MK‐801 prevents the development of behavioral sensitization during repeated morphine administration

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

1991 • 2,025 citations

Reversal of Experimental Parkinsonism by Lesions of the Subthalamic Nucleus

1990 • 1,875 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 1,751 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

Excitatory amino acid receptors and synaptic plasticity

1990 • 872 citations

On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine

1977 • 733 citations

Lesion of the subthalamic nucleus for the alleviation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced parkinsonism in the primate

1991 • 526 citations

Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

Morphine-induced activation of A10 dopamine neurons in the rat

1983 • 485 citations

Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801

1989 • 484 citations

Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1989 • 455 citations

Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats

1982 • 451 citations

The role of reward pathways in the development of drug dependence

1987 • 439 citations

Time‐dose relationships for locomotor activity effects of morphine after acute or repeated treatment

1972 • 439 citations

The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

1989 • 426 citations

Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine

1984 • 424 citations

The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat

1979 • 354 citations

Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine and cocaine.

1988 • 328 citations

Glutamatergic Control of Dopamine Release in the Rat Striatum: Evidence for Presynaptic N‐Methyl‐D‐Aspartate Receptors on Dopaminergic Nerve Terminals

1991 • 324 citations

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

1988 • 302 citations

Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat

1991 • 298 citations

NMDA antagonists potentiate antiparkinsonian actions of <scp>L</scp>‐dopa in monoamine‐depleted rats

1990 • 285 citations

Anatomically Distinct Opiate Receptor Fields Mediate Reward and Physical Dependence

1984 • 265 citations

Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization

1993 • 242 citations

Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamine

1991 • 238 citations

Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 229 citations

NMDA receptors and in vivo dopamine release in the nucleus accumbens and caudatus

1990 • 221 citations

CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.

1988 • 219 citations

Comparison of the behavioral and biochemical effects of the NMDA receptor antagonists, MK-801 and phencyclidine

1989 • 205 citations

Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate

1991 • 201 citations

Individual differences in locomotor activity and sensitization

1991 • 195 citations

A simple model for studying benzodiazepines: Potentiation of hyperactivity induced by cocaine in mice

1982 • 193 citations

Amphetamine behavioral sensitization and the excitatory amino acids

1990 • 188 citations

Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTA

1984 • 181 citations

Experimental approach to individual vulnerability to psychostimulant addiction

1989 • 180 citations

Development of both conditioning and sensitization of the behavioral activating effects of amphetamine is blocked by the non-competitive NMDA receptor antagonist, MK-801

1993 • 180 citations

The behavioural effects of MK-801 in rats: involvement of dopaminergic, serotonergic and noradrenergic systems

1992 • 170 citations

Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats

1989 • 168 citations

DNQX blockade of amphetamine behavioral sensitization

1991 • 163 citations

Non-competitive antagonists are potent activators of ventral tegmental A10 dopamine neurons

1990 • 157 citations

Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats

1992 • 140 citations

MK-801-induced stereotypy and its antagonism by neuroleptic drugs

1990 • 138 citations

Tolerance development to the biphasic effects of morphine on locomotor activity and brain acetylcholine in the rat.

1978 • 113 citations

Behavioral sensitization to MK-801 (dizocilpine)

1993 • 67 citations

The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality

1991 • 65 citations

Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. I. Behavioral characterization.

1985 • 65 citations

Behavioural effects of N-methyl-D-aspartate in the anterodorsal striatum of the rat

1988 • 63 citations

The importance of dopaminergic neurotransmission in the hypermotility response produced by the administration of ?-aspartic acid into the nucleus accumbens

1988 • 60 citations

Genetic differences in the effects of competitive and non-competitive NMDA receptor antagonists on locomotor activity in mice

1991 • 59 citations

Possible abuse potential of the NMDA antagonist MK-801

1989 • 59 citations

Neuroleptic-induced catalepsy as a model of Parkinson's disease II. Effect of glutamate antagonists

1990 • 58 citations

Environment-specific enhancement of the hyperactivity induced by systemic or intra-VTA morphine injections in rats preexposed to amphetamine

1987 • 57 citations

The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior

1992 • 57 citations

Structure and functions of human kininogens

1991 • 43 citations

Competitive and non-competitive N-methyl-D-aspartate antagonists fail to prevent the induction of methamphetamine-induced sensitization

1992 • 40 citations

The competitive NMDA antagonist CGP40.116 enhances L-DOPA response in MPTP-treated marmosets

1992 • 36 citations

Behavioral cross-sensitization between cocaine and enkephalin in the A10 dopamine region

1988 • 31 citations