Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

Herpes simplex virus turns off the TAP to evade host immunity

1995 • 736 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

A viral inhibitor of peptide transporters for antigen presentation

1995 • 599 citations

Antigenic oscillations and shifting immunodominance in HIV-1 infections

1995 • 325 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell

1995 • 266 citations

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1993 • 215 citations

Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors.

1995 • 163 citations

Fusion from without directed by human immunodeficiency virus particles

1994 • 153 citations

Constitutive endocytosis of HLA class I antigens requires a specific portion of the intracytoplasmic tail that shares structural features with other endocytosed molecules.

1989 • 142 citations

Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection.

1989 • 93 citations

The Role of Nef in the Replication Cycle of the Human and Simian Immunodeficiency Viruses

1994 • 88 citations

Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes

1987 • 82 citations

Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

1995 • 80 citations

Human and murine class I MHC antigens share conserved serine 335, the site of HLA phosphorylation in vivo.

1984 • 74 citations

Receptor-like nature of class I HLA: endocytosis via coated pits.

1988 • 71 citations

Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef

1993 • 66 citations

Downregulation of HLA Class I Antigens in HIV-1-Infected Cells

1989 • 64 citations

Virus-induced loss of class I MHC antigens from the surface of cells infected with myxoma virus and malignant rabbit fibroma virus.

1992 • 61 citations

Constitutive expression of human immunodeficiency virus (HIV) nef protein in human astrocytes does not influence basal or induced HIV long terminal repeat activity

1990 • 61 citations

The association between murine beta 2-microglobulin and HLA class I heavy chains results in serologically detectable conformational changes of both chains.

1985 • 55 citations

Modulation of major histocompatibility complex antigen expression by viral infection.

1994 • 53 citations

The HIV-1 nef gene acts as a positive viral infectivity factor

1994 • 47 citations

Why can't cytotoxic T cells handle HIV?

1995 • 32 citations