Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

1997 • 2,989 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia

1997 • 2,154 citations

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

1997 • 1,911 citations

Positive Effects of Combined Antiretroviral Therapy on CD4 ⁺ T Cell Homeostasis and Function in Advanced HIV Disease

1997 • 1,812 citations

Treatment of Human Immunodeficiency Virus Infection with Saquinavir, Zidovudine, and Zalcitabine

1996 • 758 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.

1990 • 436 citations

Toward an Understanding of the Correlates of Protective Immunity to HIV Infection

1996 • 421 citations

The Interleukin-2 Receptor γ Chain: Its Role in the Multiple Cytokine Receptor Complexes and T Cell Development in XSCID

1996 • 411 citations

Controlled Trial of Interleukin-2 Infusions in Patients Infected with the Human Immunodeficiency Virus

1996 • 406 citations

ESCAPE OF HUMAN IMMUNODEFICIENCY VIRUS FROM IMMUNE CONTROL

1997 • 331 citations

T cell clonal anergy

1997 • 257 citations

Interleukin 2 and its receptors: recent advances and new immunological functions

1996 • 241 citations

Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity.

1996 • 168 citations

Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.

1997 • 167 citations

Selective loss of T cell functions in different stages of HIV infection Early loss ofanti‐CD3‐induced T cell proliferation followed by decreased anti‐CD3‐induced cytotoxic T lymphocyte generation in AIDS‐related complex and AIDS

1990 • 149 citations

Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development

1995 • 143 citations

Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells.

1994 • 129 citations

Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production.

1996 • 125 citations

Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 (CD95)-induced apoptosis and preservation of a T helper 1 phenotype.

1997 • 123 citations

Structure and Function of Interleukin 4 and 5

1988 • 58 citations

HIV-1 infection induces a selective reduction in STAT5 protein expression.

1998 • 57 citations

Defective protein tyrosine phosphorylation and altered levels of p59^fyn and p56^ick in CD4 T cells from HIV-1 infected patients

1994 • 54 citations

Further Analysis of Interleukin-2 Receptor Subunit Expression on the Different Human Peripheral Blood Mononuclear Cell Subsets

1998 • 54 citations

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.

1996 • 53 citations

Cutting Edge: HIV-1 Infection Induces a Selective Reduction in STAT5 Protein Expression

1998 • 48 citations

Interleukin-2 production and response to exogenous interleukin-2 in a patient with the acquired immune deficiency syndrome (AIDS).

1984 • 41 citations

Expression of the IL-2 receptor gamma subunit in resting human CD4 T lymphocytes: mRNA is constitutively transcribed and the protein stored as an intracellular component

1997 • 39 citations

Functional role for the myeloid differentiation antigen CD14 in the activation of human monocytes by IL-2.

1997 • 31 citations

Control of the IL-2 responsiveness of B lymphocytes by IL-2 and IL-4.

1995 • 28 citations

Evidence for B cell-mediated activation of V delta 1+ T lymphocytes during progression of HIV infection.

1997 • 26 citations

Functional role for the myeloid differentiation antigen CD14 in the activation of human monocytes by IL-2.

1997 • 23 citations

The Interleukin-2 Receptor Subunit Expression and Function on Peripheral Blood Lymphocytes from HIV-Infected and Control Persons

1994 • 21 citations

Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men

1993 • 13 citations

Abnormal expression of IL-2Rβ (p70)-binding polypeptide on HIV-infected patients' cells

1992 • 10 citations

Interleukin‐2 receptor β and γ chain dysregulation during the inhibition of CD4 T cell activation by human immunodeficiency virus‐1 gp120

1997 • 7 citations

Structure and function of Interleukin 5

1995 • 3 citations