Zn2+ Ions: Modulators of Excitatory and Inhibitory Synaptic Activity

Giant synaptic potentials in immature rat CA3 hippocampal neurones.

1989 • 1,302 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1987 • 852 citations

Importance of Zinc in the Central Nervous System: The Zinc-Containing Neuron

2000 • 834 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy

1998 • 741 citations

ZnT-3, a putative transporter of zinc into synaptic vesicles

1996 • 712 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT 3 gene

1999 • 534 citations

A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain

1987 • 525 citations

The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses

2000 • 477 citations

Constructing inhibitory synapses

2001 • 467 citations

Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry

1997 • 463 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model

1996 • 419 citations

Electron microscopical localization of the zinc in hippocampal mossy fibre synapses by a modified sulfide silver procedure

1967 • 393 citations

A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission

1991 • 378 citations

Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+

1990 • 370 citations

A novel gene involved in zinc transport is deficient in the lethal milk mouse

1997 • 359 citations

Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey

1997 • 352 citations

The Human ZIP1 Transporter Mediates Zinc Uptake in Human K562 Erythroleukemia Cells

2001 • 293 citations

Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels

1994 • 284 citations

AMPA receptor activation potentiates zinc neurotoxicity

1993 • 280 citations

Induction of Mossy Fiber→CA3 Long-Term Potentiation Requires Translocation of Synaptically Released Zn²⁺

2001 • 276 citations

Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.

1989 • 275 citations

Rapid Translocation of Zn²⁺From Presynaptic Terminals Into Postsynaptic Hippocampal Neurons After Physiological Stimulation

2001 • 260 citations

Differential Epilepsy-Associated Alterations in Postsynaptic GABA_A Receptor Function in Dentate Granule and CA1 Neurons

1997 • 250 citations

Ca2+–Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration

2000 • 246 citations

Mossy fiber Zn2+ spillover modulates heterosynapticN-methyl-<scp>d</scp>-aspartate receptor activity in hippocampal CA3 circuits

2002 • 235 citations

Mammalian Zinc Transporters ,

1998 • 226 citations

GABA_A receptors are differentially sensitive to zinc: dependence on subunit composition

1991 • 223 citations

Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors

1994 • 223 citations

Molecular Organization of a Zinc Binding N-Terminal Modulatory Domain in a NMDA Receptor Subunit

2000 • 215 citations

Localization and Release of Glutamic Acid in Relation to the Hippocampal Mossy Fibre Pathway

1973 • 215 citations

Autometallography

1984 • 188 citations

Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition

1998 • 182 citations

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

1995 • 180 citations

Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study

1988 • 175 citations

Slow Kinetics of Miniature IPSCs during Early Postnatal Development in Granule Cells of the Dentate Gyrus

1997 • 172 citations

The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS

1985 • 171 citations

Evidence for Chelatable Zinc in the Extracellular Space of the Hippocampus, But Little Evidence for Synaptic Release of Zn

2003 • 170 citations

Imaging free zinc in synaptic terminals in live hippocampal slices

1997 • 167 citations

Zinc has opposite effects on NMDA and Non-NMDA receptors expressed in xenopus oocytes

1990 • 165 citations

Neurons of origin of zinc-containing pathways and the distribution of zinc-containing boutons in the hippocampal region of the rat

1992 • 163 citations

Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ

1985 • 154 citations

Intracellular free zinc and zinc buffering in human red blood cells

1991 • 151 citations

The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus.

1989 • 151 citations

ZINC IN MATURING RAT BRAIN: HIPPOCAMPAL CONCENTRATION AND LOCALIZATION¹

1972 • 150 citations

Modulation of excitatory synaptic transmission by glycine and zinc in cultures of mouse hippocampal neurons

1988 • 146 citations

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

1994 • 145 citations

Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse

2001 • 138 citations

Enrichment of glutamate in zinc-containing terminals of the cat visual cortex

1992 • 137 citations

Endogenous Zn2+ is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses

2000 • 137 citations

Chronic Zinc Deficiency Alters Neuronal Function of Hippocampal Mossy Fibers

1979 • 134 citations

A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.

1992 • 132 citations

Timm's sulfide silver reaction for zinc during experimental anterograde degeneration of hippocampal mossy fibers

1971 • 125 citations

Zn²⁺ currents are mediated by calcium‐permeable AMPA/Kainate channels in cultured murine hippocampal neurones

2002 • 117 citations

Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity

2001 • 116 citations

Differential effect of zinc on the vertebrate GABA_A‐receptor complex

1990 • 112 citations

Kinetic and mutational analysis of Zn²⁺ modulation of recombinant human inhibitory glycine receptors

2000 • 108 citations

Distribution of histochemically reactive zinc in the forebrain of the rat

1992 • 106 citations

Distribution of the zinc transporter ZnT‐1 in comparison with chelatable zinc in the mouse brain

2002 • 98 citations

Kinetic and Pharmacological Properties of GABA_AReceptors in Single Thalamic Neurons and GABA_A Subunit Expression

2001 • 96 citations

Endogenous Zinc Inhibits GABA_AReceptors in a Hippocampal Pathway

2004 • 95 citations

Zinc Transport in the Brain: Routes of Zinc Influx and Efflux in Neurons

2000 • 94 citations

Modulation of long-term potentiation in rat hippocampal pyramidal neurons by zinc

1994 • 89 citations

The autometallographic zinc-sulphide method. A new approach involvingin vivo creation of nanometer-sized zinc sulphide crystal lattices in zinc-enriched synaptic and secretory vesicles

1996 • 86 citations

Synaptically-released zinc inhibits N-methyl-d-aspartate receptor activation at recurrent mossy fiber synapses

2001 • 78 citations

Zinc-enriched GABAergic terminals in mouse spinal cord

2001 • 73 citations

A novel effect of zinc on the lobster muscle GABA receptor

1982 • 72 citations

Rapid, Experience-Dependent Changes in Levels of Synaptic Zinc in Primary Somatosensory Cortex of the Adult Mouse

2002 • 67 citations

Inhibitory zinc-enriched terminals in the mouse cerebellum: double-immunohistochemistry for zinc transporter 3 and glutamate decarboxylase

2002 • 64 citations

Zinc Uptake into Synaptosomes

1988 • 64 citations

Zinc co‐localizes with GABA and glycine in synapses in the lamprey spinal cord

2001 • 62 citations

Src Potentiation of NMDA Receptors in Hippocampal and Spinal Neurons Is Not Mediated by Reducing Zinc Inhibition

1999 • 61 citations

Pre- and postsynaptic effects of zinc on in vitro prepyriform neurones

1983 • 61 citations

Zinc Inhibits Miniature GABAergic Currents by Allosteric Modulation of GABA_AReceptor Gating

2000 • 60 citations

Deficiencies of Hippocampal Zn and ZnT3 Accelerate Brain Aging of Rat

2000 • 58 citations

Inhibitory zinc-enriched terminals in mouse spinal cord

2001 • 57 citations

Distribution of terminal fields stained for zinc in the neocortex of the rat

1996 • 55 citations

Amygdaloid efferents through the stria terminalis in the rat give origin to zinc‐containing boutons

1989 • 54 citations

Potentiation of inhibitory glycinergic neurotransmission by Zn²⁺: a synergistic interplay between presynaptic P2X₂ and postsynaptic glycine receptors

2002 • 52 citations

Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice

2003 • 51 citations

High-Affinity Zinc Potentiation of Inhibitory Postsynaptic Glycinergic Currents in the Zebrafish Hindbrain

2001 • 51 citations

pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons

2002 • 50 citations

Modulation of GABA‐mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitro.

1994 • 49 citations

Persistent function of mossy fibre synapses after metal chelation with DEDTC (Antabuse)

1975 • 48 citations

Lack of Effect of Mossy Fiber-Released Zinc on Granule Cell GABA_AReceptors in the Pilocarpine Model of Epilepsy

2001 • 47 citations

Zinc and Zolpidem Modulate mIPSCs in Rat Neocortical Pyramidal Neurons

1998 • 46 citations

Properties of GABA‐mediated synaptic potentials induced by zinc in adult rat hippocampal pyramidal neurones.

1993 • 46 citations

Zinc-containing fiber systems in the cochlear nuclei of the rat and mouse

1988 • 44 citations

Augmentation by zinc of NMDA receptor‐mediated synaptic responses in CA1 of rat hippocampal slices: Mediation by Src family tyrosine kinases

2002 • 44 citations

Release of synaptic zinc is substantially depressed by conventional brain slice preparations

2000 • 35 citations

Evidence for a zinc/proton antiporter in rat brain

2000 • 33 citations

Imaging synaptic zinc release in living nervous tissue

2001 • 31 citations

Experience-dependent regulation of synaptic zinc is impaired in the cortex of aged mice

2003 • 29 citations

Thalamic distribution of zinc-rich terminal fields and neurons of origin in the rat

2001 • 26 citations

Zinc and Flunitrazepam Modulation of GABA-Mediated Currents in Rat Suprachiasmatic Neurons

1999 • 23 citations

Zinc enhances GABAergic transmission in rat neocortical neurons

1993 • 22 citations

Induction of giant depolarizing potentials by zinc in area CA1 of the rat hippocampus does not result from block of GABAB receptors

1992 • 21 citations

PSD‐95 eliminates Src‐induced potentiation of NR1/NR2A‐subtype NMDA receptor channels and reduces high‐affinity zinc inhibition

2002 • 19 citations

Tonic GABA secretion of cultured rat hippocampal neurons rapidly transformed by Zn2+ into quantal release

1993 • 17 citations

Giant GABA_B‐mediated Synaptic Potentials Induced by Zinc in the Rat Hippocampus: Paradoxical Effects of Zinc on the GABA_B Receptor

1993 • 15 citations

A voltage-clamp study of the effects of Joro spider toxin and zinc on excitatory synaptic transmission in CA1 pyramidal cells of the guinea pig hippocampal slice

1991 • 15 citations

Differential effects of zinc on hyperpolarizing and depolarizing GABAA synaptic potentials in hippocampal slice cultures

1995 • 6 citations