Alterations of adenosine A1 receptors in morphine dependence

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A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

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1991 • 538 citations

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Morphine increases depolarization induced purine release from rat cortical slices

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Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome

1989 • 52 citations

Adaptive changes in the number of Gs- and Gi-proteins underlie adenylyl cyclase sensitization in morphine-treated rat striatal neurons

1993 • 51 citations

The antinociceptive effect of intrathecally administered adenosine analogs in mice correlates with the affinity for the A1-adenosine receptor

1991 • 49 citations

BLOCKADE OF STRIATAL NEURONE RESPONSES TO MORPHINE BY AMINOPHYLLINE: EVIDENCE FOR ADENOSINE MEDIATION OF OPIATE ACTION

1980 • 45 citations

The effect of morphine on purine and acetylcholine release from rat cerebral cortex: Evidence for a purinergic component in morphine's action

1980 • 40 citations

Alterations in the expression of G-proteins and regulation of adenylate cyclase in human neuroblastoma SH-SY5Y cells chronically exposed to low-efficacy μ-opioids

1993 • 40 citations

Changes in adenosine receptor sensitivity in morphine-tolerant and -dependent mice.

1986 • 37 citations

Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: dissociation from gastrointestinal effects in mice.

1992 • 31 citations

In situ hybridization reveals specific increases in Gαs and Gαo mRNA in discrete brain regions of morphine-tolerant rats

1993 • 30 citations

Effect of adenosine analogues on the expression of opiate withdrawal in rats

1992 • 28 citations

Effects of some adenosine analogs on morphine-induced analgesia and tolerance

1990 • 27 citations

Altered amounts of G-protein mRNA and cAMP accumulation after long-term opioid receptor stimulation of neurons in primary culture from the rat cerebral cortex

1992 • 18 citations

Decreased adenosine A2 receptor function in morphine dependent rats

1992 • 18 citations

Purine involvement in morphine antinociception

1984 • 16 citations

Chronic morphine treatment causes down-regulation of spinal adenosine A1 receptors in rats

1992 • 16 citations

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1990 • 13 citations

Influence of adenosine analogs on morphine tolerance and dependence in mice.

1990 • 12 citations

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1991 • 5 citations