Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults

1993 • 3,829 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Current protocols in immunology

1992 • 1,464 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1996 • 1,041 citations

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene

1992 • 1,025 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

Pathogenicity of Live, Attenuated SIV After Mucosal Infection of Neonatal Macaques

1995 • 491 citations

Progesterone implants enhance SIV vaginal transmission and early virus load

1996 • 469 citations

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1994 • 401 citations

Vaccine protection by a triple deletion mutant of simian immunodeficiency virus

1996 • 325 citations

Oral Poliovirus Vaccine: History of Its Development and Use and Current Challenge to Eliminate Poliomyelitis from the World

1985 • 274 citations

Construction andIn VitroProperties of SIV_macMutants with Deletions in "Nonessential" Genes

1994 • 261 citations

Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells

1995 • 219 citations

Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques.

1990 • 215 citations

Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence

1995 • 179 citations

Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1

1997 • 179 citations

Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus

1995 • 173 citations

Temporal Analyses of Virus Replication, Immune Responses, and Efficacy in Rhesus Macaques Immunized with a Live, Attenuated Simian Immunodeficiency Virus Vaccine

1998 • 149 citations

Infection and AIDS in Adult Macaques After Nontraumatic Oral Exposure to Cell-Free SIV

1996 • 144 citations

Simian Immunodeficiency Virus/Delta-Induced Immunodeficiency Disease in Rhesus Monkeys: Relation of Antibody Response and Antigenemia

1988 • 117 citations

Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus

1997 • 114 citations

Genotypic selection of simian immunodeficiency virus in macaque infants infected transplacentally

1995 • 103 citations

Construction andIn VitroProperties of SIV_macMutants with Deletions in "Nonessential" Genes

1994 • 99 citations

Mucosal Infection of Neonatal Rhesus Monkeys with Cell-Free SIV

1994 • 88 citations

Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene

1994 • 80 citations

Protection from Pathogenic SIVmac Challenge Following Short-Term Infection with a Nef-Deficient Attenuated Virus

1996 • 76 citations

Effects of (R)-9-(2-Phosphonylmethoxypropyl)adenine Monotherapy on Chronic SIV Infection in Macaques

1997 • 67 citations

Murine and simian retrovirus models

1996 • 51 citations

Vaccines against Human Immunodeficiency Virus -- Progress and Prospects

1993 • 50 citations

Animal Models for Acquired Immunodeficiency Syndrome

1992 • 43 citations

Simian immunodeficiency virus infection via amniotic fluid: a model to study fetal immunopathogenesis and prophylaxis.

1993 • 41 citations

Lentivirus-induced Pulmonary Lesions in Rhesus Monkeys (Macaca mulatta) Infected with Simian Immunodeficiency Virus

1991 • 40 citations

Experimental Infection of Timed‐Pregnant Rhesus Monkeys With Simian Immunodeficiency Virus (SIV) During Early, Middle, and Late Gestation

1990 • 36 citations

Maternal–fetal transmission of SIV in macaques: Disseminated adenovirus infection in an offspring with congenital SIV infection

1991 • 36 citations

Immunological and Virological Changes Associated with Decline in CD4/CD8 Ratios in Lymphoid Organs of SIV-Infected Macaques

1994 • 32 citations

Simultaneous Detection of Simian Retrovirus Type D Serotypes 1, 2, and 3 by Polymerase Chain Reaction

1997 • 26 citations

Detection of Simian T Cell Leukemia Virus Type I Infection in Seronegative Macaques

1997 • 24 citations

Response : Attenuated Retrovirus Vaccines and AIDS

1995 • 8 citations