Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and β-endorphin in the rat

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Studies on the direct spinal action of narcotics in the production of analgesia in the rat.

1977 • 543 citations

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1981 • 503 citations

The Physiology and Pharmacology of Spinal Opiates

1985 • 303 citations

An improved method for chronic catheterization of the rat spinal subarachnoid space

1981 • 167 citations

Chronic Pain in Old and Young Patients: Differences Appear Less Important Than Similarities

1990 • 151 citations

Opioid δ-receptor involvement in supraspinal and spinal antinociception in mice

1987 • 139 citations

Is there such a thing as geriatric pain?

1991 • 108 citations

Analgesics: Neurochemical, behavioral and clinical perspectives

1985 • 106 citations

The direction of opioid agonists towards μ-, δ- and ε-receptors in the vas deferens of the mouse and the rat

1980 • 99 citations

Alterations in Dihydromorphine Binding in Cerebral Hemispheres of Aged Male Rats

1981 • 72 citations

Opiate receptor characteristics in brains from young, mature and aged mice

1988 • 39 citations

Opioid receptors mediating antinociception from β-endorphin and morphine in the periaqueductal gray

1992 • 33 citations

Differences in morphine-induced antinociception and locomotor activity in mature adult and aged mice

1986 • 27 citations

A local serotonergic component involved in the spinal antinociceptive action of morphine

1989 • 25 citations

Spinal β-endorphin analgesia involves an interaction with local monoaminergic systems

1989 • 25 citations

Comparison of the antinociceptive and motor effects of intrathecal opioid agonists in the rat

1991 • 24 citations

A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE

1989 • 20 citations

Litchfield and Wilcoxon I: Confidence Limits of ED50

1987 • 17 citations

Maintenance of beta-endorphin analgesia across age cohorts

1987 • 11 citations