Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells

A simple technique for quantitation of low levels of DNA damage in individual cells

1988 • 10,537 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Naturally Occurring Quinones

1971 • 1,283 citations

Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

1999 • 829 citations

Free radical biology and medicine

2003 • 519 citations

A microplate assay for the detection of oxidative products using 2′,7′-dichlorofluorescin-diacetate

1992 • 517 citations

Human disease, free radicals, and the oxidant/antioxidant balance

1993 • 385 citations

The role of intracellular oxidants in apoptosis

1995 • 294 citations

Involvement of Reactive Oxygen Species in N-(4-Hydroxyphenyl)retinamide-Induced Apoptosis in Cervical Carcinoma Cells

1997 • 226 citations

Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9

2003 • 193 citations

Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats

1998 • 172 citations

Free radicals in pharmacology and toxicology--selected topics.

1981 • 167 citations

Stimulation of Topoisomerase II-Mediated DNA Damage via a Mechanism Involving Protein Thiolation

2001 • 154 citations

Plumbagin: A study of its anticancer, antibacterial & antifungal properties.

1980 • 150 citations

Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action

1989 • 129 citations

Menadione: Spectrum of anticancer activity and effects on nucleotide metabolism in human neoplastic cell lines

1991 • 105 citations

Nitric Oxide Sensitizes Ovarian Tumor Cells to Fas-Induced Apoptosis

1999 • 95 citations

Biological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis

1992 • 95 citations

Effects of plumbagin on reproductive function of male dog.

1984 • 76 citations

Vitamin K3 (menadione) inhibits the growth of mammalian tumor cells in culture

1981 • 72 citations

Menadione-induced DNA damage in a human tumor cell line

1991 • 68 citations

Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells

1999 • 62 citations

Exogenous quinones directly inhibit the respiratory NADH dehydrogenase in Escherichia coli

1992 • 62 citations

Cardiotonic Action of Plumbagin on Guinea-Pig Papillary Muscle

1991 • 59 citations

Caffeic acid phenethyl ester stimulates human antioxidant response element-mediated expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene.

1997 • 58 citations

Niosomal Plumbagin with Reduced Toxicity and Improved Anticancer Activity in BALB/C Mice

1996 • 58 citations

Antifertility activity of plumbagin.

1977 • 53 citations

Evidence for Thiol-Dependent Production of Oxygen Radicals by 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (Oltipraz) and 3H-1,2-Dithiole-3-thione: Possible Relevance to the Anticarcinogenic Properties of 1,2-Dithiole-3-thiones

1997 • 51 citations

Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1

2002 • 49 citations

Antisense blocking of BRCA1 enhances sensitivity to plumbagin but not tamoxifen in BG‐1 ovarian cancer cells

2003 • 45 citations

Antitumor and antifertility activities of plumbagin controlled release formulations.

1997 • 45 citations

1,2(3)-Tetrahydro-3,3′-biplumbagin: A naphthalenone and other constituents from Plumbago zeylanica

1983 • 44 citations

Reduced toxicity and enhanced antitumor efficacy of betacyclodextrin plumbagin inclusion complex in mice bearing Ehrlich ascites carcinoma.

1997 • 42 citations

Synergistic Effects of Some Pairs of Antioxidants and Related Agents on Mouse Leukaemia L5 178Y Cell Growth In-vitro

1998 • 16 citations

Induction of Quinone Reductase and Glutathione Transferase in Rat Tissues by Juglone and Plumbagin

2000 • 11 citations