Block of Tetrodotoxin-resistant Na+ Channel Pore by Multivalent Cations

CRC Handbook of Chemistry and Physics

2014 • 56,288 citations

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

1996 • 1,057 citations

Mechanism of ion permeation through calcium channels

1984 • 850 citations

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

1989 • 815 citations

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

Calcium channel characteristics conferred on the sodium channel by single mutations

1992 • 776 citations

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

1993 • 614 citations

Destruction of Sodium Conductance Inactivation in Squid Axons Perfused with Pronase

1973 • 540 citations

Differential properties of tetrodotoxin-sensitive and tetrodotoxin- resistant sodium channels in rat dorsal root ganglion neurons

1992 • 518 citations

Dynamic Rearrangement of the Outer Mouth of a K+ Channel during Gating

1996 • 451 citations

A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties

1992 • 387 citations

Identification of an Intracellular Peptide Segment Involved in Sodium Channel Inactivation

1988 • 382 citations

Modulation of K+ current by frequency and external [K+]: A tale of two inactivation mechanisms

1995 • 379 citations

An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding

1994 • 289 citations

Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels

1992 • 281 citations

Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons

1998 • 281 citations

Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions

1995 • 277 citations

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

1994 • 274 citations

Voltage Sensors in Domains III and IV, but Not I and II, Are Immobilized by Na+ Channel Fast Inactivation

1999 • 271 citations

On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

1996 • 254 citations

Inorganic Biochemistry, An Introduction

1994 • 232 citations

Blockade of current through single calcium channels by trivalent lanthanide cations. Effect of ionic radius on the rates of ion entry and exit.

1990 • 204 citations

Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia

1998 • 201 citations

Ion Conduction through C-Type Inactivated Shaker Channels

1997 • 185 citations

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating.

1981 • 184 citations

Restoration of inactivation and block of open sodium channels by an inactivation gate peptide

1994 • 165 citations

Complex Blockade of TTX-Resistant Na⁺Currents by Lidocaine and Bupivacaine Reduce Firing Frequency in DRG Neurons

1998 • 165 citations

C-type inactivation of a voltage-gated K+ channel occurs by a cooperative mechanism

1995 • 164 citations

On the Structural Basis for Size-selective Permeation of Organic Cations through the Voltage-gated Sodium Channel

1997 • 150 citations

Identification of an intracellular peptide segment involved in sodium channel inactivation

1988 • 135 citations

The lanthanide ions as structural probes in biological and model systems

2007 • 128 citations

The Orientation and Molecular Movement of a K+ Channel Voltage-Sensing Domain

2003 • 114 citations

Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

1996 • 111 citations

Ion permeation through the L‐type Ca2+ channel in rat phaeochromocytoma cells: two sets of ion binding sites in the pore.

1993 • 107 citations

Depth Asymmetries of the Pore-Lining Segments of the Na+ Channel Revealed by Cysteine Mutagenesis

1996 • 107 citations

Characterization of the high‐affinity Ca2+ binding sites in the L‐type Ca2+ channel pore in rat phaeochromocytoma cells.

1993 • 94 citations

Functional Consequences of a Decreased Potassium Affinity in a Potassium Channel Pore

1999 • 93 citations

Tetrodotoxin‐resistant sodium current of rat nodose neurones: monovalent cation selectivity and divalent cation block.

1987 • 88 citations

Tetradotoxin-sensitive and tetrodotoxin-resistant Na+ channels differ in their sensitivity to Cd2+ and Zn2+

1986 • 88 citations

Calcium ion as a cofactor in Na channel gating.

1991 • 83 citations

Divalent cation selectivity for external block of voltage-dependent Na+ channels prolonged by batrachotoxin. Zn2+ induces discrete substates in cardiac Na+ channels.

1991 • 82 citations

A mutation in the pore of the sodium channel alters gating

1995 • 77 citations

S4 Charges Move Close to Residues in the Pore Domain during Activation in a K Channel

2001 • 76 citations

Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.

1992 • 76 citations

Modification of sodium channel gating by lanthanum. Some effects that cannot be explained by surface charge theory.

1990 • 67 citations

Molecular Movement of the Voltage Sensor in a K Channel

2003 • 66 citations

P-loop Flexibility in Na+ Channel Pores Revealed by Single- and Double-cysteine Replacements

1997 • 63 citations

Na⁺ Channels with Binding Sites of High and Low Affinity for Tetrodotoxin in Different Excitable and Non‐excitable Cells

1982 • 62 citations

Mechanism of Ion Permeation in Skeletal Muscle Chloride Channels

1997 • 61 citations

G-protein modulation of ion permeation through N-type calcium channels

1993 • 61 citations

Molecular motions within the pore of voltage-dependent sodium channels

1997 • 60 citations

The Selectivity Filter of the Voltage-gated Sodium Channel Is Involved in Channel Activation

2001 • 55 citations

Molecular Motions of the Outer Ring of Charge of the Sodium Channel

2003 • 53 citations

Sodium dependent tetrodotoxin-resistant action potentials in a leech neuron

1976 • 51 citations

Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification

1997 • 46 citations

Pore Structure Influences Gating Properties of the T-type Ca2+ Channel α1G

2003 • 43 citations

S4 Charges Move Close to Residues in the Pore Domain during Activation in a K Channel

2001 • 36 citations

Sodium current block caused by group IIb cations in calf Purkinje fibres and in guinea-pig ventricular myocytes

1990 • 34 citations

Pore mutations alter closing and opening kinetics in Shaker K⁺ channels

1998 • 32 citations

Imipramine Inhibition of Transient K+ Current: An External Open Channel Blocker Preventing Fast Inactivation

1998 • 31 citations

The Position of the Fourth Segment of Domain 4 Determines Status of the Inactivation Gate in Na⁺Channels

2003 • 29 citations

Interaction between the Pore and a Fast Gate of the Cardiac Sodium Channel

1999 • 24 citations

Facilitation of Recovery from Inactivation by External Na⁺and Location of the Activation Gate in Neuronal Na⁺Channels

2000 • 23 citations

Effect of Na+ Flow on Cd2+ Block of Tetrodotoxin-resistant Na+ Channels

2002 • 18 citations

Mutation D384N Alters Recovery of the Immobilized Gating Charge in Rat Brain IIA Sodium Channels

2002 • 8 citations