Inhibition of opiate tolerance by non-competitive N-d-aspartate receptor antagonists

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Excitatory amino acid receptors in the vertebrate central nervous system.

1989 • 1,316 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Excitatory amino acid receptors and synaptic plasticity

1990 • 872 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801

1989 • 484 citations

[³H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

1988 • 453 citations

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor

1989 • 434 citations

Noncompetitive excitatory amino acid receptor antagonists

1990 • 361 citations

The NMDA Receptor

1995 • 356 citations

The NMDA-receptor antagonist CPP abolishes neurogenic ‘wind-up pain’ after intrathecal administration in humans

1992 • 302 citations

Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat

1991 • 298 citations

Excitatory amino acid antagonists

1991 • 240 citations

Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamine

1991 • 238 citations

Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 229 citations

Morphine tolerance as habituation.

1985 • 222 citations

Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.

1993 • 214 citations

Homeostatic theory of drug tolerance: A general model of physiological adaptation.

1991 • 214 citations

A simple model for studying benzodiazepines: Potentiation of hyperactivity induced by cocaine in mice

1982 • 193 citations

Psychoactive drugs; Tolerance and sensitization

1990 • 192 citations

Amphetamine behavioral sensitization and the excitatory amino acids

1990 • 188 citations

NG-Nitro-L-arginine prevents morphine tolerance

1992 • 183 citations

Development of both conditioning and sensitization of the behavioral activating effects of amphetamine is blocked by the non-competitive NMDA receptor antagonist, MK-801

1993 • 180 citations

Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.

1989 • 164 citations

The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat

1992 • 155 citations

Delayed application of MK-801 attenuates development of morphine tolerance in rats

1991 • 138 citations

MK-801 inhibits the development of morphine tolerance at spinal sites

1993 • 98 citations

Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat.

1985 • 96 citations

Opiate tolerance and dependence: recent findings and synthesis.

1991 • 82 citations

MK801 attenuates behavioural adaptation to chronic nicotine administration in rats

1992 • 72 citations

The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality

1991 • 65 citations

Psychotropic Drugs of Abuse

1991 • 62 citations

NMDA antagonist inhibits rapid tolerance to ethanol

1991 • 59 citations

Induction of phencyclidine-like behavior in rats by dextrorphan but not dextromethorphan

1991 • 59 citations

The pharmacological selectivity of three NMDA antagonists

1988 • 53 citations

Tolerance to morphine in the rat: Associative and nonassociative effects.

1988 • 51 citations

Differential inhibition by NMDA antagonists of rapid tolerance to, and cross-tolerance between, ethanol and chlordiazepoxide

1992 • 46 citations

Ketamine retards chronic but not acute tolerance to ethanol

1992 • 46 citations

NMDA receptor inhibition prevents tolerance to cocaine

1992 • 43 citations

Tolerance to morphine in the rat: Associative and nonassociative effects.

1988 • 41 citations

Effect of interdose interval on the development of associative tolerance to morphine in the rat: A dose-response analysis.

1991 • 29 citations

Effects of dose, interdose interval, and drug-signal parameters on morphine analgesic tolerance: Implications for current theories of tolerance.

1989 • 27 citations

Phencyclidine receptors and N-methyl-D-aspartate antagonsim: Electrophysiologic data correlates with known behaviours

1988 • 27 citations

Disposition of [3H] phencyclidine in the rat after single and multiple doses

1980 • 25 citations

Analgesic tolerance produced by morphine pellets is facilitated by analgesic testing

1981 • 22 citations

Associative and non-associative tolerance to morphine: Support for a dual-process habituation model

1988 • 20 citations

Effects of dose, interdose interval, and drug-signal parameters on morphine analgesic tolerance: Implications for current theories of tolerance.

1989 • 19 citations

Environmental modulation of analgesic tolerance induced by morphine pellets

1981 • 18 citations

Effect of interdose interval on the development of associative tolerance to morphine in the rat: A dose-response analysis.

1991 • 18 citations

DOES MK-801 INHIBIT THE DEVELOPMENT OF MORPHINE TOLERANCE IN THE RAT AT SPINAL SITES?

1992 • 6 citations

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