Clonidine attenuates conditioned aversion produced by naloxone-precipitated opiate withdrawal

Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

1975 • 1,010 citations

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

1978 • 794 citations

CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS

1978 • 705 citations

Drug reinforcement studied by the use of place conditioning in rat

1982 • 482 citations

Reinforcing properties of morphine and naloxone revealed by conditioned place preferences: a procedural examination

1984 • 307 citations

Conditioned Narcotic Withdrawal in Humans

1977 • 204 citations

Effects of clonidine on morphine withdrawal signs in the rat

1975 • 177 citations

Clonidine in Morphine Withdrawal

1985 • 170 citations

The Clinical Use of Clonidine in Abrupt Withdrawal From Methadone

1981 • 148 citations

Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal

1988 • 132 citations

Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats

1988 • 117 citations

Clonidine for opiate detoxification: outpatient clinical trials

1980 • 111 citations

Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat

1987 • 108 citations

The Heroin Stimulus : Implications for a Theory of Addiction

2012 • 102 citations

Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat.

1985 • 96 citations

Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats

1978 • 74 citations

Naltrexone-induced aversions: Assessment by place conditioning, taste reactivity, and taste avoidance paradigms

1992 • 60 citations

Effects of 5-HT3 receptor antagonists on behavioural measures of naloxone-precipitated opioid withdrawal

1991 • 50 citations

Effects of clonidine and morphine on opioid withdrawal in rhesus monkeys

1986 • 50 citations

Cocaine conditioned place preference is attenuated by chronic buprenorphine treatment

1991 • 45 citations

Social, motor, and autonomic signs of morphine withdrawal: differential sensitivities to catecholaminergic drugs in mice

1988 • 44 citations

Reinforcing properties of clonidine in rhesus monkeys

1982 • 43 citations

The Heroin Stimulus: Implications for a Theory of Addiction

1979 • 41 citations

Clonidine produces a conditioned place preference in rats

1985 • 35 citations

Effects of α2-receptors

1985 • 34 citations

Analgesic and aversive effects of naloxone in BALB/c mice

1992 • 21 citations

Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats

1992 • 10 citations

Interactions of clonidine and naloxone on schedule-controlled behavior in opioid-naive mice

1989 • 10 citations