Zinc and copper: Pharmacological probes and endogenous modulators of neuronal excitability

Metals, Toxicity and Oxidative Stress

2005 • 4,696 citations

Neurodegenerative diseases and oxidative stress

2004 • 3,422 citations

Molecular Physiology of P2X Receptors

2002 • 2,845 citations

TRP channels as cellular sensors

2003 • 2,625 citations

Copper, iron and zinc in Alzheimer's disease senile plaques

1998 • 2,035 citations

Copper toxicity, oxidative stress, and antioxidant nutrients

2003 • 1,917 citations

The neurobiology of zinc in health and disease

2005 • 1,756 citations

Store depletion and calcium influx

1997 • 1,422 citations

The metallobiology of Alzheimer's disease

2003 • 1,256 citations

Copper biochemistry and molecular biology

1996 • 1,171 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

Molecular Diversity of K⁺ Channels

1999 • 1,117 citations

The trp ion channel family

2001 • 1,108 citations

Importance of Zinc in the Central Nervous System: The Zinc-Containing Neuron

2000 • 834 citations

The TRP Channels, a Remarkably Functional Family

2002 • 822 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Differential Distribution of Three Members of a Gene Family Encoding Low Voltage-Activated (T-Type) Calcium Channels

1999 • 779 citations

ZINC AND BRAIN INJURY

1998 • 757 citations

Calcium release‐activated calcium current in rat mast cells.

1993 • 729 citations

Potassium leak channels and the KCNK family of two-p-domain subunits

2001 • 697 citations

Regulation of Vertebrate Cellular Mg2+ Homeostasis by TRPM7

2003 • 697 citations

Molecular mechanisms of copper uptake and distribution

2002 • 681 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Resurgence of Sodium Channel Research

2001 • 672 citations

High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors

1997 • 629 citations

TRPM6 Forms the Mg2+ Influx Channel Involved in Intestinal and Renal Mg2+ Absorption

2003 • 610 citations

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

1998 • 540 citations

TRPM7 Provides an Ion Channel Mechanism for Cellular Entry of Trace Metal Ions

2002 • 489 citations

Copper in disorders with neurological symptoms: Alzheimer’s, Menkes, and Wilson diseases

2001 • 478 citations

The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses

2000 • 477 citations

Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry

1997 • 463 citations

The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis

2004 • 458 citations

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

2004 • 453 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model

1996 • 419 citations

Movement of zinc and its functional significance in the brain

2000 • 415 citations

A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties

1992 • 387 citations

A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission

1991 • 378 citations

Synaptically released zinc: physiological functions and pathological effects.

2001 • 362 citations

Dihydropyridine‐sensitive low‐threshold calcium channels in isolated rat hypothalamic neurones.

1989 • 357 citations

P2X4: an ATP-activated ionotropic receptor cloned from rat brain.

1996 • 339 citations

Zinc homeostasis and functions of zinc in the brain.

2001 • 338 citations

Metals and amyloid‐β in Alzheimer's disease

2005 • 334 citations

Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor

1997 • 306 citations

Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

1989 • 298 citations

Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels

1994 • 284 citations

Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels

1992 • 281 citations

Brain, aging and neurodegeneration: Role of zinc ion availability

2005 • 280 citations

NMDA Receptor Activation Mediates Copper Homeostasis in Hippocampal Neurons

2005 • 279 citations

Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.

1989 • 275 citations

Distribution of the P2X2 receptor subunit of the ATP-gated ion channels in the rat central nervous system

1999 • 265 citations

Pharmacology of neuronal background potassium channels

2003 • 256 citations

An Open Rectifier Potassium Channel with Two Pore Domains in Tandem Cloned from Rat Cerebellum

1998 • 248 citations

Central P2X₄and P2X₆Channel Subunits Coassemble into a Novel Heteromeric ATP Receptor

1998 • 246 citations

Zinc-mediated inhibition of GABAA receptors: discrete binding sites underlie subtype specificity

2003 • 246 citations

Zn2+ Ions: Modulators of Excitatory and Inhibitory Synaptic Activity

2004 • 243 citations

The Micromolar Zinc-Binding Domain on the NMDA Receptor Subunit NR2B

2005 • 226 citations

Zinc-Containing Neurons

1994 • 224 citations

Differential Sensitivity of RecombinantN-Methyl-d-Aspartate Receptor Subtypes to Zinc Inhibition

1997 • 210 citations

Divalent cations and the activation kinetics of potassium channels in squid giant axons.

1982 • 205 citations

Selectivity of the Ca binding site in synaptosome Ca channels. Inhibition of Ca influx by multivalent metal cations.

1984 • 195 citations

Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues

1995 • 193 citations

Determination of Na⁺, K⁺, Mg²⁺, Cu²⁺, Zn²⁺, and Mn²⁺ in Rat Brain Regions

1973 • 193 citations

K+-dependent Cerebellar Granule Neuron Apoptosis

2003 • 187 citations

Dihydropyridine‐sensitive and omega‐conotoxin‐sensitive calcium channels in a mammalian neuroblastoma‐glioma cell line.

1992 • 181 citations

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

1995 • 180 citations

Dissociation of the store‐operated calcium current I_CRAC and the Mg‐nucleotide‐regulated metal ion current MagNuM

2002 • 180 citations

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation

1985 • 179 citations

Two-Pore Domain K Channel, TASK-1, in Pulmonary Artery Smooth Muscle Cells

2003 • 176 citations

Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study

1988 • 175 citations

The Copper-transporting ATPases, Menkes and Wilson Disease Proteins, Have Distinct Roles in Adult and Developing Cerebellum

2005 • 173 citations

Evidence for Chelatable Zinc in the Extracellular Space of the Hippocampus, But Little Evidence for Synaptic Release of Zn

2003 • 170 citations

Zn2+ transporters and Zn2+ homeostasis in neurons

2003 • 161 citations

The Molecular Basis of Copper Homeostasis Copper-Related Disorders

2002 • 158 citations

Current understanding of mammalian TRP homologues

2002 • 158 citations

Slowing of sodium channel opening kinetics in squid axon by extracellular zinc.

1982 • 154 citations

Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ

1985 • 154 citations

A modulatory action of divalent cations on transient outward current in cultured rat sensory neurones.

1988 • 153 citations

Modifying the Subunit Composition of TASK Channels Alters the Modulation of a Leak Conductance in Cerebellar Granule Neurons

2005 • 135 citations

Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR

1995 • 127 citations

Differential modulation by zinc and copper of amino acid receptors from rat olfactory bulb neurons

1996 • 125 citations

Brain tissue accumulates 67copper by two ligand-dependent saturable processes. A high affinity, low capacity and a low affinity, high capacity process.

1988 • 123 citations

Calcium antagonist effects on low-threshold (T-type) calcium current in rat isolated hippocampal CA1 pyramidal neurons.

1991 • 122 citations

Zn²⁺ currents are mediated by calcium‐permeable AMPA/Kainate channels in cultured murine hippocampal neurones

2002 • 117 citations

Fluorescent zinc indicators for neurobiology

2002 • 117 citations

Combined Antisense and Pharmacological Approaches Implicate hTASK as an Airway O2 Sensing K+Channel

2001 • 116 citations

Zn2+ potentiates ATP-activated currents in rat sympathetic neurons

1993 • 114 citations

Copper-phenanthroline-induced site-specific oxygen-radical damage to DNA. Detection of loosely bound trace copper in biological fluids

1984 • 114 citations

Labeling of the neurons of origin of zinc-containing pathways by intraperitoneal injections of sodium selenite

1990 • 113 citations

Molecular basis for pharmacological differences between brain and cardiac sodium channels

1992 • 111 citations

Kinetic and mutational analysis of Zn²⁺ modulation of recombinant human inhibitory glycine receptors

2000 • 108 citations

Zn2+ potentiates excitatory action of ATP on mammalian neurons.

1993 • 107 citations

Copper Modulation of NMDA Responses in Mouse and Rat Cultured Hippocampal Neurons

1996 • 105 citations

Zinc and Copper Influence Excitability of Rat Olfactory Bulb Neurons by Multiple Mechanisms

2001 • 103 citations

CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease

2000 • 103 citations

Zn²⁺ current is mediated by voltage‐gated Ca²⁺ channels and enhanced by extracellular acidity in mouse cortical neurones

2000 • 102 citations

Differential Modulation by Copper and Zinc of P2X₂and P2X₄ Receptor Function

1999 • 100 citations

Regional distribution of manganese, iron, copper, and zinc in the rat brain during development

2004 • 95 citations

Endogenous Zinc Inhibits GABA_AReceptors in a Hippocampal Pathway

2004 • 95 citations

Metal ion effects on ion channel gating

2003 • 94 citations

Effects of dietary zinc status on seizure susceptibility and hippocampal zinc content in theEl (epilepsy) mouse

1990 • 93 citations

Zinc and Copper Modulate Differentially the P2X₄ Receptor

2000 • 91 citations

Zn²⁺ modulation of ATP‐responses at recombinant P2X₂ receptors and its dependence on extracellular pH

1998 • 89 citations

The effects of copper ions on glutamate receptors in cultured rat cortical neurons

1996 • 88 citations

Tetradotoxin-sensitive and tetrodotoxin-resistant Na+ channels differ in their sensitivity to Cd2+ and Zn2+

1986 • 88 citations

Zinc‐Induced Seizures: A New Experimental Model of Epilepsy

1983 • 87 citations

Zinc (Zn2+) blocks voltage gated calcium channels in cultured rat dorsal root ganglion cells

1992 • 86 citations

Divalent cation selectivity for external block of voltage-dependent Na+ channels prolonged by batrachotoxin. Zn2+ induces discrete substates in cardiac Na+ channels.

1991 • 82 citations

Distribution of the voltage‐dependent calcium channel α_1G subunit mRNA and protein throughout the mature rat brain

1999 • 80 citations

A heart-like Na+ current in the medial entorhinal cortex

1993 • 78 citations

Selective block of the human 2‐P domain potassium channel, TASK‐3, and the native leak potassium current, IK_SO, by zinc

2004 • 77 citations

Docosahexaenoic Acid Block of Neuronal Voltage-gated K+ Channels: Subunit Selective Antagonism by Zinc

1996 • 75 citations

Hohenheim Consensus Workshop: Copper

2002 • 74 citations

Fast NMDA Receptor–Mediated Synaptic Currents in Neurons From Mice Lacking the ε2 (NR2B) Subunit

2000 • 71 citations

Routes of zinc entry in mouse cortical neurons: role in zinc‐induced neurotoxicity

2000 • 71 citations

Trace Elements and Electrolytes Homeostasis and Their Relation to Antioxidant Enzyme Activity in Brain Hyperexcitability of Epileptic Patients

2004 • 71 citations

Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells.

1992 • 71 citations

Modulatory activity of extracellular H⁺ and Zn²⁺ on ATP‐responses at rP2X₁ and rP2X₃ receptors

1999 • 67 citations

Inhibition of T-Type Calcium Channels Protects Neurons from Delayed Ischemia-Induced Damage

2005 • 65 citations

Inhibitory zinc-enriched terminals in the mouse cerebellum: double-immunohistochemistry for zinc transporter 3 and glutamate decarboxylase

2002 • 64 citations

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

2003 • 63 citations

Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn²⁺

2002 • 61 citations

Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site

1991 • 60 citations

Block of the background K⁺channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor

2002 • 60 citations

GABA receptor-channel complex as a target site of Mercury, copper, zinc, and lanthanides

1994 • 59 citations

Cell type‐specific action of seizure‐induced intracellular zinc accumulation in the rat hippocampus

2005 • 58 citations

Zinc modulation of a transient potassium current and histochemical localization of the metal in neurons of the suprachiasmatic nucleus.

1993 • 56 citations

Zinc reduces dentate granule cell hyperexcitability in epileptic humans

1995 • 55 citations

Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission

1998 • 54 citations

Zinc changes AMPA receptor properties: Results of binding studies and patch clamp recordings

1996 • 53 citations

Cu 2+ , Co 2+ , and Mn 2+ Modify the Gating Kinetics of High-Voltage-Activated Ca 2+ Channels in Rat Palaeocortical Neurons

2003 • 53 citations

What are the roles of the many different types of potassium channel expressed in cerebellar granule cells?

2003 • 52 citations

Guide to Receptors and Channels, 1st Edition

2004 • 50 citations

The Two-Pore-Domain K+ Channels TREK-1 and TASK-3 Are Differentially Modulated by Copper and Zinc

2004 • 49 citations

Dual effect of Zn2+ on multiple types of voltage-dependent Ca2+ currents in rat palaeocortical neurons

2003 • 49 citations

Cellular Transporters for Zinc

2002 • 49 citations

Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell

2004 • 49 citations

Iron inhibits neurotoxicity induced by trace copper and biological reductants

2004 • 46 citations

Cu/Zn superoxide dismutase expression in the postnatal rat brain following an excitotoxic injury

2005 • 45 citations

Properties of ATP-gated channels recorded from rat sympathetic neurons: voltage dependence and regulation by Zn2+ ions

1995 • 45 citations

Modulation of gating of cloned rat and human K+ channels by micromolar Zn2+.

1993 • 45 citations

Zinc movement in the brain under kainate-induced seizures

2003 • 43 citations

Inhibitory Mechanism of Store-operated Ca2+ Channels by Zinc

2004 • 42 citations

Effects of neuroamines and divalent cations on cloned and mutated ATP-gated channels

1997 • 42 citations

Do We Need Zinc to Think?

2003 • 42 citations

[Ca2+]i inhibition of Ca2+ release-activated Ca2+ influx underlies agonist- and thapsigargin-induced [Ca2+]i oscillations in salivary acinar cells.

1994 • 42 citations

Localization of copper to afferent terminals in rat locus ceruleus, in contrast to mitochondrial copper in cerebellum.

1994 • 41 citations

Modulation of the gating of the transient outward potassium current of rat isolated cerebellar granule neurons by lanthanum

1994 • 41 citations

Zn2(+)-induced subconductance events in cardiac Na+ channels prolonged by batrachotoxin. Current-voltage behavior and single-channel kinetics.

1991 • 41 citations

Divalent metals differentially block cloned T-type calcium channels

2003 • 40 citations

Depolarization-Induced 65Zinc Influx into Cultured Cortical Neurons

2002 • 38 citations

Regional distribution of metallothionein, zinc, and copper in the brain of different strains of rats

1999 • 37 citations

Interaction between copper and zinc at GABA_A receptors in acutely isolated cerebellar Purkinje cells of the rat

2000 • 36 citations

Zinc ions are endogenous modulators of neurotransmitter‐stimulated capacitative Ca²⁺ entry in both cultured and in situ mouse astrocytes

2005 • 35 citations

Block of Tetrodotoxin-resistant Na+ Channel Pore by Multivalent Cations

2004 • 35 citations

Purinergic and muscarinic receptor activation activates a common calcium entry pathway in rat neocortical neurons and glial cells

2000 • 30 citations

Inhibition by Zn²⁺ of uridine 5‘ triphosphate‐induced Ca²⁺‐influx but not Ca²⁺‐mobilization in rat phaeochromocytoma cells

1995 • 30 citations

Diverse modulation of olfactory bulb AMPA receptors by zinc

2004 • 29 citations

System-specific O₂ sensitivity of the tandem pore domain K⁺ channel TASK-1

2004 • 28 citations

Distribution of trace elements in the brain of EL (epilepsy) mice

2002 • 28 citations

Permeation by zinc of bovine chromaffin cell calcium channels: relevance to secretion

1994 • 27 citations

Genetically Epilepsy‐Prone Rats are Characterized by Altered Tissue Trace Element Concentrations

1990 • 27 citations

Distribution of neurons expressing α1G subunit mRNA of T-type voltage-dependent calcium channel in adult rat central nervous system

1999 • 25 citations

Generalized seizures alter the cerebral and peripheral metabolism of essential metals in mice

1983 • 25 citations

Zinc current in Helix soma membrane

1982 • 25 citations

Neuromodulator role of zinc and copper during prolonged ATP applications to P2X4 purinoceptors

2003 • 24 citations

Zinc modulation of ionic currents in the horizontal limb of the diagonal band of Broca

1999 • 22 citations

Zn2+ Modulation of Neuronal Transient K+ Current: Fast and Selective Binding to the Deactivated Channels

1999 • 21 citations

Formation of carnosine‐Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X₄ and P2X₇ receptors

2002 • 21 citations

Changes of activation and inactivation gating of the transient potassium current of rat pituitary melanotrophs caused by micromolar Cd²⁺and Zn²⁺

1995 • 21 citations

Effect of sulfhydryl oxidoreduction on permeability of cardiac tetrodotoxin-insensitive sodium channel

1998 • 20 citations

Zinc and Epileptogenesis

2001 • 20 citations

Zinc Activates TREK-2 Potassium Channel Activity

2005 • 19 citations

Modification of potassium channel kinetics by histidine-specific reagents.

1990 • 18 citations

An episodic ataxia type‐1 mutation in the S1 segment sensitises the hKv1.1 potassium channel to extracellular Zn²⁺

2004 • 17 citations

Inhibition by inorganic ions of a sustained calcium signal evoked by activation of mGlu5 receptors in rat cortical neurons and glia

1998 • 17 citations

External Copper Inhibits the Activity of the Large-Conductance Calcium- and Voltage-sensitive Potassium Channel from Skeletal Muscle

2003 • 17 citations

Expression of P2X6, a Purinergic Receptor Subunit, Is Affected by Dietary Zinc Deficiency in Rat Hippocampus

2003 • 16 citations