Alterations in mRNA levels of D2 receptors and neuropeptides in striatonigral and striatopallidal neurons of rats with neuroleptic‐induced dyskinesias

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex

1986 • 8,208 citations

The functional anatomy of basal ganglia disorders

1989 • 5,166 citations

Functional architecture of basal ganglia circuits: neural substrates of parallel processing

1990 • 4,029 citations

Primate models of movement disorders of basal ganglia origin

1990 • 3,722 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

D ₁ and D ₂ Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

1990 • 2,873 citations

ON THE METHODS AND THEORY OF RELIABILITY

1976 • 1,334 citations

Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.

1986 • 744 citations

Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.

1987 • 651 citations

Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study

1988 • 649 citations

Multiple D2 dopamine receptors produced by alternative RNA splicing

1989 • 642 citations

Rat brain preproenkephalin mRNA. cDNA cloning, primary structure, and distribution in the central nervous system.

1984 • 540 citations

Distribution of dynorphin and enkephalin peptides in the rat brain

1986 • 519 citations

Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis

1991 • 507 citations

Dopamine receptor gene expression by enkephalin neurons in rat forebrain.

1990 • 469 citations

Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.

1990 • 458 citations

Sequence and expression of the rat prodynorphin gene.

1985 • 382 citations

The EF-hand family of calcium-modulated proteins

1989 • 353 citations

On the origin of substance P and glutamic acid decarboxylase (GAD) in the substantia nigra

1977 • 314 citations

Evidence for a long Leu-enkephalin striopallidal pathway in rat brain

1978 • 300 citations

Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks.

1983 • 286 citations

Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis

1984 • 252 citations

Induction of oral dyskinesias in naive rats by D1 stimulation

1983 • 250 citations

A hypothesis on the pathophysiological mechanisms that underlie levodopa‐ or dopamine agonist‐induced dyskinesia in Parkinson's disease: Implications for future strategies in treatment

1990 • 244 citations

Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia

1990 • 242 citations

Immunohistochemical evidence for a dynorphin immunoreactive striato-nigral pathway

1982 • 224 citations

Neurobiological substrates of tardive dyskinesia: the GABA hypothesis

1984 • 209 citations

Cocaine self-administration differentially alters mRNA expression of striatal peptides

1992 • 201 citations

Extensive co‐occurrence of substance P and dynorphin in striatal projection neurons: An evolutionarily conserved feature of basal ganglia organization

1990 • 187 citations

Vacuous jaw movements and feeding deficits in rats with ventrolateral striatal dopamine depletion: possible relation to parkinsonian symptoms

1991 • 168 citations

Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum

1984 • 167 citations

Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons.

1986 • 161 citations

Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal neuropeptides

1992 • 159 citations

Selective D1 and D2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions

1987 • 156 citations

Similar Time Course Changes in Striatal Levels of Glutamic Acid Decarboxylase and Proenkephalin mRNA Following Dopaminergic Deafferentation in the Rat

1988 • 153 citations

Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy

1990 • 150 citations

Substance P content of substantia nigra after chronic treatment with antischizophrenic drugs

1978 • 149 citations

Dopaminergic regulation of striatal proenkephalin mrna and prodynorphin mrna: Contrasting effects of d1 and d2 antagonists

1988 • 148 citations

Neostriatal enkephalin-immunoreactive neurones project to the globus pallidus

1982 • 140 citations

Region specific regulation of glutamic acid decarboxylase mRNA expression by dopamine neurons in rat brain

1989 • 131 citations

Chronic treatment with haloperidol accelerates the biosynthesis of enkephalins in rat striatum

1979 • 128 citations

Oral dyskinesia in rats following brain lesions and neuroleptic drug administration

1982 • 118 citations

Cholinergic stimulation of the ventrolateral striatum elicits mouth movements in rats: pharmacological and regional specificity

1989 • 116 citations

Lateral striatal cholinergic mechanisms involved in oral motor activities in the rat

1990 • 111 citations

Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway

1990 • 111 citations

Messenger RNAs encoding glutamate-decar☐ylases are differentially affected by nigrostriatal lesions in subpopulations of striatal neurons

1992 • 110 citations

Regulation of methionine-enkephalin precursor messenger RNA in rat striatum by haloperidol and lithium

1983 • 110 citations

Haloperidol increases proenkephalin mRNA levels in the caudate-putamen of the rat: a quantitative study at the cellular level using in situ hybridization

1987 • 109 citations

Reduction of striatal dopaminergic neurotransmission elevates striatal proenkephalin mRNA

1986 • 105 citations

Differential effects of D ₁ and D ₂ agonists in MPTP‐treated primates

1990 • 99 citations

Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level

1990 • 94 citations

Plasticity of [14C]2-deoxy-d-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement

1980 • 89 citations

Involvement of Dopamine D₁ and D₂ Receptors in the Regulation of Proenkephalin mRNA Abundance in the Striatum and Accumbens of the Rat Brain

1992 • 85 citations

Neuroleptic-induced oral dyskinesias: effects of progabide and lack of correlation with regional changes in glutamic acid decarboxylase and choline acetyltransferase activities

1987 • 84 citations

Characterization of a cDNA coding for rat glutamic acid decarboxylase

1990 • 80 citations

Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment

1992 • 78 citations

Effect of Chronic Typical and Atypical Neuroleptic Treatment on Proenkephalin mRNA Levels in the Striatum and Nucleus Accumbens of the Rat

1990 • 72 citations

Selective D2 receptor stimulation induces dyskinesia in parkinsonian monkeys

1992 • 70 citations

Vacuous jaw movements induced by sub-chronic administration of haloperidol: interactions with scopolamine

1993 • 70 citations

Effects of intrastriatal injections of selective dopamine D-1 and D-2 agonists and antagonists on jaw movements of rats

1989 • 70 citations

Effects of dopaminergic stimulation on functional brain metabolism in rats with unilateral substantia nigra lesions

1983 • 69 citations

Regulation of striatal enkephalin turnover in rats receiving antagonists of specific dopamine receptor subtypes.

1987 • 67 citations

Possible interactions between dynorphin and dopaminergic systems in rat basal ganglia and substantia nigra

1985 • 65 citations

Pharmacological Treatments of Tardive Dyskinesia in the 1980s

1988 • 65 citations

Proenkephalin-A gene regulation in the rat striatum: influence of lithium and haloperidol.

1986 • 61 citations

D2 dopaminergic regulation of striatal preproenkephalin mRNA levels is mediated at least in part through cholinergic interneurons

1992 • 59 citations

Regulation of striatonigral prodynorphin peptides by dopaminergic agents

1990 • 54 citations

Chronic haloperidol and clozapine differentially affect dynorphin peptides and substance P in basal ganglia of the rat

1986 • 51 citations

Topography of dopamine behaviours mediated by D1 and D2 receptors revealed by intrastriatal injection of SKF 38393, lisuride and apomorphine in rats with a unilateral 6-hydroxydopamine-induced lesion

1987 • 50 citations

Proenkephalin mRNA levels in rat striatum are increased and decreased, respectively, by selective D2 and D1 dopamine receptor antagonists

1991 • 45 citations

Recent developments in the use of synthetic oligonucleotides for in sity hybridization histochemistry

1988 • 45 citations

Quantitative light microscopic demonstration of increased pallidal and striatal met5-enkephalin-like immunoreactivity in rats following chronic treatment with haloperidol but not with clozapine: Implications for the pathogenesis of neuroleptic-induced movement disorders

1992 • 44 citations

Functional interaction between dopamine D1 and D2 receptors in rat jaw movements

1991 • 34 citations

Effect of haloperidol on glutamete decarboxylase activity in discrete brain areas of the rat

1983 • 32 citations

Comparison between short- and long-term haloperidol administration on somatostatin and substance P concentrations in the rat brain

1988 • 31 citations

Neuroleptic-induced vacuous chewing movements in rodents: incidence and effects of long-term increases in haloperidol dose

1995 • 30 citations

Effects of acute and chronic clozapine and haloperidol administration on 3-metnoxytyramine accumulation in rat prefrontal cortex, nucleus accumbens and striatum

1991 • 29 citations

Clozapine and haloperidol have differential effects on glutamic acid decarboxylase mRNA in the pallidal nuclei of the rat.

1992 • 28 citations

Alterations in cerebral glutamic acid decarboxylase and3H-flunitrazepam binding during continuous treatment of rats for up to 1 year with haloperidol, sulpiride or clozapine

1987 • 28 citations

Tachykinin gene expression in rat limbic nuclei: modulation by dopamine antagonists.

1990 • 28 citations

Involvement of the nucleus accumbens in oral behaviour in the freely moving rat

1993 • 26 citations

Differential dopaminergic regulation of proenkephalin and prodynorphin mRNAs in the basal ganglia of rats

1992 • 25 citations

Regulation of both preproenkephalin mRNA and its derived opioids by haloperidol — a method for measurement of peptides and mRNA in the same tissue extract

1990 • 22 citations

Drug-Induced Movement Disorders

1993 • 20 citations

Increase of striatal Met5-enkephalin-Arg6-Phe7 (YGGFMRF) content elicited by long-term treatment with haloperidol.

1984 • 19 citations

Chronic treatment with chlorpromazine, thioridazine or haloperidol increases striatal enkephalins and their release from rat brain

1991 • 17 citations

Dopaminergic Regulation of Enkephalin Release

1991 • 15 citations

Increases in rat striatal preproenkephalin mRNA levels following chronic treatment with the depot neuroleptic, haloperidol decanoate

1990 • 11 citations