Cellular response to oxidative stress: Signaling for suicide and survival*

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 • 3,295 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

Reactive oxygen species in cell signaling

2000 • 2,844 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Regulation of the G2/M transition by p53

2001 • 1,524 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death

2000 • 1,028 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

2001 • 991 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

Oxidative stress and nuclear factor-κB activation

2000 • 865 citations

Redox Regulation of NF-kappa B Activation

1997 • 852 citations

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

2000 • 807 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

2001 • 774 citations

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

1998 • 742 citations

Role of NF-κB in p53-mediated programmed cell death

2000 • 730 citations

The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis

2000 • 717 citations

Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1

2001 • 700 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Protein kinase C signaling and oxidative stress

2000 • 691 citations

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1999 • 690 citations

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

1997 • 683 citations

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

2000 • 674 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Requirement for ERK Activation in Cisplatin-induced Apoptosis

2000 • 664 citations

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

1997 • 637 citations

Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

1999 • 597 citations

ATM and ATR: networking cellular responses to DNA damage

2001 • 595 citations

The cellular response to p53: the decision between life and death

1999 • 594 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Activation of the JAK-STAT pathway by reactive oxygen species

1998 • 566 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

Hsp70 Prevents Activation of Stress Kinases

1997 • 516 citations

Roles of Nuclear Factor κB in Neuronal Survival and Plasticity

2000 • 465 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival

2000 • 455 citations

Janus kinases: components of multiple signaling pathways

2000 • 452 citations

Induction of apoptosis by the transcription factor c-Jun

1997 • 421 citations

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway

1997 • 390 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

Age-related Decline in Mitogen-activated Protein Kinase Activity in Epidermal Growth Factor-stimulated Rat Hepatocytes

1996 • 351 citations

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

2001 • 349 citations

Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

2000 • 349 citations

Inhibition of Akt Kinase by Cell-permeable Ceramide and Its Implications for Ceramide-induced Apoptosis

1998 • 344 citations

DNA microarrays identification of primary and secondary target genes regulated by p53

2001 • 332 citations

Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase

2001 • 321 citations

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

1999 • 319 citations

Dopamine Induces Apoptosis through an Oxidation-involved SAPK/JNK Activation Pathway

1998 • 310 citations

Mammalian Small Stress Proteins Protect against Oxidative Stress through Their Ability to Increase Glucose-6-phosphate Dehydrogenase Activity and by Maintaining Optimal Cellular Detoxifying Machinery

1999 • 299 citations

Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1

2001 • 297 citations

The Mammalian UV Response

2000 • 295 citations

Jun NH₂-Terminal Kinase Phosphorylation of p53 on Thr-81 Is Important for p53 Stabilization and Transcriptional Activities in Response to Stress

2001 • 290 citations

Heat Shock Protein 72 Modulates Pathways of Stress-induced Apoptosis

1998 • 289 citations

Akt Down-regulation of p38 Signaling Provides a Novel Mechanism of Vascular Endothelial Growth Factor-mediated Cytoprotection in Endothelial Cells

2001 • 287 citations

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation

1999 • 285 citations

Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death.

1998 • 283 citations

Induction of Apoptosis by SB202190 through Inhibition of p38β Mitogen-activated Protein Kinase

1998 • 281 citations

UV activates growth factor receptors via reactive oxygen intermediates.

1996 • 281 citations

Activation of protein kinase B (Akt/RAC‐protein kinase) by cellular stress and its association with heat shock protein Hsp27

1997 • 270 citations

p38 Mitogen-activated Protein Kinase Mediates Bid Cleavage, Mitochondrial Dysfunction, and Caspase-3 Activation during Apoptosis Induced by Singlet Oxygen but Not by Hydrogen Peroxide

2000 • 270 citations

Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.

2000 • 263 citations

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

1993 • 260 citations

Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB

1999 • 257 citations

Oxidative Stress Triggers STAT3 Tyrosine Phosphorylation and Nuclear Translocation in Human Lymphocytes

1999 • 256 citations

Transcriptional Activation of the Human Glutathione Peroxidase Promoter by p53

1999 • 254 citations

FAK Is the Upstream Signal Protein of the Phosphatidylinositol 3-Kinase-Akt Survival Pathway in Hydrogen Peroxide-induced Apoptosis of a Human Glioblastoma Cell Line

1999 • 252 citations

Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress

2000 • 251 citations

Hydrogen Peroxide Activation of Multiple Mitogen‐Activated Protein Kinases in an Oligodendrocyte Cell Line

1999 • 248 citations

Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs

1999 • 247 citations

Oxidative stress interference with the nuclear factor- κB activation pathways

2000 • 243 citations

Hypoxia Induces the Activation of the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway in PC12 Cells

2001 • 242 citations

Phospholipase C-γ as a Signal-Transducing Element

1999 • 242 citations

Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts

2000 • 239 citations

Protein-Damaging Stresses Activate c-Jun N-Terminal Kinase via Inhibition of Its Dephosphorylation: a Novel Pathway Controlled by HSP72

1999 • 239 citations

Endothelial Apoptosis Induced by Oxidative Stress Through Activation of NF-κB

2001 • 236 citations

Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.

2001 • 231 citations

The Jun Kinase/Stress-activated Protein Kinase Pathway Functions to Regulate DNA Repair and Inhibition of the Pathway Sensitizes Tumor Cells to Cisplatin

1997 • 230 citations

Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor.

1996 • 229 citations

The p53 pathway and apoptosis

1999 • 222 citations

Anti-apoptotic effect of quercetin: Intervention in the JNK- and ERK-mediated apoptotic pathways

2000 • 219 citations

Heat shock proteins – modulators of apoptosis in tumour cells

2000 • 216 citations

Reactive Oxygen Species Regulate Heat-Shock Protein 70 via the JAK/STAT Pathway

2001 • 214 citations

How Protein Kinase C Activation Protects Nerve Cells from Oxidative Stress-Induced Cell Death

2001 • 211 citations

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1998 • 209 citations

The 90-kDa Ribosomal S6 Kinase (pp90rsk) Phosphorylates the N-terminal Regulatory Domain of IκBα and Stimulates Its Degradation in Vitro

1997 • 207 citations

Selective Activation of p38 MAPK Cascade and Mitotic Arrest Caused by Low Level Oxidative Stress

2000 • 204 citations

Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

2000 • 200 citations

c-Jun N-terminal Kinase Activation by Hydrogen Peroxide in Endothelial Cells Involves Src-dependent Epidermal Growth Factor Receptor Transactivation

2001 • 199 citations

Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress

2000 • 199 citations

MEK Kinase Is Involved in Tumor Necrosis Factor α-Induced NF-κB Activation and Degradation of IκB-α

1996 • 197 citations

Oxidative Stress Induces DNA Fragmentation and Caspase Activation Via the c-Jun NH2-terminal Kinase Pathway in H9c2 Cardiac Muscle Cells

1998 • 193 citations

Regulation of Immune Responses by NF-κB/Rel Transcription Factors

1998 • 193 citations

The c-Jun N-terminal kinase pathway and apoptotic signaling (review).

2000 • 189 citations

Regulation of p53 stability and activity in response to genotoxic stress

2000 • 186 citations

Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins

2001 • 178 citations

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha ) promoted by hyperosmotic stress

1998 • 175 citations

Reciprocal down-regulation of p53 and SOD2 gene expression–implication in p53 mediated apoptosis

2001 • 174 citations

Targeting of protein kinase C delta to mitochondria in the oxidative stress response.

2001 • 171 citations

Activation of AP‐1 and Nuclear Factor‐κB Transcription Factors Is Involved in Hydrogen Peroxide‐Induced Apoptotic Cell Death of Olligodendrocytes

1999 • 171 citations

Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation

1996 • 166 citations

Redox signalling and transition metals in the control of the p53 pathway

2000 • 165 citations

Hsp72-Mediated Suppression of c-Jun N-Terminal Kinase Is Implicated in Development of Tolerance to Caspase-Independent Cell Death

2000 • 161 citations

Activation of the Cytoplasmic c-Abl Tyrosine Kinase by Reactive Oxygen Species

2000 • 158 citations

Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?

1997 • 158 citations

Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts

2000 • 156 citations

Tumor Promoter Arsenite Activates Extracellular Signal-Regulated Kinase through a Signaling Pathway Mediated by Epidermal Growth Factor Receptor and Shc

1998 • 155 citations

Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H₂O₂

1997 • 155 citations

Involvement of p85 in p53-dependent apoptotic response to oxidative stress

1998 • 154 citations

Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma.

1998 • 150 citations

ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

1994 • 150 citations

Oxidative Stress-induced Phospholipase C-γ1 Activation Enhances Cell Survival

2001 • 147 citations

Antioxidant‐mediated inhibition of the heat shock response leads to apoptosis

1999 • 143 citations

Reactive Oxygen Species-induced Phosphorylation of p53 on Serine 20 Is Mediated in Part by Polo-like Kinase-3

2001 • 138 citations

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

1999 • 134 citations

Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells.

2000 • 133 citations

Loss in oxidative stress tolerance with aging linked to reduced extracellular signal‐regulated kinase and Akt kinase activities

2001 • 133 citations

Tyrosine phosphorylation‐dependent activation of NF‐κB

2001 • 131 citations

Activation of p38 Mitogen-Activated Protein Kinase and Caspases in UVB-Induced Apoptosis of Human Keratinocyte HaCaT Cells

1999 • 131 citations

Protection from oxidative inactivation of the 20S proteasome byheat-shock protein 90

1998 • 128 citations

p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression

2000 • 126 citations

Activated satellite cells fail to restore myonuclear number in spinal cord transected and exercised rats

1999 • 126 citations

The Ataxia telangiectasia Gene Product Is Required for Oxidative Stress-induced G1 and G2Checkpoint Function in Human Fibroblasts

2001 • 125 citations

Identification of Two NF-κB Sites in Mouse CD95 Ligand (Fas Ligand) Promoter: Functional Analysis in T Cell Hybridoma

1998 • 124 citations

Intrastriatal Dopamine Injection Induces Apoptosis Through Oxidation-Involved Activation of Transcription Factors AP-1 and NF-κB in Rats

1999 • 123 citations

Inhibition of C-Jun N-Terminal Kinase 1, but Not c-Jun N-Terminal Kinase 2, Suppresses Apoptosis Induced by Ischemia/Reoxygenation in Rat Cardiac Myocytes

2001 • 122 citations

Hydrogen Peroxide Activates NFκB and the Interleukin-6 Promoter Through NFκB-Inducing Kinase

2001 • 121 citations

Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts

2000 • 120 citations

Hydrogen Peroxide Is a Novel Inducer of Connective Tissue Growth Factor

2001 • 115 citations

Protective Role for c-Jun in the Cellular Response to DNA Damage

2001 • 114 citations

Oxidant-Mediated Activation of Mitogen- Activated Protein Kinases and Nuclear Transcription Factors in the Cardiovascular System

1998 • 108 citations

Suppression of Stress Kinase JNK Is Involved in HSP72-mediated Protection of Myogenic Cells from Transient Energy Deprivation

2000 • 107 citations

Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53

2000 • 106 citations

The Cell Cycle-Regulatory CDC25A Phosphatase Inhibits Apoptosis Signal-Regulating Kinase 1

2001 • 105 citations

Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells

1999 • 104 citations

NF-κB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment

2000 • 103 citations

Targeting of the c-Abl Tyrosine Kinase to Mitochondria in the Necrotic Cell Death Response to Oxidative Stress

2001 • 101 citations

Role of small heat shock protein HSP25 in radioresistance and glutathione-redox cycle

2000 • 99 citations

Detection of Undegraded Oligonucleotides in Vivo by Fluorescence Resonance Energy Transfer

1996 • 97 citations

Protective roles for ATM in cellular response to oxidative stress

2000 • 97 citations

Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytes

1996 • 97 citations

Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: implications for cellular survival and tumor promotion.

1996 • 96 citations

Requirement for Protein Kinase C in Reactive Oxygen Species–Induced Apoptosis of Vascular Smooth Muscle Cells

1999 • 95 citations

p53 and IGFBP-3: Apoptosis and Cancer Protection

2000 • 95 citations

Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells

1999 • 94 citations

UV Induces Phosphorylation of Protein Kinase B (Akt) at Ser-473 and Thr-308 in Mouse Epidermal Cl 41 Cells through Hydrogen Peroxide

2001 • 94 citations

Activation of MEK Kinase 1 by the c-Abl Protein Tyrosine Kinase in Response to DNA Damage

2000 • 93 citations

Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate

2001 • 91 citations

p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest

2000 • 88 citations

Regulation of Protein Kinase B

1999 • 86 citations

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death.

1998 • 85 citations

Increased expression of heat shock protein-70 protects A549 cells against hyperoxia

1998 • 82 citations

Preconditioning regulation of bcl‐2 and p66^shc by human NOS1 enhances tolerance to oxidative stress

2000 • 81 citations

Oxidative Preconditioning and Apoptosis in L-cells

2001 • 81 citations

Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death

2002 • 79 citations

Neuroprotective Role for the p50 Subunit of NF-κB in an Experimental Model of Huntington's Disease

2000 • 78 citations

Neuropeptide Y inhibits ciliary beat frequency in human ciliated cells via nPKC, independently of PKA

1998 • 75 citations

IGFBp-3 prolongs the p53 response and enhances apoptosis following UV irradiation

2000 • 75 citations

Identification of Hydrogen Peroxide as the Relevant Messenger in the Activation Pathway of Transcription Factor NF-κB

1996 • 75 citations

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFα- and hydrogen peroxide-induced cell death

1998 • 70 citations

Syk Is Required for the Activation of Akt Survival Pathway in B Cells Exposed to Oxidative Stress

2000 • 68 citations

Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by α-lipoic acid

2001 • 67 citations

Activation of human platelets by peroxovanadate is associated with tyrosine phosphorylation of phospholipase Cγ and formation of inositol phosphates

1993 • 65 citations

H2O2 mediates oxidative stress-induced epidermal growth factor receptor phosphorylation

2001 • 63 citations

Cyanide-Induced Apoptosis Involves Oxidative-Stress-Activated NF-κB in Cortical Neurons

2000 • 62 citations

c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation

1999 • 58 citations

Overexpression of HSP25 reduces the level of TNFα-induced oxidative DNA damage biomarker, 8-hydroxy-2′-deoxyguanosine, in L929 cells

1998 • 55 citations

Akt1/PKBα Protects PC12 Cells against the Parkinsonism-Inducing Neurotoxin 1-Methyl-4-phenylpyridinium and Reduces the Levels of Oxygen-Free Radicals

2001 • 55 citations

Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity

1999 • 54 citations

Amino-terminal-derived JNK Fragment Alters Expression and Activity of c-Jun, ATF2, and p53 and Increases H2O2-induced Cell Death

2000 • 54 citations

Selective protection by hsp 70 against cytotoxic drug‐, but not Fas‐induced T‐cell apoptosis

1999 • 54 citations

HSP72 can protect cells from heat-induced apoptosis by accelerating the inactivation of stress kinase JNK

2000 • 53 citations

Induction of heat shock protein 70 protects mesangial cells against oxidative injury

1999 • 53 citations

Lipid constituents in oligodendroglial cells alter susceptibility to H₂O₂‐induced apoptotic cell death via ERK activation

2001 • 51 citations

Activation and tyrosine phosphorylation of p72syk as well as calcium mobilization after hydrogen peroxide stimulation in peripheral blood lymphocytes

1995 • 49 citations

Negative Regulation of Human Heme Oxygenase in Microvessel Endothelial Cells by Dexamethasone

1999 • 48 citations

Constitutive hsp70 Attenuates Hydrogen Peroxide-Induced Membrane Lipid Peroxidation

1999 • 47 citations

Key role of PKC and Ca²⁺in EGF protection of microtubules and intestinal barrier against oxidants

2001 • 45 citations

Phospholipase C-γ inhibition prevents EGF protection of intestinal cytoskeleton and barrier against oxidants

2001 • 45 citations

Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells

2000 • 36 citations

NF-κB mediates the adaptation of human U937 cells to hydrogen peroxide

2001 • 36 citations

The p66shc Protein: A Mediator of the Programmed Death of an Organism?

2000 • 32 citations

Age-Related Changes in Activation of Mitogen-Activated Protein Kinase Cascades by Oxidative Stress

1998 • 31 citations

Heat-shock preconditioning reduces oxidative protein denaturation and ameliorates liver injury by carbon tetrachloride in rats

1999 • 30 citations

Apoptotic response and cell cycle transition in ataxia telangiectasia cells exposed to oxidative stress

2000 • 29 citations

Reactive Oxygen Species as Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation in Keratinocytes

2000 • 25 citations

Overexpression of phospholipase Cβ-1 protects NIH3T3 cells from oxidative stress-induced cell death

2000 • 24 citations

Overexpression of phospholipase C-γ1 suppresses UVC-induced apoptosis through inhibition of c-fos accumulation and c-Jun N-terminal kinase activation in PC12 cells

1999 • 23 citations

The real Dorian Gray mouse

2000 • 21 citations

Age-Related Changes in Activation of Mitogen-Activated Protein Kinase Cascades by Oxidative Stress

1998 • 14 citations