Role of Reactive Oxygen Species and p53 in Chromium(VI)-induced Apoptosis

Mitochondria and Apoptosis

1998 • 8,909 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

1991 • 1,505 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

1999 • 708 citations

Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells

1994 • 637 citations

Signaling to p53

1998 • 636 citations

Reactive oxygen intermediates as mediators of programmed cell death in plants and animals

1999 • 594 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Genotoxicity of chromium compounds. A review

1990 • 451 citations

REDUCTION OF CHROMIUM (VI) AND ITS RELATIONSHIP TO CARCINOGENESIS

1999 • 300 citations

Mitochondrial Modifications during Rat Thymocyte Apoptosis: A Study at the Single Cell Level

1994 • 192 citations

On the hydroxyl radical formation in the reaction between hydrogen peroxide and biologically generated chromium(V) species

1990 • 184 citations

Cobalt-mediated generation of reactive oxygen species and its possible mechanism

1998 • 178 citations

Chromium (V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium (VI)

1989 • 174 citations

The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element

1996 • 171 citations

Reaction of Cr(VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: role of a Cr(IV)-mediated Fenton-like reaction

1994 • 160 citations

Chromium(VI)-induced nuclear factor-кB activation in intact cells via free radical reactions

1995 • 134 citations

Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes

1991 • 111 citations

Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents.

1996 • 86 citations

Hydroxyl Radical Scavenging Activity of Nonsteroidal Anti-Inflammatory Drugs

1997 • 58 citations

Synthesis of Cr(IV)-GSH, Its Identification and Its Free Hydroxyl Radical Generation: A Model Compound for Cr(VI) Carcinogenicity

1997 • 53 citations

Generation of free radicals from lipid hydroperoxides by Ni2+ in the presence of oligopeptides

1992 • 50 citations

p53 Is a Mediator for Radiation-repressed Human TR2 Orphan Receptor Expression in MCF-7 Cells, a New Pathway from Tumor Suppressor to Member of the Steroid Receptor Superfamily

1996 • 44 citations

One-Electron Reduction of Chromium(VI) by α-Lipoic Acid and Related Hydroxyl Radical Generation, dG Hydroxylation and Nuclear Transcription Factor-κB Activation

1997 • 42 citations