Selection of Virus Variants and Emergence of Virus Escape Mutants after Immunization with an Epitope Vaccine

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1994 • 1,899 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

1995 • 750 citations

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

1997 • 696 citations

Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

1995 • 650 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors

1995 • 519 citations

Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.

1993 • 427 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

1995 • 383 citations

HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant

1993 • 368 citations

The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia

1997 • 282 citations

CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual.

1991 • 279 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes.

1989 • 258 citations

Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients.

1994 • 238 citations

Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus‐1‐infected mothers

1992 • 221 citations

Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques

1995 • 188 citations

Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.

1992 • 184 citations

Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.

1994 • 175 citations

Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys.

1991 • 171 citations

Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes.

1988 • 157 citations

Peripheral clonal deletion of antiviral memory CD8⁺ T cells

1993 • 96 citations

The gag-specific cytotoxic T lymphocytes in rhesus monkeys infected with the simian immunodeficiency virus of macaques.

1990 • 87 citations

In vivo persistence of a HIV‐1‐encoded HLA‐B27‐restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity

1991 • 78 citations

Cytotoxic T lymphocyte response against multiple simian immunodeficiency virusA (SIV) proteins in SIV-infected macaques.

1992 • 70 citations

Simian immunodeficiency virus as a model for vaccination against HIV. Induction in rhesus macaques of GAG- or NEF-specific cytotoxic T lymphocytes by lipopeptides.

1994 • 59 citations

Comparative efficiency of simple lipopeptide constructs for in vivo induction of virus-specific CTL

1996 • 56 citations

Env-specific CTL predominate in cats protected from feline immunodeficiency virus infection by vaccination.

1996 • 56 citations

Cytotoxic T lymphocytes (CTL) against a transforming gene product select for transformed cells with point mutations within sequences encoding CTL recognition epitopes.

1992 • 44 citations

HLA‐dependent variations in human immunodeficiency virus Nef protein alter peptide/HLA binding

1995 • 41 citations

Antagonism of vaccine-induced HIV-1-specific CD4+ T cells by primary HIV-1 infection: potential mechanism of vaccine failure.

1997 • 40 citations