clinical Trials Group Protocol 315

1998 • 431 citations

Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.

1993 • 427 citations

Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4

1998 • 411 citations

Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1

1998 • 400 citations

Nef Interacts with the μ Subunit of Clathrin Adaptor Complexes and Reveals a Cryptic Sorting Signal in MHC I Molecules

1998 • 383 citations

Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

1999 • 356 citations

Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy

1999 • 350 citations

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

1997 • 345 citations

In vivo migration and function of transferred HIV-1-specific cytotoxic T cells

1999 • 341 citations

Alterations in the Immune Response of Human Immunodeficiency Virus (HIV)-Infected Subjects Treated with an HIV-Specific Protease Inhibitor, Ritonavir

1996 • 338 citations

Reduction of HIV Concentration During Acute Infection: Independence from a Specific Immune Response

1996 • 335 citations

β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1998 • 334 citations

Strong Cytotoxic T Cell and Weak Neutralizing Antibody Responses in a Subset of Persons with Stable Nonprogressing HIV Type 1 Infection

1996 • 331 citations

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

1998 • 282 citations

Frequency of Class I HLA-Restricted Anti-HIV CD8+ T Cells in Individuals Receiving Highly Active Antiretroviral Therapy (HAART)

1999 • 274 citations

Lack of Reactivation of Cytomegalovirus (CMV) Retinitis after Stopping CMV Maintenance Therapy in AIDS Patients with Sustained Elevations in CD4 T Cells in Response to Highly Active Antiretroviral Therapy

1998 • 241 citations

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.

1994 • 232 citations

Conserved T Cell Receptor Repertoire in Primary and Memory CD8 T Cell Responses to an Acute Viral Infection

1998 • 229 citations

Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection

1998 • 224 citations

Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes

1996 • 222 citations

Combined Genotypes of CCR5, CCR2, SDF1, and HLA Genes Can Predict the Long-Term Nonprogressor Status in Human Immunodeficiency Virus-1–Infected Individuals

1999 • 215 citations

Immunological and Virological Analyses of Persons Infected by Human Immunodeficiency Virus Type 1 while Participating in Trials of Recombinant gp120 Subunit Vaccines

1998 • 208 citations

Mother‐Child Class I HLA Concordance Increases Perinatal Human Immunodeficiency Virus Type 1 Transmission

1998 • 201 citations

Evasion of Cytotoxic T Lymphocyte (CTL) Responses by Nef-dependent Induction of Fas Ligand (CD95L) Expression on Simian Immunodeficiency Virus–infected Cells

1997 • 194 citations

Immune Responses to Human Immunodeficiency Virus (HIV) Type 1 Induced by Canarypox Expressing HIV‐1_Mngp120, HIV‐1_SF2Recombinant gp120, or Both Vaccines in Seronegative Adults

1998 • 194 citations

The Effect of Commencing Combination Antiretroviral Therapy Soon after Human Immunodeficiency Virus Type 1 Infection on Viral Replication and Antiviral Immune Responses

1999 • 181 citations

Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope.

1994 • 179 citations

HLA Class I Homozygosity Accelerates Disease Progression in Human Immunodeficiency Virus Type 1 Infection

1999 • 176 citations

Delivery of Multiple CD8 Cytotoxic T Cell Epitopes by DNA Vaccination

1998 • 169 citations

Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors.

1995 • 163 citations

Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled.

1977 • 161 citations

Induction of specific T-cell responses in HIV infection

1998 • 161 citations

Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.

1998 • 156 citations

Lack of infection in HIV-exposed individuals is associated with a strong CD8⁺cell noncytotoxic anti-HIV response

1999 • 153 citations

Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific

1998 • 150 citations

Augmentation and Suppression of Immune Responses to an HIV-1 DNA Vaccine by Plasmid Cytokine/Ig Administration

1998 • 150 citations

Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development

1997 • 150 citations

Antiviral Activity of the Proteasome on Incoming Human Immunodeficiency Virus Type 1

1998 • 149 citations

Recombinant Vaccine-Induced Protection against the Highly Pathogenic Simian Immunodeficiency Virus SIV_mac251: Dependence on Route of Challenge Exposure

1998 • 146 citations

Induction of Systemic and Mucosal Immune Responses to Human Immunodeficiency Virus Type 1 by a DNA Vaccine Formulated with QS-21 Saponin Adjuvant via Intramuscular and Intranasal Routes

1998 • 146 citations

B Cells Directly Tolerize CD8+ T Cells

1998 • 142 citations

HIV-1 Tat binds TAF_II250 and represses TAF_II250-dependent transcription of major histocompatibility class I genes

1998 • 136 citations

Activation of CD8⁺T lymphocytes through the T cell receptor turns on CD4 gene expression: Implications for HIV pathogenesis

1998 • 134 citations

Costimulation of Naive CD8+ Lymphocytes Induces CD4 Expression and Allows Human Immunodeficiency Virus Type 1 Infection

1998 • 118 citations

Dynamics of viral variants in HIV-1 Nef and specific cytotoxic T lymphocytes in vivo.

1996 • 114 citations

Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6 Envelope Protein

1998 • 111 citations

A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients

1998 • 109 citations

Highly active antiretroviral therapy during early HIV infection reverses T-cell activation and maturation abnormalities

1998 • 105 citations

Recombinant modified vaccinia virus Ankara–simian immunodeficiency virusgag polelicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer

1998 • 104 citations

Identification and characterization of multiple HLA-A24-restricted HIV-1 CTL epitopes: strong epitopes are derived from V regions of HIV-1.

1997 • 102 citations

HIV-1 Tat Inhibits Human Natural Killer Cell Function by Blocking L-Type Calcium Channels

1998 • 102 citations

Lack of Viral Escape and Defective In Vivo Activation of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes in Rapidly Progressive Infection

1999 • 94 citations

Selection of Virus Variants and Emergence of Virus Escape Mutants after Immunization with an Epitope Vaccine

1998 • 91 citations

Regulation of anti-HIV-1 activity of RANTES by heparan sulfate proteoglycans.

1997 • 87 citations

Cross-clade recognition of p55 by cytotoxic T lymphocytes in HIV-1 infection

1998 • 87 citations

Cytotoxic T Cells from Human Immunodeficiency Virus Type 2-Infected Patients Frequently Cross-React with Different Human Immunodeficiency Virus Type 1 Clades

1998 • 79 citations

Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: the Ariel Project for the Prevention of Transmission of HIV from Mother to Infant

1999 • 78 citations

Productive Infection of Neonatal CD8+ T Lymphocytes by HIV-1

1998 • 78 citations

Oral Immunization of Macaques with Attenuated Vaccine Virus Induces Protection against Vaginally Transmitted AIDS

1998 • 76 citations

Cytotoxic T Cell and Neutralizing Antibody Responses to Human Immunodeficiency Virus Type 1 Envelope with a Combination Vaccine Regimen

1998 • 74 citations

HIV type 1-specific helper T cells: a critical host defense.

1998 • 73 citations

Optimization of a peptide-based protocol employing IL-7 for in vitro restimulation of human cytotoxic T lymphocyte precursors

1997 • 73 citations

Genetic Evaluation of Suspected Cases of Transient HIV-1 Infection of Infants

1998 • 67 citations

Cutting Edge: Induction of Enhanced CTL-Dependent Protective Immunity In Vivo by N-End Rule Targeting of a Model Tumor Antigen

1999 • 66 citations

Cross‐Clade Cytotoxic T Cell Response to Human Immunodeficiency Virus Type 1 Proteins among HLA Disparate North Americans and Thais

1998 • 62 citations

Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy

1998 • 58 citations

Frequency of HLA allele-specific peptide motifs in HIV-1 proteins correlates with the allele’s association with relative rates of disease progression after HIV-1 infection

1997 • 56 citations

Safety and immunogenicity of a candidate therapeutic vaccine, p24 virus-like particle, combined with zidovudine, in asymptomatic subjects

1998 • 54 citations

Quantification of CD8⁺T Lymphocytes Responsive to Human Immunodeficiency Virus (HIV) Peptide Antigens in HIV‐Infected Patients and Seronegative Persons at High Risk for Recent HIV Exposure

1998 • 52 citations

A New Monoclonal Antibody, mAb 4A12, Identifies a Role for the Glycosaminoglycan (GAG) Binding Domain of RANTES in the Antiviral Effect against HIV-1 and Intracellular Ca2+ Signaling

1998 • 52 citations

Vaccine-induced cytotoxic T lymphocytes protect against retroviral challenge

1998 • 51 citations

Oligoclonal expansion of HIV-specific cytotoxic CD8 T lymphocytes in the skin of HIV-1-infected patients with cutaneous pseudolymphoma.

1998 • 46 citations

Cross-Clade Envelope Glycoprotein 160-Specific CD8⁺Cytotoxic T Lymphocyte Responses in Early HIV Type 1 Clade B Infection

1998 • 46 citations

Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen

1998 • 44 citations

Persistent HIV-1-Specific CTL Clonal Expansion Despite High Viral Burden Post In Utero HIV-1 Infection

1999 • 40 citations

Cytotoxic T-cell responses to HIV-1 reverse transcriptase, integrase and protease

1998 • 39 citations

Detection of HIV-1-Specific CTLs in the Semen of HIV-Infected Individuals

1998 • 36 citations

Recognition of Two Overlapping CTL Epitopes in HIV-1 p17 by CTL from a Long-Term Nonprogressing HIV-1-Infected Individual

1998 • 25 citations

Nonsynonymous Mutations within the Human Immunodeficiency Virus Type 1 pl7 Gene Are Clustered to Sequences Binding to the Host Human Leukocyte Antigen Class I Molecules

1998 • 17 citations

Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: Implications for HIV pathogenesis

1998 • 5 citations