Naltrexone, an opiate antagonist, fails to modify motor symptoms in patients with Parkinson's disease

Parkinsonism

1967 • 11,463 citations

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

1988 • 3,339 citations

Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness

1976 • 811 citations

The Prevention of Acute Gastric Ulcer in the Rat by α-Methyldopa

1967 • 784 citations

Irreversible motor impairment in young addicts ? ephedrone, manganism or both?

2007 • 655 citations

Dopamine receptor gene expression by enkephalin neurons in rat forebrain.

1990 • 469 citations

The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?

1976 • 427 citations

Naltrexone

1988 • 314 citations

Pre- and postsynaptic inhibition by opioids in rat striatum

1992 • 176 citations

Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum

1984 • 167 citations

Neuropeptides in neurological disease

1986 • 162 citations

Assessment of extrapyramidal disorders.

1981 • 137 citations

Peptides and Parkinson's disease

1985 • 112 citations

Opioid receptors and endogenous opioid peptides

1991 • 107 citations

A controlled trial of propoxyphene and naltrexone in patients with tourette's syndrome

1991 • 87 citations

Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain

1983 • 87 citations

Clinical Experience with Naltrexone

1975 • 79 citations

Naltrexone: a clinical perspective.

1984 • 77 citations

Effect of Naloxone on the 'On-Off' Syndrome in Patients Receiving Long-term Levodopa Therapy

1982 • 59 citations

New and Experimental Therapeutic Roles for Naloxone and Related Opioid Antagonists

1984 • 58 citations

A light and electron microscopical study of enkephalin-immunoreactive structures in the rat neostriatum after removal of the nigrostriatal dopaminergic pathway

1991 • 56 citations

Increase of striatal methionin enkephalin content following lesion of the nigrostriatal dopaminergic pathway in adult rats and reversal following the implantation of embryonic dopaminergic neurons: A quantitative immunohistochemical analysis

1991 • 55 citations

Primate model of Parkinson's disease: alterations in multiple opioid systems in the basal ganglia

1984 • 50 citations

Effect of an Opiate Antagonist on Movement Disorders

1978 • 47 citations

Dynorphin levels in parkinsonian patients: Leu5-enkephalin production from either proenkephalin A or prodynorphin in human brain

1985 • 43 citations

Levels of MET-enkephalin, LEU-enkephalin, substance P and cholecystokinin in the brain of the common marmoset following long term 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine treatment

1988 • 39 citations

Naltrexone therapy of apnea in children with elevated cerebrospinal fluid β‐endorphin

1990 • 35 citations

Effect of naltrexone on senile dementia of the Alzheimer type.

1985 • 33 citations

Chronic MPTP treatment reduces substance P and met-enkephalin content in the basal ganglia of the marmoset

1992 • 27 citations

Multiple, single-dose naltrexone administrations fail to effect overall cognitive functioning and plasma cortisol in individuals with probable Alzheimer's disease

1985 • 19 citations

A selective potentiation by naloxone of L-dopa but not atropine suppression of oxotremorine-induced tremor in mice

1985 • 4 citations