Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

Superoxide dismutase as a target for the selective killing of cancer cells

2000 • 824 citations

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells

1997 • 808 citations

Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

1999 • 539 citations

Use of arsenic trioxide (As₂O₃) in the treatment of patients with acute promyelocytic leukemia

2003 • 496 citations

Overexpression of GlutathioneS-Transferase II and Multidrug Resistance Transport Proteins Is Associated with Acquired Tolerance to Inorganic Arsenic

2001 • 223 citations

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

2001 • 194 citations

l-S,R-buthionine sulfoximine: historical development and clinical issues

1998 • 172 citations

Phase I Study of Continuous-Infusion L-S,R-Buthionine Sulfoximine With Intravenous Melphalan

1997 • 161 citations

Arsenic trioxide sensitivity is associated with low level of glutathione in cancer cells

1999 • 131 citations

Reactive oxygen and nitrogen species: efficient, selective, and interactive signals during intercellular induction of apoptosis.

2001 • 102 citations

Arsenic Trioxide-Induced Apoptosis and Its Enhancement by Buthionine Sulfoximine in Hepatocellular Carcinoma Cell Lines

2002 • 76 citations

Antioxidant Enzymes In Malignant Prostate Cell Lines and In Primary Cultured Prostatic Cells

1997 • 73 citations

TNF-α AND IL-1α INDUCE APOPTOSIS IN SUBCONFLUENT RAT MESANGIAL CELLS. EVIDENCE FOR THE INVOLVEMENT OF HYDROGEN PEROXIDE AND LIPID PEROXIDATION AS SECOND MESSENGERS

2000 • 68 citations

Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.

2001 • 65 citations

Prostate-specific amplification of expanded polyglutamine expression: a novel approach for cancer gene therapy.

1998 • 42 citations

Effect of Calcium on Reactive Oxygen Species in Isolated Rat Cardiomyocytes During Hypoxia and Reoxygenation

2000 • 34 citations

CROP/Luc7A, a novel serine/arginine‐rich nuclear protein, isolated from cisplatin‐resistant cell line¹

2000 • 32 citations

Evidence for the association of ultraviolet-C and H2O2-induced apoptosis with acid sphingomyelinase activation

2001 • 26 citations

A New Nitric Oxide Scavenger, Imidazolineoxyl N-Oxide Derivative, and Its Effects in Pathophysiology and Microbiology

1995 • 22 citations

Rapid detection of candidate metastatic foci in the orthotopic inoculation model of androgen-sensitive prostate cancer cells introduced with green fluorescent protein

2000 • 22 citations

Multifactorial Involvement of Multidrug Resistance Protein, DNA Topoisomerase II and Glutathione/Glutathione‐S‐Transferase in NonP‐ Glycoprotein‐Mediated Multidrug Resistance in Human Bladder Cancer Cells

1997 • 13 citations