Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway.

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

The Univalent Reduction of Oxygen by Reduced Flavins and Quinones

1972 • 418 citations

The cell-death machine

1996 • 351 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication.

1993 • 225 citations

Role of the Stress-activated/c-Jun NH2-terminal Protein Kinase Pathway in the Cellular Response to Adriamycin and Other Chemotherapeutic Drugs

1996 • 215 citations

beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin.

1993 • 212 citations

c-Jun NH2-terminal Kinase-mediated Activation of Interleukin-1β Converting Enzyme/CED-3-like Protease during Anticancer Drug-induced Apoptosis

1997 • 207 citations

Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.

1995 • 203 citations

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis

1995 • 189 citations

Yersinia enterocolitica Promotes Deactivation of Macrophage Mitogen-activated Protein Kinases Extracellular Signal-regulated Kinase-1/2, p38, and c-Jun NH2-terminal Kinase

1997 • 153 citations

Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones.

1997 • 149 citations

Induction of apoptosis by beta-lapachone in human prostate cancer cells.

1995 • 142 citations

Role of multiple cellular proteases in the execution of programmed cell death

1995 • 141 citations

.beta.-Lapachone: synthesis of derivatives and activities in tumor models

1984 • 113 citations

In vitroandin vivoevaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives againstTrypanosoma cruzi

1978 • 109 citations

Involvement of Hydrogen Peroxide in Topoisomerase Inhibitor β-lapachone-Induced Apoptosis and Differentiation in Human Leukemia Cells

1998 • 106 citations

Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: implications for cellular survival and tumor promotion.

1996 • 96 citations

The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2

1998 • 88 citations

β-lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by Sarcoma 180 ascites tumor cells

1979 • 75 citations

Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitor.

1987 • 75 citations

Regulation of Interleukin-2 Transcription by Inducible Stable Expression of Dominant Negative and Dominant Active Mitogen-activated Protein Kinase Kinase Kinase in Jurkat T Cells

1996 • 72 citations

β‐Lapachone, an Inhibitor of Oncornavirus Reverse Transcriptase and Eukaryotic DNA Polymerase‐α

1978 • 65 citations

Effects of β-lapachone, a peroxide-generating quinone, on macromolecule synthesis and degradation in Trypanosoma cruzi

1985 • 60 citations

β-Lapachone greatly enhances MMS lethality to human fibroblasts

1984 • 42 citations

Differential activation of the extracellular signal-regulated kinase, Jun Kinase and Janus Kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposiʼs sarcoma cells

1996 • 40 citations