HLA and HIV-1: Heterozygote Advantage and B*35 - Cw*04 Disadvantage

Regression Models and Life-Tables

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In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

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HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

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Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

1988 • 1,968 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

Common West African HLA antigens are associated with protection from severe malaria

1991 • 1,570 citations

Genetic Data Analysis

1990 • 1,380 citations

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1996 • 1,041 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

Phototyping: comprehensive DNA typing for HLA‐A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence‐specific primers (PCR‐SSP)

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

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Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

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Genetic Basis for Species Vulnerability in the Cheetah

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Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex

1975 • 751 citations

HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

1995 • 750 citations

Fundamentals of Genetic Epidemiology

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Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci.

1990 • 688 citations

NATURAL SELECTION AT MAJOR HISTOCOMPATIBILITY COMPLEX LOCI OF VERTEBRATES

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Population Biology of Antigen Presentation by MHC Class I Molecules

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A Prospective Study of Human Immunodeficiency Virus Type 1 Infection and the Development of AIDS in Subjects with Hemophilia

1989 • 536 citations

Antigenic Diversity Thresholds and the Development of AIDS

1991 • 531 citations

Origin of major histocompatibility complex polymorphism: The trans-species hypothesis

1987 • 450 citations

Plots of P-values to evaluate many tests simultaneously

1982 • 439 citations

Association between an MHC Class II Allele and Clearance of Hepatitis B Virus in the Gambia

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Toward an Understanding of the Correlates of Protective Immunity to HIV Infection

1996 • 421 citations

Long-term HIV-1 infection without immunologic progression

1994 • 382 citations

HLA : genetic diversity of HLA functional and medical implication

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Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

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Strong Cytotoxic T Cell and Weak Neutralizing Antibody Responses in a Subset of Persons with Stable Nonprogressing HIV Type 1 Infection

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EVIDENCE FOR BALANCING SELECTION AT HLA

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Association of Malaria Parasite Population Structure, HLA, and Immunological Antagonism

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MOLECULAR TRANS-SPECIES POLYMORPHISM

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Hierarchical Control of Lymphocyte Survival

1996 • 255 citations

Immunobiology of HLA

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Acquired Immune Deficiency Syndrome Occurring Within 5 Years of Infection with Human Immunodeficiency Virus Type-1

1992 • 156 citations

Role of Cellular Immunity in Protection against HIV Infection**This article was accepted for publication on 31 October 1996.

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Hemophilia Growth and Development Study

1993 • 125 citations

Population Analysis on the Basis of Deduced Haplotypes from Random Families

1984 • 119 citations

HLA-B35 is associated with accelerated progression to AIDS.

1992 • 114 citations

Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone

1993 • 112 citations

Strong balancing selection at HLA loci: Evidence from segregation in South Amerindian families

1997 • 110 citations

Associations between HLA Frequencies and Pathogenic Features of Human Immunodeficiency Virus Type 1 Infection in Seroconverters from the Amsterdam Cohort of Homosexual Men

1994 • 109 citations

Host Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (∆32 CCR5)

1997 • 103 citations

Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes.

1991 • 102 citations

Evidence of presentation of multiple HIV-1 cytotoxic T lymphocyte epitopes by HLA-B*3501 molecules that are associated with the accelerated progression of AIDS.

1997 • 85 citations

A primate species with limited major histocompatibility complex class I polymorphism.

1988 • 66 citations

Clinical Progression of HIV Infection: Role of NK Cells

1997 • 66 citations

Identification of multiple HIV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules.

1996 • 64 citations

Progression to AIDS in French haemophiliacs

1993 • 54 citations

Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in hemophilic siblings

1995 • 47 citations

Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in hemophilic siblings

1995 • 42 citations

Cytotoxic T cells—protection from disease progression—protection from infection

1996 • 27 citations

EVOLUTIONARY BIOLOGY OF HUMAN IMMUNODEFICIENCY VIRUS

1994 • 26 citations

Polymorphic Hh genes in the HLA-B(C) region control natural killer cell frequency and activity.

1994 • 24 citations

Immunodominance of a single CTL epitope in a primate species with limited MHC class I polymorphism.

1997 • 22 citations

Characterization of 12 microsatellite loci of the human MHC in a panel of reference cell lines

1997 • 22 citations

14. Statistics And Population Genetics Of The HLA System

1989 • 4 citations

Automated methods of zygosity determination using fluorescent micro satellite markers

1995 • 1 citations