Metal ion effects on ion channel gating

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The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

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The biochemical basis of zinc physiology

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Calcium - a life and death signal

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X-ray structure of a voltage-dependent K+ channel

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Ionic Blockage of Sodium Channels in Nerve

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Rapid induction of Alzheimer A beta amyloid formation by zinc

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Crystal structure and mechanism of a calcium-gated potassium channel

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Neurobiology of Zinc and Zinc-Containing Neurons

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The Electrostatic Properties of Membranes

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Electrostatic Potentials at Membrane-Solution Interfaces

1977 • 822 citations

ZUR THEORIE DER ELEKTROLYTISCHEN DOPPELSCHICHT

1924 • 813 citations

Calcium channel characteristics conferred on the sodium channel by single mutations

1992 • 776 citations

ZINC AND BRAIN INJURY

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A biological function for cadmium in marine diatoms

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Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Biochemistry of the Lanthanides

1990 • 630 citations

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

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Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+

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Charges and Potentials at the Nerve Surface

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Calcium Entry Leads to Inactivation of Calcium Channel in Paramecium

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Molecular model of the action potential sodium channel.

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Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

1991 • 507 citations

A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K ⁺ Channels

1992 • 479 citations

The moving parts of voltage-gated ion channels

1998 • 473 citations

Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy

1999 • 466 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

ELECTROSTATIC INTERACTIONS IN MEMBRANES AND PROTEINS

1986 • 439 citations

Transport Processes and Electrical Phenomena in Ionic Membranes

1953 • 434 citations

The Coordination Chemistry of Yttrium and the Rare Earth Metal Ions

1965 • 407 citations

Voltage-Gated Ion Channels and Electrical Excitability

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Lanthanides as probes for calcium in biological systems

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ION MOVEMENTS DURING NERVE ACTIVITY

1959 • 325 citations

The action of various cations on muscle protoplasm

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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

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Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels

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Eight Potassium Channel Families Revealed by the C. elegans Genome Project

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K+ channels close more slowly in the presence of external K+ and Rb+

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The role of calcium ions in neural processes.

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Interaction of barium ions with potassium channels in squid giant axons

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1982 • 205 citations

Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages

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Environmental impacts and metal exposure of aquatic ecosystems in rivers contaminated by small scale gold mining: the Puyango River basin, southern Ecuador

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Carboxylate-histidine-zinc interactions in protein structure and function

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Two Identical Noninteracting Sites in an Ion Channel Revealed by Proton Transfer

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Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels.

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Slowing of sodium channel opening kinetics in squid axon by extracellular zinc.

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Mercury: A history of quicksilver

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Extracellular Mg2+ regulates activation of rat eag potassium channel

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Gene Triplication deduced from the Tertiary Structure of a Muscle Calcium Binding Protein

1972 • 129 citations

External Calcium Ions Are Required for Potassium Channel Gating in Squid Neurons

1987 • 128 citations

Voltage-Gated K Channels

2003 • 126 citations

Glycosylation of Shaker Potassium Channel Protein in Insect Cell Culture and in Xenopus Oocytes

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Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A

2001 • 118 citations

Zinc and Disease of the Brain

2001 • 117 citations

Lyotropic anions. Na channel gating and Ca electrode response.

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Zn2+ potentiates excitatory action of ATP on mammalian neurons.

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Chance and design in electrophysiology: an informal account of certain experiments on nerve carried out between 1934 and 1952.

1976 • 101 citations

Interactions between divalent cations and the gating machinery of cyclic GMP-activated channels in salamander retinal rods.

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Interactions between a Pore-Blocking Peptide and the Voltage Sensor of the Sodium Channel: An Electrostatic Approach to Channel Geometry

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Calcium ion as a cofactor in Na channel gating.

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Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.

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Answers and Questions from the KvAP Structures

2003 • 76 citations

A Permeant Ion Binding Site Located between Two Gates of the Shaker K+ Channel

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Electrostatic Model of S4 Motion in Voltage-Gated Ion Channels

2003 • 74 citations

The role of calcium ions in the closing of K channels.

1986 • 73 citations

Molecular Movement of the Voltage Sensor in a K Channel

2003 • 66 citations

The screw–helical voltage gating of ion channels

1999 • 61 citations

Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn²⁺

2002 • 61 citations

Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site

1991 • 60 citations

Human Ether-à-go-go–related Gene K+ Channel Gating Probed with Extracellular Ca2+

1999 • 60 citations

Role of the S3-S4 Linker in Shaker Potassium Channel Activation

1997 • 58 citations

Extracellular Mg2+ Modulates Slow Gating Transitions and the Opening of Drosophila Ether-à-Go-Go Potassium Channels

2000 • 57 citations

Zinc modulation of a transient potassium current and histochemical localization of the metal in neurons of the suprachiasmatic nucleus.

1993 • 56 citations

The Intrinsic Electrostatic Potential and the Intermediate Ring of Charge in the Acetylcholine Receptor Channel

2000 • 53 citations

A Novel Extracellular Calcium Sensing Mechanism in Voltage-Gated Potassium Ion Channels

2001 • 51 citations

Role of Individual Surface Charges of Voltage-Gated K Channels

1999 • 50 citations

Localization of the Extracellular End of the Voltage Sensor S4 in a Potassium Channel

2001 • 48 citations

Modulation of gating of cloned rat and human K+ channels by micromolar Zn2+.

1993 • 45 citations

On the mechanism of modulation of transient outward current in cultured rat hippocampal neurons by di- and trivalent cations

1995 • 44 citations

Surface charge and properties of cardiac ATP-sensitive K+ channels.

1994 • 43 citations

Modulation of cardiac Na⁺ current by gadolinium, a blocker of stretch-induced arrhythmias

2001 • 40 citations

Depression of delayed outward K+ current by Co2+ in guinea pig ventricular myocytes

1991 • 38 citations

Membrane Surface Charge

1984 • 38 citations

Surface Charge and Lanthanum Block of Calcium Current in Bullfrog Sympathetic Neurons

1998 • 35 citations

How Does an Ion Channel Sense Voltage?

1997 • 34 citations

Interactions of divalent cations with negatively charged membrane surfaces. I. Discrete charge potential

1979 • 32 citations

Zinc modulates transient outward current gating in hippocampal neurons.

1993 • 30 citations

Proton Inhibition of Sodium Channels: Mechanism of Gating Shifts and Reduced Conductance

1997 • 30 citations

Calcium Ions in Nerve Cell Function

1992 • 30 citations

Blockade of HERG Channels Expressed in Xenopus laevis Oocytes by External Divalent Cations

1999 • 29 citations

Heterogeneity of external surface charges near sodium channels in the nodal membrane of frog nerve

1984 • 28 citations

Metal ion-induced permeability changes in cell membranes: A minireview

1994 • 25 citations

Altered gating of HERG potassium channels by cobalt and lanthanum

2000 • 22 citations

Discrete Charges on Biological Membranes

1992 • 22 citations

pH as a variable in free zinc ion concentration from zinc-containing lozenges

1988 • 22 citations

Zn2+ Modulation of Neuronal Transient K+ Current: Fast and Selective Binding to the Deactivated Channels

1999 • 21 citations

Prolongation of Response of Node of Ranvier by Metal Ions

1959 • 20 citations

Pore accessibility during C‐type inactivation in Shaker K⁺ channels

1998 • 18 citations

Evaluation of membrane surface charge density: a discussion of some models.

1977 • 18 citations

Phosphorylation of K+ channels in the squid giant axon. A mechanistic analysis

1991 • 17 citations

Chemistry of the First-row Transition Metals

1999 • 15 citations

Block of Shaker potassium channels by external calcium ions

2002 • 15 citations

The dual role of calcium: Pore blocker and modulator of gating

1999 • 13 citations

Calcium dependent shifts of Na + channel activation correlated with the state dependence of calcium-binding to the pore

1998 • 11 citations

The Functional Surface Charge Density of a Fast K Channel in the Myelinated Axon of Xenopus laevis

1998 • 10 citations

Surface charges on membranes

1976 • 10 citations

Interaction of monovalent cations with tetrodotoxin and saxitoxin binding at sodium channels of frog myelinated nerve

1990 • 10 citations

Modulation of I A Potassium Current in Adrenal Cortical Cells by a Series of Ten Lanthanide Elements

1998 • 10 citations

The compensation of potential changes produced by trivalent erbium ion in squid giant axon with applied potentials

1978 • 5 citations

Barium modulates the gating of batrachotoxin-treated Na+ channels in high ionic strength solutions

1993 • 5 citations

Deleted Work

1955 • 0 citations