Endogenous opiates: 1994

Kainic acid seizures in the rat

1994 • 693 citations

Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals.

1994 • 336 citations

Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.

1994 • 294 citations

The NMDA Receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids

1994 • 279 citations

Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis.

1994 • 275 citations

Naltrexone-induced alterations in human ethanol intoxication

1994 • 267 citations

A Double‐Blind, Placebo‐Controlled Pilot Study to Evaluate the Efficacy and Safety of Oral Nalmefene HCI for Alcohol Dependence

1994 • 254 citations

Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats

1994 • 253 citations

Combined use of cerebral spinal fluid drainage and naloxone reduces the risk of paraplegia in thoracoabdominal aneurysm repair

1994 • 248 citations

Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome

1994 • 214 citations

Comparing the subjective, psychomotor, and physiological effects of intravenous hydromorphone and morphine in healthy volunteers

2000 • 195 citations

Neuromodulatory systems and memory storage: Role of the amygdala

1993 • 192 citations

Inhibition of opiate tolerance by non-competitive N-d-aspartate receptor antagonists

1994 • 191 citations

Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome, and self-administrative behavior.

1994 • 189 citations

Central nervous system-immune system interactions: psychoneuroendocrinology of stress and its immune consequences

1994 • 182 citations

Increased Evening Activation of the Hypothalamic-Pituitary-Adrenal Axis in Depressed Patients

1994 • 168 citations

Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord

1994 • 152 citations

Differences between Alcohol‐Preferring (AA) and Alcohol‐Avoiding (ANA) Rats in the Prodynorphin and Proenkephalin Systems

1994 • 149 citations

Microwave irradiation affects radial‐arm maze performance in the rat

1994 • 148 citations

Endogenous morphine and related opiates, a new class of chemical messengers

1994 • 146 citations

Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters

1994 • 143 citations

MK‐801 prevents the development of behavioral sensitization during repeated morphine administration

1994 • 135 citations

Role of oxytocin in the neuroadaptation to drugs of abuse

1994 • 134 citations

Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat

1994 • 134 citations

Molecular and cellular mechanisms of opiate action: Studies in the rat locus coeruleus

1994 • 133 citations

Do endogenous opioids mediate the relationship between blood pressure and pain sensitivity in normotensives?

1994 • 130 citations

Hyperpolarization by opioids acting on μ‐receptors of a sub‐population of rat periaqueductal gray neurones in vitro

1994 • 125 citations

Dextromethorphan attenuates and reverses analgesic tolerance to morphine

1994 • 121 citations

Responding for Oral Ethanol after Naloxone Treatment by Alcohol‐Preferring AA Rats

1993 • 121 citations

A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer cell activity.

1994 • 120 citations

Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders

1994 • 120 citations

Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury

1994 • 120 citations

Lower serum prolyl endopeptidase enzyme activity in major depression: Further evidence that peptidases play a role in the pathophysiology of depression

1994 • 117 citations

Nitric oxide and opioid tolerance

1994 • 116 citations

δ-Opioid Receptor Gene Expression in Lymphocytes

1994 • 113 citations

Endogenous κ-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release

1994 • 110 citations

Glucose injections into the medial septum reverse the effects of intraseptal morphine infusions on hippocampal acetylcholine output and memory

1995 • 110 citations

mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein

1994 • 106 citations

Central Neuroanatomical Systems Involved in the Regulation of Food Intake in Birds and Mammals

1994 • 105 citations

The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol

1994 • 104 citations

Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro

1994 • 104 citations

Pain perception in depression: relationships to symptomatology and naloxone-sensitive mechanisms.

1994 • 103 citations

A 24-h inpatient detoxification treatment for heroin addicts: a preliminary investigation

1994 • 102 citations

Non-opioid effects of dynorphins: possible role of the NMDA receptor

1994 • 99 citations

Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement

1994 • 97 citations

Comparison of Potency and Duration of Action of Nalmefene and Naloxone

1994 • 94 citations

Chronic Morphine Administration Increases β‐Adrenergic Receptor Kinase (βARK) Levels in the Rat Locus Coeruleus

1994 • 94 citations

Influence of chronic morphine treatment on protein kinase C activity: comparison with butorphanol and implication for opioid tolerance

1994 • 92 citations

Alternate-day dosing during buprenorphine treatment of opioid dependence

1994 • 91 citations

Chronic variable stress or chronic morphine facilitates immobility in a forced swim test: reversal by naloxone

1994 • 90 citations

Opioid actions on rat anterior cingulate cortex neurons in vitro

1994 • 90 citations

Delta-1 opioid agonist acutely increases hypoxic tolerance.

1994 • 89 citations

Involvement of dopamine and excitatory amino acid transmission in novelty-induced motor activity.

1994 • 89 citations

Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes.

1994 • 88 citations

Naloxone-precipitated morphine withdrawal increases pontine glutamate levels in the rat

1994 • 88 citations

The efficacy of naltrexone in preventing reabuse of heroin after detoxification

1994 • 87 citations

Acute Ethanol-Induced Changes in Cerebral Blood Flow

1995 • 86 citations

Evidence for a bidirectional cross-tolerance between morphine and Δ9-tetrahydrocannabinol in mice

1994 • 86 citations

Behavioral effects of the systemically active delta opioid agonist BW373U86 in rhesus monkeys.

1994 • 86 citations

Repeated and chronic morphine administration causes differential long-lasting changes in dopaminergic neurotransmission in rat striatum without changing its δ- and κ-opioid receptor regulation

1994 • 85 citations

Alterations in mRNA levels of D2 receptors and neuropeptides in striatonigral and striatopallidal neurons of rats with neuroleptic‐induced dyskinesias

1994 • 85 citations

Antagonist-precipitated opioid withdrawal in rats: Evidence for dissociations between physical and motivational signs

1994 • 84 citations

A dose-response analysis of the subjective, psychomotor and physiological effects of intravenous morphine in healthy volunteers.

1994 • 84 citations

Tolerance to opioid analgesics: clinical aspects.

1994 • 83 citations

Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence

1994 • 83 citations

Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells

1994 • 82 citations

Cyclic AMP and ethanol interact to control apoptosis and differentiation in hypothalamic beta-endorphin neurons.

1994 • 82 citations

Naltrexone, an opiate antagonist, fails to modify motor symptoms in patients with Parkinson's disease

1994 • 82 citations

Effects of morphine tolerance and abstinence on cellular immune function

1994 • 81 citations

Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus.

1994 • 80 citations

In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats.

1994 • 78 citations

The activity of opioid analgesics in seizure models utilizing N-methyl-dl-aspartic acid, kainic acid, bicuculline and pentylenetetrazole

1994 • 78 citations

Acute ethanol-induced changes in cerebral blood flow

1994 • 74 citations

Rett syndrome: Controlled study of an oral opiate antagonist, naltrexone

1994 • 72 citations

Genetics of alcoholism: Role of the endogenous opioid system

1994 • 71 citations

Diuretic Effects, Pharmacokinetics, and Safety of a New Centrally Acting Kappa‐Opioid Agonist (CI‐977) in Humans

1994 • 71 citations

Benzodiazepine receptor ligands modulate ethanol drinking in alcohol-preferring rats

1994 • 70 citations

Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus

1994 • 70 citations

Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report

1994 • 67 citations

Sensitization and conditioning of feeding following multiple morphine microinjections into the nucleus accumbens

1994 • 66 citations

Opioid physical dependence development: effects of single versus repeated morphine pretreatments and of subjects' opioid exposure history

1994 • 66 citations

Dynorphin A-(1-13) potently improves the impairment of spontaneous alternation performance induced by the mu-selective opioid receptor agonist DAMGO in mice.

1994 • 65 citations

Neurotensin, substance P, delta and mu opioid receptors are decreased in basal ganglia of parkinson's disease patients

1994 • 64 citations

Naloxone's effects on operant responding depend upon level of deprivation

1994 • 63 citations

Preproenkephalin mRNA expression in the developing and adult rat brain

1994 • 62 citations

Delta-1 opioid receptor dependence of acute hypoxic adaptation.

1994 • 60 citations

Pain perception in self-injurious borderline patients: Naloxone effects

1994 • 60 citations

The CCK-B receptor antagonist Cl 988 reverses tolerance to morphine in rats

1994 • 60 citations

Effect of morphine and methadone acute treatment on immunological activity in mice: pharmacokinetic and pharmacodynamic correlates.

1994 • 59 citations

U50, 488 increases ultrasonic vocalizations in 3‐, 10‐, and 18‐day‐old rat pups in isolation and the home cage

1994 • 59 citations

Acidosis stimulates beta-endorphin release during exercise

1994 • 59 citations

Antinociceptive and respiratory effects of nalbuphine in rhesus monkeys.

1994 • 59 citations

Effect of acute stress on the expression of hypothalamic messenger ribonucleic acids encoding the endogenous opioid precursors preproenkephalin A and proopiomelanocortin

1994 • 58 citations

Corticotrophin-releasing hormone and β-endorphin in labour

1994 • 58 citations

Drug Abuse and Dependence

1994 • 58 citations

Aging, Cardiac Proenkephalin mRNA and Enkephalin Peptides in the Fisher 344 Rat

1994 • 57 citations

Difference between plasma N- and C-terminally directed beta-endorphin immunoreactivity in infantile autism

1994 • 57 citations

Comparison of kappa opioids in rhesus monkeys: behavioral effects and receptor binding affinities.

1994 • 55 citations

Clonidine attenuates conditioned aversion produced by naloxone-precipitated opiate withdrawal

1994 • 55 citations

Dynorphin A-induced rat spinal cord injury: evidence for excitatory amino acid involvement in a pharmacological model of ischemic spinal cord injury.

1994 • 54 citations

The inhibitory effect of norharman on morphine withdrawal syndrome in rats: Comparison with ibogaine

1994 • 54 citations

Influence of 5-HT3 receptor antagonists and the indirect 5-HT agonist, dexfenfluramine, on heroin self-administration in rats

1994 • 54 citations

Selective alterations in macronutrient intake of food-deprived or glucoprivic rats by centrally-administered opioid receptor subtype antagonists in rats

1994 • 54 citations

1-aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance

1994 • 54 citations

The role of δ-opioid receptor subtypes in cocaine- and methamphetamine-induced place preferences

1994 • 53 citations

Implantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance

1994 • 53 citations

Chronic morphine affects working memory during treatment and withdrawal in rats

1994 • 51 citations

Evaluation of delayed treatment of focal cerebral ischemia with three selective kappa-opioid agonists in cats.

1994 • 51 citations

A protein kinase inhibitor, H-7, inhibits the development of tolerance to opioid antinociception

1994 • 51 citations

Cotransmitter-mediated locus coeruleus action on motoneurons

1994 • 51 citations

Enhanced activity of the brain β-endorphin system by free-choice ethanol drinking in C57BL/6 but not DBA/2 mice

1994 • 51 citations

Comparative effects of NG-monomethyl-d-arginine and MK-801 on the abstinence syndrome in morphine-dependent mice

1994 • 50 citations

The role of endogenous nitric oxide in the gastroprotective action of morphine

1994 • 50 citations

μ-Opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia

1994 • 50 citations

Striatal changes in preproenkephalin mRNA levels in parkinsonian monkeys

1994 • 49 citations

Physical dependence produced by central morphine infusions: An anatomical mapping study

1994 • 49 citations

The role of multiple opioid receptors in the potentiation of reward by food restriction

1994 • 49 citations

Effects of chronic food restriction on mu and kappa opioid binding in rat forebrain: a quantitative autoradiographic study

1994 • 48 citations

The effects of morphine on memory consolidation in mice involve both D1 and D2 dopamine receptors

1994 • 48 citations

Kappa-selective agonists decrease postsynaptic potentials and calcium components of action potentials in the supraoptic nucleus of rat hypothalamus in vitro

1994 • 47 citations

Neuroleptics block high- but not low-dose heroin place preferences: Further evidence for a two-system model of motivation.

1994 • 47 citations

Alterations of adenosine A1 receptors in morphine dependence

1994 • 47 citations

Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat.

1994 • 46 citations

Blockade of δ-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice

1994 • 46 citations

Comparison of delta opiate receptor agonist induced reward and motor effects between the ventral pallidum and dorsal striatum

1994 • 45 citations

Endothelin plays a role in the maintenance of blood pressure in normotensive guinea pigs

1994 • 45 citations

Frequency-dependent associative long-term potentiation at the hippocampal mossy fiber-CA3 synapse.

1994 • 44 citations

The CCK-B antagonist CI988 enhances the reflex-depressive effect of morphine in axotomized rats

1994 • 44 citations

Postoperative Myoclonus and Rigidity After Anesthesia with Opioids

1994 • 44 citations

The opioid agonist codeine and antagonist naltrexone do not affect voluntary suppression of capsaicin induced cough in healthy subjects

1994 • 43 citations

Effects of an acute immobilization stress upon proopiomelanocortin (POMC) mRNA levels in the mediobasal hypothalamus: a quantitative in situ hybridization study

1994 • 43 citations

Changes in glutamate receptor and proenkephalin gene expression after kindled seizures

1994 • 43 citations

Role of Opioid Peptides in the Regulation of Cytokine Production by Murine CD4+ T Cells

1994 • 43 citations

Naltrexone antagonizes the analgesic and immunosuppressive effects of morphine in mice.

1994 • 42 citations

Effects of chronic food restriction on prodynorphin-derived peptides in rat brain regions

1994 • 42 citations

Dexamethasone‐induced selective inhibition of the central μ opioid receptor: functional in vivo and in vitro evidence in rodents

1994 • 42 citations

Improvement in major depression after low subcutaneous doses of MIF-1

1994 • 41 citations

Central α-adrenergic involvement in morphine-mediated suppression of splenic natural killer activity

1994 • 41 citations

Drug discrimination assessment of agonist-antagonist opioids in humans: a three-choice saline-hydromorphone-butorphanol procedure.

1994 • 41 citations

Diarrhea associated with intestinal inflammation increases the potency of mu and delta opioids on the inhibition of gastrointestinal transit in mice.

1994 • 41 citations

CCK receptor activation may prevent tolerance to morphine in mice

1994 • 41 citations

Kappa Opioids

1994 • 40 citations

Potential adaptations to acute hypoxia: Hct, stress proteins, and set point for temperature regulation

1994 • 40 citations

Serum antibody for somatostatin-14 and prodynorphin 209–240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection

1994 • 40 citations

Effect of dizocilpine (MK-801) on analgesia and tolerance induced by U-50,488H, a κ-opioid receptor agonist, in the mouse

1994 • 40 citations

The role of dopamine D1-receptors in morphine-induced hyperlocomotion in mice

1994 • 40 citations

The role of opioids in newborn pig fluid percussion brain injury

1994 • 40 citations

The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry

1994 • 40 citations

Treatment of high-dose intrathecal morphine overdose

1994 • 39 citations

Aversive properties of theκ opioid agonist U50,488 in the week-old rat pup

1994 • 39 citations

Comparison of motor reflex and vocalization thresholds following systematically administered morphine, fentanyl, and diazepam in the rat: Assessment of sensory and performance variables

1994 • 39 citations

Lesions of the dorsomedial amygdala, but not the nucleus accumbens, reduce the aversiveness of morphine withdrawal in rats.

1994 • 39 citations

Identification of mechanisms and sites of actions of mu and delta opioid receptor activation in the canine intestine.

1994 • 39 citations

Morphine-conditioned analgesia using a taste cue: dissociation of taste aversion and analgesia

1994 • 38 citations

Milk as the proximal mechanism for behavioral change in the newborn

1994 • 38 citations

Effects of intracerebroventricular clonidine on the hypothalamic noradrenaline and plasma corticosterone levels of opiate naive rats and after naloxone-induced withdrawal

1994 • 38 citations

Effect of selective mu1, mu2 and delta2 opioid receptor agonists on gastric functions in the rat

1994 • 38 citations

Effects of midazolam and naloxone in rats tested for sensitivity/reactivity to formalin pain in a familiar, novel or aversively conditioned environment

1994 • 38 citations

Opioid growth factor inhibits DNA synthesis in mouse tongue epithelium in a circadian rhythm-dependent manner

1994 • 38 citations

A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release

1994 • 37 citations

Neuroanatomical and neurochemical mechanisms underlying amygdaloid control of defensive rage behavior in the cat.

1994 • 37 citations

Effects of aging on spinal opioid-induced antinociception

1994 • 37 citations

Pentylenetetrazole-induced seizures stimulate transcription of early and late response genes

1994 • 37 citations

Lack of Hepatotoxicity with Naltrexone Treatment

1994 • 37 citations

Behavioral effects of kappa-opioid-receptor stimulation on neonatal rats.

1994 • 37 citations

Neuroleptics block high- but not low-dose heroin place preferences: Further evidence for a two-system model of motivation.

1994 • 37 citations

Endogenous opioids and hypogonadism in human obesity

1994 • 36 citations

Interplay of somatostatin, opioid, and GABA neurons in the regulation of the peristaltic reflex

1994 • 36 citations

Enkephalin-containing peptides processed from proenkephalin significantly enhance the antibody-forming cell responses to antigens.

1994 • 36 citations

Influence of naloxone upon motor activity induced by psychomotor stimulant drugs

1994 • 36 citations

Effect of a Peripheral and a Central Acting Opioid Antagonist on the Testicular Response to Stress in Rats

1994 • 36 citations

Hypoalgesia in response to sensitization during acute noise stress.

1994 • 36 citations

Effect of ambient temperature on the ability of mu-, kappa- and delta-selective opioid agonists to modulate thermoregulatory mechanisms in the rat.

1994 • 35 citations

Cholecystokinin gene expression in rat amygdaloid neurons: normal distribution and effect of morphine tolerance

1994 • 35 citations

Tegmental pedunculopontine lesions in rats decrease saccharin's rewarding effects but not its memory-improving effect.

1994 • 34 citations

Pavlovian conditioning of morphine-induced alterations of immune status: evidence for opioid receptor involvement

1994 • 34 citations

Tegmental pedunculopontine lesions in rats decrease saccharin's rewarding effects but not its memory-improving effect.

1994 • 34 citations

Behavioral effects of kappa-opioid-receptor stimulation on neonatal rats.

1994 • 34 citations

Neonatal capsaicin treatment in rats results in scratching behavior with skin damage: Potential model of non-painful dysesthesia

1994 • 33 citations

Effects of a chronic inflammatory stress on levels of pro-opiomelanocortin-derived peptides in the rat spleen and thymus

1994 • 33 citations

Does a relationship exist between the quality of stress and the motivation to ingest alcohol?

1994 • 33 citations

Ultrasounds emitted by female rats during agonistic interactions: effects of morphine and naltrexone

1994 • 33 citations

Enkephalinase inhibition facilitates sexual behavior in the male rat but does not produce conditioned place preference

1994 • 33 citations

Chronic morphine induces tolerance and desensitization of μ-opioid receptor but not down-regulation in rabbit

1994 • 32 citations

1-Aminocyclopropanecarboxylic acid protects against dynorphin A-induced spinal injury

1994 • 32 citations

The CCKA receptor antagonist devazepide does not modify opioid self-administration or drug discrimination: comparison with the dopamine antagonist haloperidol

1994 • 32 citations

Opposing activities of brain opioid receptors in the regulation of humoral and cell-mediated immune responses in the rat

1994 • 32 citations

Effect of morphine tolerance and abstinence on the binding of [3H]MK-801 to brain regions and spinal cord of the rat

1994 • 32 citations

Failure to discriminate conspecifics in amygdaloid-lesioned mice

1994 • 31 citations

Differential regional and time course increases in thyrotropin-releasing hormone, neuropeptide Y and enkephalin mRNAs following an amygdala kindled seizure

1994 • 31 citations

Effects of Morphine and Physostigmine on the Ventilatory Response to Carbon Dioxide

1994 • 31 citations

Comparison of cardiovascular effects of mu- and delta-opioid receptor antagonists in dogs with congestive heart failure

1994 • 31 citations

Developmental psychobiological influences on rodent parental behavior

1994 • 31 citations

Quantification of opiate receptors in two patients with mesiobasal temporal lobe epilepsy, before and after selective amygdalo- hippocampectomy, using positron emission tomography

1994 • 31 citations

Opioid antagonist modulation of rat heart development

1994 • 31 citations

Absence of appreciable tolerance and morphine cross-tolerance in rats with adrenal medullary transplants in the spinal cord

1994 • 30 citations

Lesions of the pedunculopontine tegmental nucleus abolish catalepsy and locomotor depression induced by morphine

1994 • 30 citations

Morphine-6-glucoronide: A potent stimulator of locomotor activity in mice

1994 • 30 citations

Ethanol and naloxone differentially upregulate delta opioid receptor gene expression in neuroblastoma hybrid (NG108-15) cells

1994 • 30 citations

Current approaches to the management of constipation.

1994 • 30 citations

Morphine and its psychiatric implications

1994 • 30 citations

The effects of intraventricular injection of β-endorphin on initial estrogen action to induce lordosis behavior

1994 • 30 citations

Beta-Endorphin-Induced Cardiorespiratory Depression is Inhibited by Glycyl-L-Glutamine, a Dipeptide Derived from Beta-Endorphin Processing. Appendix 1

1993 • 30 citations

Sensitization and tolerance to the discriminative stimulus effects of mu-opioid agonists

1994 • 30 citations

Sex dimorphic alterations in postnatal brain catecholarnines after gestational morphine

1995 • 30 citations

The effect of selective opioid antagonists on butorphanol-induced feeding

1994 • 29 citations

A modulatory role of endogenous opioids on prolactin secretion at the end of pregnancy in the rat

1994 • 29 citations

Mesolimbic sites mediate the discriminative stimulus effects of morphine

1994 • 29 citations

Central and systemic kappa-opioid agonists exacerbate neurobehavioral response to brain injury in rats

1994 • 29 citations

Hypoalgesia in response to sensitization during acute noise stress.

1994 • 29 citations

Increase in plasma beta endorphins precedes vasodepressor syncope.

1994 • 29 citations

Effects of in-utero opiate exposure: new paradigms for old questions

1994 • 28 citations

Efficacy of Methylnaltrexone Versus Naloxone for Reversal of Morphine-Induced Depression of Hypoxic Ventilatory Response

1994 • 28 citations

Opiate effects of isolation stress in domestic fowl

1994 • 28 citations

Effects of neuropeptide Y on short-term memory

1994 • 28 citations

Naloxone antagonizes ethanol- but not α-hydroxybutyrate-induced sleep in mice

1994 • 28 citations

Chronic Morphine Treatment Suppresses CTL-Mediated Cytolysis, Granulation, and cAMP Responses to Alloantigen

1994 • 28 citations

Relationship between morphine and etonitazene-induced working memory impairment and analgesia

1994 • 28 citations

Effect of sulpiride or paroxetine on cerebrospinal fluid neuropeptide concentrations in patients with chronic tension-type headache

1994 • 28 citations

Acute and Persistent Suppression of Preproenkephalin mRNA Expression in the Striatum Following Developmental Hypoxic‐Ischemic Injury

1994 • 27 citations

Repeated exposure of rat pups to isolation attenuates isolation‐induced ultrasonic vocalization rates: Reversal with naltrexone

1994 • 27 citations

Effects of μ and δ opioid receptor agonists and antagonists on absence epilepsy in WAG/Rij rats

1994 • 27 citations

Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity

1994 • 27 citations

Delayed Pro‐Opiomelanocortin Activation after Ethanol Intake in Man

1994 • 27 citations

Handling during suckling alters rat behavior but does not reverse the deleterious effects of undernutrition on naltrexone-induced inhibition of exploratory activity.

1994 • 27 citations

Transient down-regulation of neonatal rat brain μ-opioid receptors upon in utero exposure to buprenorphine

1994 • 27 citations

The effects of cocaine-induced seizures on the proenkephalin mRNA level in the mouse hippocampus: A possible involvement of the nitric oxide pathway

1994 • 26 citations

ATP-sensitive K+ channel openers inhibit morphine withdrawal

1994 • 26 citations

Kappa agonist and antagonist properties of mixed action opioids in a pigeon drug discrimination procedure.

1994 • 26 citations

Treatment of alcoholism as a chronic disorder

1994 • 26 citations

The effect of chronic morphine and cocaine administration on the Gs and Go protein messenger RNA levels in the rat hippocampus

1994 • 26 citations

Effect of ω-conotoxin and verapamil on antinociceptive, behavioural and thermoregulatory responses to opioids in the rat

1994 • 26 citations

The role of multiple opioid receptors in the maintenance of stimulation-induced feeding

1994 • 26 citations

Nitric Oxide Synthase Inhibition Blocks Tolerance to the Analgesic Action of k-Opiate Receptor Agonist in the Rat

1994 • 26 citations

Proenkephalin and prodynorphin mRNA level in brain of rats with absence epilepsy

1994 • 26 citations

Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and β-endorphin in the rat

1994 • 25 citations

Enhanced Susceptibility of the Immune System to Stress in Morphine-Tolerant Rats

1994 • 25 citations

Inhibition of morphine tolerance and dependence by diazepam and its relation to the CNS Met-enkephalin levels

1994 • 24 citations

Opioid peptides and testicular activity in the lizard Podarcis s. sicula Raf

1994 • 24 citations

Central and peripheral actions of the novel κ‐opioid receptor agonist, EMD 60400

1994 • 24 citations

Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice.

1994 • 24 citations

Opiate receptors in idiopathic generalised epilepsy measured with [11C]diprenorphine and positron emission tomography

1994 • 24 citations

Opiate and opiate antidiarrhoeal drug action on rat isolated intestine

1994 • 23 citations

The effects of exercise on the oral consumption of morphine and methadone in rats

1994 • 23 citations

Modulation of lipopolysaccharide-induced production of cytokines by methionine-enkephalin

1994 • 23 citations

Chronic pretreatment with naloxone modifies benzodiazepine receptor binding in amygdaloid kindled rats

1994 • 23 citations

Involvement of amino acids, opioids, nitric oxide, and NMDA receptors in learning and memory consolidation in crickets

1994 • 23 citations

Classical conditioning of opioid activity in the fetal rat.

1994 • 23 citations

Cortical and subcortical neuropeptides in Alzheimer's disease

1994 • 22 citations

Serotonin innervation of enkephalin containing neurones in the rat spinal trigeminal nucleus

1994 • 22 citations

Quantitative Properties of Plasma Corticosterone Elevation Induced by Naloxone-Precipitated Withdrawal in Morphine-Dependent Rats

1994 • 22 citations

Comparative effects of intrahippocampal injection of dynorphin A(1–8), dynorphin A(1–13), dynorphin A(1–17), U-50,488H, and dynorphin B on blood pressure and heart rate in spontaneously hypertensive and normotensive Wistar-Kyoto rats

1994 • 22 citations

Differential effects of prolonged restraint stress on proenkephalin gene expression in the brainstem

1994 • 22 citations

Repetitive exposure to the hot-plate test produces stress induced analgesia and alters β-endorphin neuronal transmission within the periaqueductal gray of the rat

1994 • 22 citations

Opiate withdrawal in the infant

1994 • 22 citations

Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids

1994 • 22 citations

Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse

1994 • 22 citations

Activation of μ-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons

1994 • 22 citations

SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine

1994 • 22 citations

Morphine Effects on the Spontaneous Electroencephalogram in Polydrug Abusers: Correlations with Subjective Self-Reports

1994 • 22 citations

Plasma nicotine, plasma β-endorphin and mood states during periods of chronic smoking, abstinence and nicotine replacement

1994 • 22 citations

Expression of opioid peptides in cells and stroma of human breast cancer and adenofibromas

1994 • 21 citations

Effect on morphine-induced catalepsy, lethality, and analgesia by a benzodiazepine receptor agonist midazolam in the rat

1994 • 21 citations

Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia

1994 • 21 citations

Morphine-induced excitation of pyramidal neurons is inhibited by cholecystokinin in the CA1 region of the rat hippocampal slice.

1994 • 21 citations

δ-Opioid receptor agonists inhibit neuromascular transmission in human colon

1994 • 21 citations

Involvement of κ-opioid receptors in opioid dependence/withdrawal: studies using butorphanol

1994 • 21 citations

The Effects of Naloxone on Retinal Ischemia in Rats

1994 • 21 citations

Effects of naloxene on the subjective and psychomotor effects of nitrous oxide in humans

1994 • 20 citations

Microdialysis Reveals Changes in Extracellular Opioid Peptide Levels in the Amygdala Induced by Amygdaloid Kindling Stimulation

1994 • 20 citations

Differential modulation of angiotensin II and hypertonic saline-induced drinking by opioid receptor subtype antagonists in rats

1994 • 20 citations

Naloxone Ameliorates the Learning Deficit Induced by Pentylenetetrazol Kindling in Rats

1994 • 20 citations

Dopamine D1 receptor agonist-induced grooming is blocked by the opioid receptor antagonist naloxone

1994 • 20 citations

Butorphanol increases food-reinforced operant responding in satiated rats

1994 • 20 citations

Naloxone augments sympathetic outflow induced by centrally administered endothelin in conscious rabbits

1994 • 20 citations

Ultrastructural study of the Merkel cell and its expression of met-enkephalin immunoreactivity during fetal and postnatal development in mice.

1994 • 20 citations

<b>REFLEX MODULATION OF GASTRIC AND VESICAL FUNCTION BY ACUPUNCTURE-LIKE STIMULATION IN ANESTHETIZED </b><b>RATS </b>

1994 • 20 citations

Opioids and sexual behavior in the male rabbit: The role of central and peripheral opioid receptors

1994 • 20 citations

Biphasic effects of intraaccumbens μ-opioid peptide agonist DAMGO on locomotor activities

1994 • 20 citations

Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats

1995 • 19 citations

Gender and test dependence of a type of kappa mediated stress induced analgesia in mice

1994 • 19 citations

Naltrexone, dopamine receptor agonists and antagonists, and food intake in rats: 1. Food deprivation

1994 • 18 citations

Contribution of alpha-2 adrenoceptors to kappa opioid agonist-induced water diuresis in the rat.

1994 • 18 citations

Involvement of mesolimbic κ-opioid systems in the discriminative stimulus effects of morphine

1994 • 18 citations

Naloxone-induced anorexia increases neuropeptide Y concentrations in the dorsomedial hypothalamus: Evidence for neuropeptide Y-opioid interactions in the control of food intake

1994 • 18 citations

Opioid antagonist modulation of DNA synthesis in mouse tongue epithelium is circadian dependent

1994 • 18 citations

Kappa opioid effects on fetal behavior: Central administration of U50,488

1994 • 18 citations

Tolerance development to butorphanol: Comparison with morphine

1994 • 18 citations

Serotonin involvement in the discriminative stimulus effects of mu and kappa opioids in rats.

1994 • 18 citations

Proenkephalin gene expression is altered in the brain of spontaneously hypertensive rats during the development of hypertension

1994 • 18 citations

Supraspinal delta opioid receptor mRNA levels are not altered in [D‐Ala²]Deltorphin II tolerant mice

1994 • 18 citations

Participation of opiatergic, GABAergic, and serotonergic systems in the expression of copulatory analgesia in male rats

1994 • 17 citations

Upregulation of the pro-opiomelanocortin gene in motoneurones after nerve section in mice

1994 • 17 citations

Streptozotocin-induced diabetes produces a naltrexone-reversible lowering of self-stimulation threshold

1994 • 17 citations

Classical conditioning of opioid activity in the fetal rat.

1994 • 17 citations

Increase in enkephalin-like immunoreactivity in hippocampi of adults with generalized epilepsy

1994 • 17 citations

Electrophysiological studies on the spinal roles of endogenous opioids in carrageenan inflammation

1994 • 17 citations

Regulation of tyrosine hydroxylase in olfactory bulb cultures: selective inhibition of depolarization-induced increase by endogenous opioids

1994 • 17 citations

Opioid Peptide Modulation of Stress-Induced Plasma Steroid Changes in the Frog Rana esculenta

1994 • 17 citations

Effects induced by BC 264, a selective agonist of CCK-B receptors, on morphine-dependent rats

1994 • 17 citations

Opioid antagonism alters blood glucose homeostasis during exercise in humans

1994 • 17 citations

Cardiovascular Effects of Microinjection of Dynorphin-A(1-8) Into the Hippocampus in Conscious, Spontaneously Hypertensive and Normotensive Wistar-Kyoto Rats

1994 • 17 citations

Dynamic training and circulating neuropeptides in patients with rheumatoid arthritis: a comparative study with healthy subjects.

1994 • 17 citations

Plasticity in spinal opioid control of lower urinary tract function in paraplegic cats

1994 • 17 citations

On the mechanism(s) of morphine-induced hypothermia

1994 • 17 citations

Modulation of hypoalgesia by morphine and number of shock trials: Covariation of a measure of context fear and hypoalgesia

1994 • 17 citations

Interaction between Ethanol and Opioids in a Protozoan Assay

1994 • 16 citations

Antibodies directed against α subunits of Gi, Gx/z, Go and GS transducer proteins reduced the morphine withdrawal syndrome in mice

1994 • 16 citations

Symptoms of premenstrual syndrome as a function of beta-endorphin: Two subtypes

1994 • 16 citations

Acute sensitization to opioid antagonists

1994 • 16 citations

Morphine modulates excitatory amino acid-induced activity in the mouse spinal cord: short-term effects on N-methy-D-aspartate (NMDA) and long-term effects on kainic acid

1994 • 16 citations

Cortisol and Beta-Endorphin Responses to Sleep Deprivation in Major Depression – The Hyperarousal Theories of Sleep Deprivation

1994 • 16 citations

Spinal and Cortical Evoked Potential Studies in the Ketamine-Anesthetized Rabbit

1994 • 16 citations

Lymphokines production by concanavalin A-stimulated mouse splenocytes: modulation by Met-enkephalin and a related peptide

1994 • 16 citations

Effects of kainic acid in the parabrachial region for ongoing respiratory activity and reflexive respiratory suppression

1994 • 16 citations

Lack of adaptive changes in 5-HT sites in perinatally undernourished rats after chronic stress: Opioid influence

1994 • 16 citations

Naloxone stimulates oxygen consumption but not ventilation in hypothyroid hamsters

1994 • 16 citations

Effects of morphine injection into the parabrachial area on saccharin preference: Modulation by lateral hypothalamic neurons

1994 • 15 citations

Regulation of calbindin-D28K gene expression in response to acute and chronic morphine administration

1994 • 15 citations

Endogeneous opioid modulation of hypercapnic-stimulated respiration in the rat

1994 • 15 citations

Prenatal cocaine potentiates the effects of morphine in adult mice

1994 • 15 citations

NMDA receptors, nitric oxide and opioid tolerance

1994 • 15 citations

Nitric oxide synthase inhibition selectively potentiates swim stress antinociception in rats

1994 • 15 citations

Effects of morphine, naloxone, buprenorphine, butorphanol, haloperidol and imipramine on morphine withdrawal signs in cynomolgus monkeys

1994 • 15 citations

Interactions of opioids with caffeine: evaluation by ambulatory activity in mice

1994 • 15 citations

Restoration of ACTH/cortisol and LH responses to naloxone by chronic dopaminergic treatment in Parkinson's disease

1994 • 14 citations

Central administration of the endopeptidase 24.15 inhibitor cFP-AAF-pAB suggests dynorphin as the endogenous ligand underlying behavioral effects of milk in the fetal rat

1994 • 14 citations

Role of endogenous peripheral opioid mechanisms in renal function.

1994 • 14 citations

Cross-tolerance between mu- and kappa-opioid agonists in the guinea pig ileum myenteric plexus.

1994 • 14 citations

Evidence that weaning stimulates the developmental expression of a δ-opioid receptor subtype in the rat

1994 • 14 citations

Buprenorphine and morphine produce equivalent increases in extracellular single unit activity of dopamine neurons in the ventral tegrnental area in vivo

1994 • 14 citations

Opiate withdrawal intensity correlates with the presence of DSLET high-affinity binding

1994 • 14 citations

Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys.

1994 • 14 citations

Evidence for Functional δ-Opiate Receptors in the Rat Intestine

1994 • 14 citations

β-Endorphin content in HIV-infected HuT78 cell line and in peripheral lymphocytes from HIV-positive subjects

1994 • 14 citations

Modulation by catecholamine of hypothalamus-pituitary-adrenocortical (HPA) axis activity in morphine-tolerance and withdrawal

1994 • 14 citations

Endogenous opioid mediation of the inhibitory effect of ethanol on the prolactin response to breast stimulation in normal women

1994 • 14 citations

Differential effects of Tyr-MIF-1, MIF-1, and naloxone on peptide YY-induced hyperphagia

1994 • 14 citations

Effects of naltrexone pellet implantation on morphine tolerance and physical dependence in the rat

1994 • 14 citations

Voluntary oral morphine self-administration in rats: Effect of haloperidol or ondansetron

1994 • 14 citations

Naltrexone, dopamine receptor agonists and antagonists, and food intake in rats: 2. 2-deoxy-d-glucose

1994 • 14 citations

Palatability of a Meal Influences Release of Beta-Endorphin, and of Potential Regulators of Food Intake in Healthy Human Subjects

1994 • 14 citations

Endogenous Opioid System Activity Following Temporary Focal Cerebral Ischemia

1994 • 14 citations

Naltrexone plasma levels, clinical response and effect on weight in autistic children.

1994 • 14 citations

Identification of distinct sites of beta-endorphin that stimulate lymphokine production by murine CD4+ T cells.

1994 • 13 citations

Opiate Receptor Blockade Enhances the Display of Progesterone-Facilitated Lordosis in Juvenile Female Guinea Pigs

1994 • 13 citations

OHM3295: A fentanyl-related 4-Heteroanilido piperidine with analgesic effects but not suppressive effects on splenic NK activity in mice

1994 • 13 citations

Neurogenic inhibition of duodenal and jejunal motility in the anaesthetized rat

1994 • 13 citations

Epidemiology of psychiatric disorders in Edmonton. Drug abuse and dependence.

1994 • 13 citations

Ejaculation induced changes in escape latency in the hot plate test: Pharmacological analysis of anxiolytic versus analgesic effect

1994 • 13 citations

Changes in food-maintained progressive-ratio responding of rats following chronic buprenorphine or methadone administration

1994 • 13 citations

Antinociceptive and hypothermic crosstolerance between continuous and intermittent cold-water swims in rats

1993 • 13 citations

The Results of Exposure to Immobilization, Hemorrhagic Shock, and Cardiac Hypertrophy on -Endorphin in Rat Cardiac Tissue

1994 • 13 citations

Effects of endogenous opioid peptides and their analogs on the activities of hypothalamic arcuate neurons in brain slices from diestrous and ovariectomized rats

1995 • 13 citations

GABA receptor-linked chloride channels and the behavioral effects of naltrexone in rats

1994 • 13 citations

Prenatal administration of methadone in the rat: Acoustic startle amplitude and the rest-activity cycle at 30 days of age

1994 • 12 citations

Atipamezole, an alpha2 antagonist, augments opiate-induced muscle rigidity in the rat

1994 • 12 citations

Beta-endorphin immunoreactivity in spinal fluid and hypoxanthine in vitreous humour related to brain stem gliosis in sudden infant death victims

1994 • 12 citations

Crosstolerance between butorphanol and morphine in rats

1994 • 12 citations

Transient expression of [D-Ala2] deltorphin I-like immunoreactivity in prenatal rat small intestine.

1994 • 12 citations

[Leu]Enkephalin Enhances Active Avoidance Conditioning in Rats and Mice

1994 • 12 citations

Inverse relationship between beta-endorphin immunoreactivity in cerebrospinal fluid and nucleus tractus solitarius in sudden infant death

1994 • 12 citations

Rapid development of tolerance to morphine in the formalin test

1994 • 12 citations

Alpha‐1‐ and 2‐adrenoceptor subsensitivity in siblings of opioid addicts with personality disorders and depression

1994 • 12 citations

Behavioral significance of phasic changes in mesolimbic dopamine-dependent electrochemical signal associated with heroin self-injections

1994 • 12 citations

Nalorphine as a stimulus in drug discrimination learning: Assessment of the role of μ- and κ-receptor subtypes

1994 • 11 citations

Effects of μ-, δ- and κ-agonists on isolated right atria of the rat

1994 • 11 citations

Quaternary naltrexone: its immunomodulatory activity and interaction with brain delta and kappa opioid receptors

1994 • 11 citations

Preventing morphine antinociceptive tolerance by irreversible mu opioid antagonists before the onset of their antagonism

1994 • 11 citations

Repeated Ethanol Differently Affects Opioid Peptide Biosynthesis in the Rat Pituitary

1994 • 11 citations

Acute effects of pentazocine, naloxone and morphine in opioid-dependent volunteers.

1994 • 11 citations

Effect of morphine and naloxone on LH response and sexual behavior of rams (Ovis aries)

1994 • 11 citations

Effect of Some Peptidase Inhibitors on Exogenous and Endogenous Opioid Actions in Guinea-Pig Ileum.

1994 • 11 citations

Opioid drugs and timeout from avoidance

1994 • 11 citations

U50488 reduces the severity of tissue damage in a rabbit model of focal cerebral ischemia

1994 • 11 citations

Postnatal development of [D‐Ala²]deltorphin‐I‐like immunoreactive structures in the rat brain

1994 • 11 citations

Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig heal longitudinal muscle

1994 • 11 citations

Ontogeny and effect of activity on proenkephalin mRNA expression during development of the chick spinal cord

1994 • 11 citations

The novel and highly selective δ-opioid antagonist TIPP(ψ) attenuates morphine tolerance and dependence: Comparison with the effects of naltrindole and TIPP

1994 • 11 citations

Naltrexone administration effects on regional brain monoamines in developing rats

1994 • 10 citations

Activation of the c-fos Gene in Prodynorphin- and Proenkephalin-Expressing Cells of Nucleus Tractus Solitarius after Seizures

1994 • 10 citations

Effects in the rat of intranigral morphine and DAGO on eating and gnawing induced by stress

1994 • 10 citations

Central opioid receptor subtype mediation of isoproterenol-induced drinking in rats

1994 • 10 citations

Naloxone pretreatment blocks acute morphine-induced sensitization to naltrexone

1994 • 10 citations

A deficit in one-trial context fear conditioning is not due to opioid analgesia

1994 • 10 citations

Intracerebral microinjections of dermorphin

1994 • 10 citations

Dynorphin A-(1-13) potently improves galanin-induced impairment of memory processes in mice

1994 • 10 citations

Differing mechanisms for proactive effects of intermittent and single shock on gastric ulceration

1994 • 10 citations

Evidence for serotonergic involvement in saccharin preference in a two-choice test in rehydrating rats

1994 • 10 citations

Effects of Undernutrition During Suckling and Early Post‐Weaning on the Inhibition by Met‐Enkephalin of Striatal Adenylate Cyclase Activity in Adult Rats

1994 • 10 citations

Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system

1994 • 9 citations

The in vivo effects of opioid peptides on the murine immune response

1994 • 9 citations

Alterations in hypothalamic μ-opiate receptor—mediated responses but not methionine enkephalin or proenkephalin messenger RNA levels in rats with acute cholestasis

1994 • 9 citations

Perspectives on opioid tolerance from basic research: behavioural studies after spinal administration in rodents.

1994 • 9 citations

Immunomodulating Effect of Met-Enkephalin on Different Stages of Lymphocyte Proliferation Induced with ConcanavalA in Vitro

1994 • 9 citations

The effects of Naloxone on the post-asphyxic cerebral pathophysiology of newborn lambs

1994 • 9 citations

A Deficit in preprodynorphin mRNA expression in hippocampus of spontaneously hypertensive rats

1994 • 9 citations

Distribution of extrinsic enkephalin-containing nerve fibers in the rat rectum and their origin in the major pelvic ganglion

1994 • 9 citations

Discriminative stimulus and response rate-decreasing effects of kappa opioids: Antagonism by naloxone

1994 • 9 citations

The role of opioid mechanisms in the anorectic effects of stimulants: U50,488H enhances amphetamine inhibition of free feeding in rats

1994 • 9 citations

Involvement of NMDA receptors in naloxone-induced contractions of the isolated guinea pig ileum after preincubation with morphine.

1994 • 9 citations

Regulation of feeding by multiple opioid receptors in cingulate cortex; Follow-up to an in vivo autoradiographic study

1994 • 9 citations

Naloxone does not affect the cardiovascular and sympathetic adjustments to static exercise in humans

1994 • 9 citations

Electrophysiological effects of selective opioid agonists on spontaneous and evoked neuronal activity in the dentate gyrus of the hippocampus in vivo

1994 • 9 citations

The opioid mechanism of interferon-α action

1994 • 9 citations

Effects of morphine withdrawal syndrome on endo-oligopeptidase (EC 3.4.22.19) activity

1994 • 8 citations

Monoamine systems in the discriminative effects of spiradoline, a kappa-opioid agonist

1994 • 8 citations

The therapeutic value of naloxone and manitol in experimental focal cerebral ischemia

1994 • 8 citations

Effects of aging on morphine withdrawal in the rat

1994 • 8 citations

Cardiovascular responses to intra-hippocampal dynorphin A-(1–8) in spontaneously hypertensive rats

1994 • 8 citations

Antagonism of the discriminative stimulus effects of the kappa-opioid agonist spiradoline

1994 • 8 citations

Influence of morphine on the activity of low-threshold visceral mechanoreceptors in cats with acute pericarditis

1994 • 8 citations

Antagonization of fentanyl-induced muscular rigidity by neurotensin at the locus coeruleus of the rat

1994 • 8 citations

Expression of preproenkephalin mRNA in rat superior cervical ganglion during postnatal development

1994 • 8 citations

Increased N-methyl-d-aspartate (NMDA) activity in the mouse spinal cord following morphine does not mediate opioid withdrawal

1994 • 8 citations

Vagal influence on the motility of the feline jejunum.

1994 • 8 citations

Brain and spinal cord kappa opiate receptors and pharmacological responses to U-50,488H in rats of differing ages

1994 • 8 citations

The regulation of hippocampal dynorphin by neural/neuroendocrine pathways: models for effects of aging on an opioid peptide system

1996 • 8 citations

Deficits in shock-induced freezing and naltrexone enhancement of freezing in Fawn Hooded rats

1994 • 8 citations

Opiate Drug Tolerance: An introduction

1994 • 7 citations

Enkephalinase inhibition and hippocampal excitatory effects of exogenous and endogenous opioids

1994 • 7 citations

Assessment of the relative intrinsic efficacy of profadol and meperidine in a pigeon drug discrimination procedure

1994 • 7 citations

Effect of morphine tolerance and abstinence on the binding of [3H]naltrexone to discrete brain regions and spinal cord of the rat

1994 • 7 citations

Met-enkephalin induced escape from dexamethasone immunosuppression

1993 • 7 citations

Lack of catecholamine involvement in the increased luteinizing hormone release due to blockade of κ-opioid receptors in the medial basal hypothalamus during midpregnancy in the rat

1994 • 7 citations

Context-specific sensitization to naloxone-precipitated withdrawal in hamsters: Effect of pimozide

1994 • 7 citations

Receptors Mediating Depressor Responses to Intrahippocampal Injection of L-Glutamate and Dynorphin-A(1-8) in Conscious, Spontaneously Hypertensive and Normotensive Wistar-Kyoto Rats

1994 • 7 citations

A highly potent TIPP-NH2 analog with balanced mixed μ agonist/δ antagonist properties

1994 • 7 citations

Novel peptides and mechanisms of opiate tolerance

1994 • 7 citations

Locomotor and analgesic effects of morphine and acetorphan in rats chronically treated with morphine or thiorphan

1994 • 7 citations

Use of the mouse vas deferens to determine mu, delta, and kappa receptor affinities of opioid antagonists.

1994 • 7 citations

Behavioral effects of systemically administered mu and kappa opioid agonists in the squirrel monkey: Peptides versus alkaloids

1994 • 7 citations

Inhibition by morphine of the cardiovascular and behavioral responses evoked by centrally administered substance P in conscious rats

1994 • 6 citations

Inhibition in the release of immunoreactive β-endorphin from the periaqueductal grey during isometric contractions of cat hind-limb muscles: the effects of clonidine

1994 • 6 citations

Impaired supersensitivity to morphine following chronic naltrexone treatment in senescent rats

1994 • 6 citations

Cerebral dopamine and noradrenaline in mice withdrawn from repeated morphine treatment and development of tolerance to a test dose of morphine

1994 • 6 citations

The form of the conditioned hypoalgesic response resulting from preexposure to a heat Stressor depends on the pain test used

1994 • 6 citations

Respiratory effects and tolerability of Mr 2264 Cl

1994 • 6 citations

Effect of aging on opioid and LHRH receptors in the brain, pituitary, and testis of the male rat

1994 • 6 citations

Interleukin-1 receptor antagonist does not prevent endotoxin-induced inhibition of gastric acid secretion in rats

1994 • 6 citations

The effect of chronic naltrexone pretreatment on associative vs. non-associative morphine tolerance

1994 • 6 citations

Subchronic treatment with fragments of beta-endorphin prevents electroencephalographic seizures and behavioral alterations induced by centrally administered beta-endorphin in the rabbit.

1994 • 6 citations

Pharmacological analysis of the rate-decreasing effects of mu and kappa opioids in pigeons

1994 • 5 citations

Methionine-EnkephalinConcentrations in Discrete Brain Regions, Spinal Cord, Pituitary Gland and Peripheral Tissues of U-50,488H-Tolerant and Abstinent Rats

1994 • 5 citations

The dynorphin and enkephalin systems in alcohol-preferring (AA) and alcohol-avoiding (ANA) rats

1994 • 5 citations

Regional cerebral glucose utilization in withdrawal following systemic and intracerebroventricular sufentanil administration

1994 • 5 citations

Suckling-induced changes in responsivity to the hypoalgesic effect of morphine

1994 • 5 citations

Effects of the δ-opioid agonist, [D-Pen2, D-Pen5]-enkephalin, on fetal lamb EEG

1994 • 5 citations

Failure to reproduce the in vitro cardiac electrophysiological effects of naloxone in humans.

1994 • 5 citations

Met-enkephalin receptors in human gliomas

1994 • 5 citations

Expression of opioid receptors mRNAs in immune cells

1994 • 5 citations

beta-Endorphin-like immunoreactivity in discrete brain regions, spinal cord, pituitary gland and peripheral tissues of U-50,488H-tolerant and -abstinent rats.

1994 • 5 citations

Pharmacological characterization of dynorphin A (1-17)-induced effects on spinal cord-evoked potentials.

1994 • 5 citations

Opiate receptor binding, guinea pig ileum activity, and prolonged analgesia induced by the brain peptide Tyr-W-MIF-1 and two potent analogs

1994 • 5 citations

Effect of Subacute Toluene Administration on the Enkephalinergic Neuromodulatory System in Rats and Protective Action of Ganglioside Treatments

1994 • 5 citations

Multiple effects of long-term morphine treatment on postsynaptic β-adrenergic receptor function in hippocampus: an intracellular analysis

1994 • 5 citations

Proteinergic profiles in cerebrospinal fluid from alcoholic subjects

1994 • 5 citations

Topographical distribution and synaptic localization of δ-opiate receptor immunoreactivity in rat prefrontal cortex

1994 • 5 citations

Effect of dynorphin microinjection in the paraventricular nucleus on the hemodynamic response to hemorrhage in the rat.

1994 • 4 citations

Altered neurochemical and behavioral development of 10-day-old rats perinatally exposed to the κ opioid agonist U-50,488H

1994 • 4 citations

The involvement of opioid delta receptor in restraint-induced antinociception in mice.

1994 • 4 citations

Zur Einf�hrung in das Schmerzproblem

1953 • 4 citations

Effect of Naltrexone Treatment on Insulin Secretion, Insulin Action and Postprandial Thermogenesis in Obesity

1994 • 4 citations

Hemorheological and cardiovascular responses to beta-endorphin and naloxone in healthy subjects and in patients with essential hypertension.

1994 • 4 citations

Different μ opioid receptor subtypes may mediate C-6 substituted oxycodone derivatives induced antinociceptive gastrointestinal and respiratory actions

1994 • 4 citations

Assessing spiradoline-like discriminative effects of DuP 747: Influence of route of administration

1994 • 3 citations

Peripheral Opioid Systems in Cluster Headache

1994 • 3 citations

Hemorheological and cardiovascular responses to beta-endorphin and naloxone in healthy subjects and in patients with essential hypertension

1994 • 3 citations

Release of α-neoendorphin from the anterior pituitary gland of conscious rats

1994 • 3 citations

Upregulation of delta opioid receptor gene expression in NG108-15 cells by naloxone and ethanol

1994 • 3 citations

Delta opioid mediated-increases in hippocampal excitability occur via activation of a delta1-like receptor

1994 • 3 citations

THE INFLUENCE OF CAPTOPRIL AND NALOXONE ON THE VALSALVA MANOEUVRE AND SYSTOLIC TIME INTERVALS IN HEALTHY VOLUNTEERS

1994 • 3 citations

Intrinsic cardiac enkephalins & vagal control

1994 • 3 citations

Effect of morphine treatment on the conversion of dynorphins to enkephalins in rat cortical neurons in primary culture and human neuroblastoma SH-SY5Y cells

1994 • 3 citations

Ontogeny of the circadian rhythm in medial basal hypothalamic ß-endorphin content in female rat

1994 • 3 citations

Opiate agonist and antagonist action on guinea-pig isolated ileum

1994 • 3 citations

Naloxonazine reveals the role of μ1-opioid receptor in the rewarding effects of morphine

1994 • 3 citations

Body temperature and analgesic effects of selective δ1 and δ2 opioid receptor agonists microdialyzed into the POAH and PAG of freely moving rats

1994 • 3 citations

Hepatic uptake and intracellular processsing of opioid pentapeptides

1994 • 3 citations

The μ opioid receptor: Cellular function and tolerance development

1994 • 2 citations

Opioids and stereotypies in coping with chronic stress

1994 • 2 citations

Opioidergic receptors in the arcuate nucleus are not involved in the cardiovascular effects of clonidine

1994 • 2 citations

Discrimination among morphine, saline and naltrexone in rhesus monkeys receiving morphine subchronically

1994 • 2 citations

Effects of chronic ethanol treatment on the POMC mRNA synthesis in the rat pituitary

1994 • 2 citations

Tolerance in hypothalamic β-endorphin neurons following chronic morphine

1994 • 2 citations

Amelioration of narcotic withdrawal features with clonidine and opiate receptors activity

1994 • 2 citations

Tolerance to [D-Ala2,D-Leu5]enkephalin induces an alteration in transcripting the DOR-1

1994 • 2 citations

Changes in circulating plasma met-enkephalin concentrations in feline intestinal ischemia-reperfusion

1994 • 2 citations

Opioid antagonists up-regulate prodynorphin gene expression in rat brain

1994 • 2 citations

Involvement of Met-enkephalin in diazepam induced inhibition of morphine tolerance and dependence

1994 • 2 citations

The prodynorphin system in rat strains with different proneness to opiate dependence

1994 • 2 citations

Lack of involvement of δ-opioid receptor in mediating physical dependence at the hypothalamus-pituitary-adrenocortical (HPA) axis in the rat

1994 • 2 citations

Circadian abnormalities of natural killer (NK) cell activity and immunoreactive ACTH in the peripheral blood of patients with autoimmune rheumatic diseases

1994 • 1 citations

Nitric oxide (NO) synthase inhibitors attenuated naloxone-precipitated withdrawal

1994 • 1 citations

In vivo evidence for the differential development of δ-opioid receptor subtypes

1994 • 1 citations

Effects of U-50 488H, a kappa-agonist, on action potentials of isolated ventricular papillary muscle of guinea pigs.

1994 • 1 citations

Weaning-induced changes in δ-opioid receptor subtypes: Evidence from autoradiography and in situ hybridisation

1994 • 1 citations

Endogenous opioid dependence-functional disturbances in processes of general adaptation — Adaptive effect of substance (SP)

1994 • 1 citations

L-Nitroarginine methyl ester attenuates the development of morphine tolerance and dependence in mice

1994 • 1 citations

Behavioral and neurochemical mechanisms of opioid-antidepressant interactions

1994 • 1 citations

μ Opioid induced respiratory depression antagonized by κ opioid agonist MR-2034 but not by U-50,488H in freely moving rats

1994 • 1 citations

Memory Impairment with Pretreatment but Not with Posttreatment of Quaternary Naloxone

1994 • 1 citations

Deleted Work

1955 • 0 citations