Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Superoxide dismutase as a target for the selective killing of cancer cells

2000 • 824 citations

Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

2000 • 808 citations

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

1994 • 743 citations

Studies on Treatment of Acute Promyelocytic Leukemia With Arsenic Trioxide: Remission Induction, Follow-Up, and Molecular Monitoring in 11 Newly Diagnosed and 47 Relapsed Acute Promyelocytic Leukemia Patients

1999 • 630 citations

Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

1999 • 539 citations

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

1997 • 525 citations

Use of arsenic trioxide (As₂O₃) in the treatment of patients with acute promyelocytic leukemia

2003 • 496 citations

Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis

1998 • 473 citations

Mitochondrial Production of Superoxide Radical and Hydrogen Peroxide

1977 • 415 citations

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

1994 • 400 citations

Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells

1998 • 355 citations

Manganese Superoxide Dismutase Mediates the Early Release of Mitochondrial Cytochrome C and Subsequent DNA Fragmentation after Permanent Focal Cerebral Ischemia in Mice

1999 • 315 citations

Induction of apoptotic cell death in chronic lymphocytic leukemia by 2- chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine

1993 • 283 citations

Redox Regulation of the Caspases during Apoptosis^a

1998 • 271 citations

Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer.

2002 • 257 citations

An analysis of the role of coenzyme Q in free radical generation and as an antioxidant

1992 • 245 citations

Arsenite induces apoptosis in chinese hamster ovary cells by generation of reactive oxygen species

1996 • 241 citations

2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate.

2000 • 235 citations

Free radicals antioxidant enzymes and lipid peroxidation in different types of leukemias

2000 • 227 citations

Induction of apoptotic cell death in chronic lymphocytic leukemia by 2- chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine

1993 • 226 citations

2-Methoxyestradiol, an Endogenous Estrogen Metabolite, Induces Apoptosis in Endothelial Cells and Inhibits Angiogenesis: Possible Role for Stress-Activated Protein Kinase Signaling Pathway and Fas Expression

1997 • 193 citations

Synthesis, Antitubulin and Antimitotic Activity, and Cytotoxicity of Analogs of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite of Estradiol That Inhibits Tubulin Polymerization by Binding to the Colchicine Binding Site

1995 • 185 citations

Mitochondrial DNA determines the cellular response to cancer therapeutic agents

1999 • 180 citations

Mutagenic damage to mammalian cells by therapeutic alkylating agents

1996 • 149 citations

Generation of superoxide anion by mitochondria and impairment of their functions during anoxia and reoxygenation in vitro

1998 • 145 citations

Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol

1997 • 138 citations

Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines.

1999 • 119 citations

Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide

2001 • 116 citations

2-Methoxyestradiol Arrests Cells in Mitosis without Depolymerizing Tubulin

1996 • 110 citations

2-Methoxyestradiol Induces G2/M Arrest and Apoptosis in Prostate Cancer

2001 • 108 citations

The mammalian metabolite, 2-methoxyestradiol, affects p53 levels and apoptosis induction in transformed cells but not in normal cells

1997 • 100 citations

Superoxide dismutase: an emerging target for cancer therapeutics

2001 • 99 citations

Mitochondrial Superoxide Radical Formation is Controlled by Electron Bifurcation to the High and Low Potential Pathways

2002 • 94 citations

Molecular Targets of Arsenic Trioxide in Malignant Cells

2002 • 90 citations

Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine

2000 • 90 citations

2‐methoxyestradiol blocks cell‐cycle progression at G₂/M phase and inhibits growth of human prostate cancer cells

2001 • 88 citations

The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors

2001 • 87 citations

Ceramide Reduces Endothelium-Dependent Vasodilation by Increasing Superoxide Production in Small Bovine Coronary Arteries

2001 • 82 citations

Mutations in the mitochondrial DNA D-Loop region occur frequently in adenocarcinoma in Barrett's esophagus

2002 • 77 citations

Superinduction of wild-type p53 protein after 2-methoxyestradiol treatment of Ad5p53-transduced cells induces tumor cell apoptosis

1998 • 68 citations

Tissue Hypoxia and Ischemia

1977 • 64 citations

2-Methoxymethylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics

2001 • 61 citations

A Steroid Derivative with Paclitaxel-Like Effects on Tubulin Polymerization

2000 • 60 citations

2-Methoxyestradiol blocks estrogen-induced rat pituitary tumor growth and tumor angiogenesis: possible role of vascular endothelial growth factor.

2000 • 53 citations

An agent that increases tumor suppressor transgene product coupled with systemic transgene delivery inhibits growth of metastatic lung cancer in vivo.

1998 • 52 citations

Evidence against the Generation of Free Hydroxyl Radicals from the Interaction of Copper,Zinc-Superoxide Dismutase and Hydrogen Peroxide

1999 • 52 citations

2-methoxyestradiol-induced caspase-3 activation and apoptosis occurs through G2/M arrest dependent and independent pathways in gastric carcinoma cells

2001 • 48 citations

2-methoxyestradiol induces interferon gene expression and apoptosis in osteosarcoma cells

2002 • 48 citations

Inhibition of Normal and Experimental Angiotumor Endothelial Cell Proliferation and Cell Cycle Progression by 2-Methoxyestradiol

1998 • 46 citations

The excretion of five different 2-hydroxyoestrogen monomethyl ethers in human pregnancy urine

1976 • 45 citations

2-Methoxyestradiol, an endogenous estrogen metabolite, induces thyroid cell apoptosis

2000 • 39 citations

Action of (E)-2′-Deoxy-2′-(fluoromethylene)cytidine on DNA Metabolism: Incorporation, Excision, and Cellular Response

2002 • 30 citations

Gene deletion, a mechanism of induced mutation by arabinosyl nucleosides

1989 • 29 citations

Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships.

2002 • 29 citations

Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts

2001 • 26 citations

Mitochondrial DNA sequence variation in human leukemic cells

1998 • 26 citations

Apoptotic Cell Death in Chronic Lymphocytic Leukemia

1993 • 23 citations

The ability of bovine mammary tissue to synthesize lipids for 96 h when cocultured with liver and adipose tissue

1992 • 8 citations

Cited By (0)

No citing papers found in database