Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Reactive oxygen species in cell signaling

2000 • 2,844 citations

Cellular response to oxidative stress: Signaling for suicide and survival*

2002 • 2,258 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

The Role of Oxidative Stress in Carcinogenesis

2004 • 1,516 citations

Lipid hydroperoxide generation, turnover, and effector action in biological systems

1998 • 1,188 citations

Mechanisms of action of arsenic trioxide.

2002 • 943 citations

Oxidative Stress and Cell Signalling

2004 • 692 citations

Antioxidants: what role do they play in physical activity and health?

2000 • 687 citations

Metal-induced oxidative stress and signal transduction

2004 • 650 citations

ROS, stress‐activated kinases and stress signaling in cancer

2002 • 585 citations

Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches

2000 • 478 citations

Reactive Oxygen Species Generation and Mitochondrial Dysfunction in the Apoptotic Response to Bortezomib, a Novel Proteasome Inhibitor, in Human H460 Non-small Cell Lung Cancer Cells

2003 • 458 citations

Proteasome Inhibitor PS-341 Induces Apoptosis through Induction of Endoplasmic Reticulum Stress-Reactive Oxygen Species in Head and Neck Squamous Cell Carcinoma Cells

2004 • 429 citations

Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity

2004 • 388 citations

Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells

2003 • 329 citations

Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents

2003 • 322 citations

Oxidative Stress-mediated Apoptosis

2002 • 313 citations

Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress

2003 • 285 citations

Manganic Porphyrins Possess Catalase Activity and Protect Endothelial Cells against Hydrogen Peroxide-Mediated Injury

1997 • 284 citations

Arsenic induces oxidant stress and NF-KB activation in cultured aortic endothelial cells

1996 • 281 citations

Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases

2003 • 280 citations

Role of Reactive Oxygen Species and p53 in Chromium(VI)-induced Apoptosis

1999 • 268 citations

Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cellsElectronic supplementary information (ESI) available: Further experimental and crystallographic details. See http://www.rsc.org/suppdata/cc/b3/b303294a/

2003 • 267 citations

Oxidative stress and apoptosis in metal ion-induced carcinogenesis

2004 • 263 citations

Metalloporphyrin class of therapeutic catalytic antioxidants

1999 • 251 citations

The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects

2002 • 236 citations

Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani

2004 • 228 citations

Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells

2004 • 228 citations

Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger

1996 • 220 citations

In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

2003 • 217 citations

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

2001 • 194 citations

Gold(III) Porphyrin 1a Induced Apoptosis by Mitochondrial Death Pathways Related to Reactive Oxygen Species

2005 • 186 citations

Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine

2004 • 177 citations

Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells

2004 • 177 citations

1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage.

1999 • 164 citations

Metalloporphyrins are potent inhibitors of lipid peroxidation

1999 • 159 citations

DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation

2003 • 158 citations

Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin

2003 • 153 citations

Emodin Enhances Arsenic Trioxide-Induced Apoptosis via Generation of Reactive Oxygen Species and Inhibition of Survival Signaling

2004 • 149 citations

Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo

2000 • 145 citations

p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells

1998 • 143 citations

The molecular mechanisms of arsenic-induced cell transformation and apoptosis.

2002 • 122 citations

A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis

2004 • 121 citations

Camptothecin-induced Imbalance in Intracellular Cation Homeostasis Regulates Programmed Cell Death in Unicellular Hemoflagellate Leishmania donovani

2004 • 118 citations

Proapoptotic Activity of New Glutathione S-Transferase Inhibitors

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1989 • 106 citations

Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines

2004 • 104 citations

Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS.

2003 • 99 citations

A phase III study of irinotecan (CPT-11) versus best supportive care in patients with metastatic colorectal cancer who have failed 5-fluorouracil therapy. V301 Study Group.

1999 • 97 citations

Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway.

1999 • 95 citations

Role of reactive oxygen species in the induction of apoptosis by α‐tocopheryl succinate

2004 • 91 citations

Docosahexaenoic acid enhances arsenic trioxide–mediated apoptosis in arsenic trioxide–resistant HL-60 cells

2003 • 88 citations

Non-pungent capsaicinoids from sweet pepper

2003 • 87 citations

Prospective strategies to enforce selectively cell death in cancer cells

2004 • 83 citations

Proteomic characterization of the cytotoxic mechanism of gold (III) porphyrin 1a, a potential anticancer drug

2005 • 82 citations

Enhancement of arsenic trioxide‐mediated apoptosis using docosahexaenoic acid in arsenic trioxide‐resistant solid tumor cells

2004 • 80 citations

C-Myc Down-Regulation Increases Susceptibility to Cisplatin through Reactive Oxygen Species-Mediated Apoptosis in M14 Human Melanoma Cells

2001 • 79 citations

Chromium(III) Induced Abnormalities in Human Lymphocyte Cell Proliferation: Evidence for Apoptosis

1995 • 79 citations

Chromium(III)-induced apoptosis of lymphocytes: death decision by ROS and Src-family tyrosine kinases

2002 • 79 citations

Heme oxygenase‐1 protects against apoptosis induced by tumor necrosis factor‐α and cycloheximide in papillary thyroid carcinoma cells

2004 • 74 citations

Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis

2004 • 71 citations

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

2004 • 70 citations

Sulindac Enhances the Proteasome Inhibitor Bortezomib-Mediated Oxidative Stress and Anticancer Activity

2005 • 59 citations

Synergistic Effect of Histone Deacetylase Inhibitors FK228 and m-Carboxycinnamic Acid Bis-Hydroxamide with Proteasome Inhibitors PSI and PS-341 against Gastrointestinal Adenocarcinoma Cells

2004 • 59 citations

Vitamin D sensitizes breast cancer cells to the action of H2O2: Mitochondria as a convergence point in the death pathway

2005 • 49 citations

Signal transduction of p53-independent apoptotic pathway induced by hexavalent chromium in U937 cells

2004 • 44 citations

Vitamin D enhances caspase‐dependent and ‐independent TNFα‐induced breast cancer cell death: The role of reactive oxygen species and mitochondria

2003 • 44 citations

Apoptosis of lymphocytes induced by chromium(VI/V) is through ROS-mediated activation of Src-family kinases and caspase-3

2003 • 32 citations

Proteomic and biochemical analyses of in vitro carcinogen‐induced lung cell transformation: Synergism between arsenic and benzo[a]pyrene

2006 • 28 citations

Control of Heme Metabolism by Synthetic Metalloporphyrinsa

1987 • 28 citations

Effects of platinum and palladium ions on the production and reactivity of neutrophil-derived reactive oxygen species

2004 • 17 citations