Current understanding of mammalian TRP homologues

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

The versatility and universality of calcium signalling

2000 • 5,407 citations

Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor

2000 • 3,436 citations

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

2002 • 2,513 citations

A TRP Channel that Senses Cold Stimuli and Menthol

2002 • 2,182 citations

A capsaicin-receptor homologue with a high threshold for noxious heat

1999 • 1,547 citations

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

1999 • 1,456 citations

Store depletion and calcium influx

1997 • 1,422 citations

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

2000 • 1,348 citations

The trp ion channel family

2001 • 1,108 citations

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

2000 • 982 citations

LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

2001 • 900 citations

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

2001 • 877 citations

Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers

2002 • 871 citations

Ion Channels and Their Functional Role in Vascular Endothelium

2001 • 850 citations

Induction of vanilloid receptor channel activity by protein kinase C

2000 • 814 citations

TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain

2001 • 737 citations

TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities

2001 • 714 citations

trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry

1996 • 688 citations

TRPC1, a human homolog of a Drosophila store-operated channel.

1995 • 623 citations

Functional interaction between InsP3 receptors and store-operated Htrp3 channels

1998 • 620 citations

Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption

1999 • 610 citations

Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.

2001 • 597 citations

The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular α ₁ -Adrenoceptor–Activated Ca ²⁺ -Permeable Cation Channel

2001 • 596 citations

Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives

2002 • 595 citations

Molecular Identification of the Apical Ca2+Channel in 1,25-Dihydroxyvitamin D3-responsive Epithelia

1999 • 587 citations

Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects

2001 • 579 citations

Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice

2001 • 567 citations

Visual transduction in Drosophila

2001 • 510 citations

From worm to man: three subfamilies of TRP channels

2000 • 490 citations

The diversity in the vanilloid (TRPV) receptor family of ion channels

2002 • 485 citations

Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

1999 • 473 citations

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1999 • 469 citations

Molecular and Functional Characterization of a Novel Mouse Transient Receptor Potential Protein Homologue TRP7

1999 • 451 citations

TRP2: A candidate transduction channel for mammalian pheromone sensory signaling

1999 • 440 citations

Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5

2000 • 422 citations

Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL

1999 • 400 citations

Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.

1998 • 398 citations

Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion

1996 • 391 citations

Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels

2001 • 375 citations

CaT1 manifests the pore properties of the calcium-release-activated calcium channel

2001 • 350 citations

Voltage-dependent calcium channels: From structure to function

2005 • 341 citations

Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein

1997 • 337 citations

Permeation and Gating Properties of the Novel Epithelial Ca2+ Channel

2000 • 318 citations

Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3

2001 • 313 citations

A novel capacitative calcium entry channel expressed in excitable cells

1998 • 308 citations

Trp12, a novel Trp related protein from kidney

2000 • 303 citations

Coassembly of Trp1 and Trp3 Proteins Generates Diacylglycerol- and Ca2+-sensitive Cation Channels

2000 • 299 citations

Identification of Common Binding Sites for Calmodulin and Inositol 1,4,5-Trisphosphate Receptors on the Carboxyl Termini of Trp Channels

2001 • 296 citations

Molecular Cloning and Functional Characterization of a Novel Receptor-activated TRP Ca2+ Channel from Mouse Brain

1998 • 294 citations

A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.

1996 • 286 citations

Expression of CaT-like, a Novel Calcium-selective Channel, Correlates with the Malignancy of Prostate Cancer

2001 • 280 citations

Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca ²⁺ entry channel

1999 • 278 citations

Expression of TRPC3 in Chinese Hamster Ovary Cells Results in Calcium-activated Cation Currents Not Related to Store Depletion

1997 • 259 citations

Calcitriol Controls the Epithelial Calcium Channel in Kidney

2001 • 257 citations

Molecular Cloning of a Novel Putative Ca2+Channel Protein (TRPC7) Highly Expressed in Brain

1998 • 255 citations

Association of Mammalian Trp4 and Phospholipase C Isozymes with a PDZ Domain-containing Protein, NHERF

2000 • 250 citations

CaT1 and the Calcium Release-activated Calcium Channel Manifest Distinct Pore Properties

2001 • 236 citations

Function and expression of the epithelial Ca2+ channel family: comparison of mammalian ECaC1 and 2

2001 • 234 citations

TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells

2002 • 232 citations

Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform

2001 • 226 citations

Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain

2001 • 219 citations

Localization of the Epithelial Ca2+ Channel in Rabbit Kidney and Intestine

2000 • 218 citations

Molecular Mechanism of Active Ca²⁺ Reabsorption in the Distal Nephron

2002 • 215 citations

Human Calcium Transport Protein CaT1

2000 • 209 citations

Function and expression of the epithelial Ca2+ channel family: comparison of mammalian ECaC1 and 2

2001 • 194 citations

TRP4 (CCE1) Protein Is Part of Native Calcium Release-activated Ca2+-like Channels in Adrenal Cells

2000 • 186 citations

Molecular biology of calcium channels

1995 • 182 citations

Dissociation of the store‐operated calcium current I_CRAC and the Mg‐nucleotide‐regulated metal ion current MagNuM

2002 • 180 citations

Identification of an Aspartic Residue in the P-loop of the Vanilloid Receptor That Modulates Pore Properties

2000 • 180 citations

Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells

1999 • 177 citations

CaT1 Expression Correlates with Tumor Grade in Prostate Cancer

2001 • 177 citations

The Single Pore Residue Asp542 Determines Ca2+ Permeation and Mg2+ Block of the Epithelial Ca2+ Channel

2001 • 172 citations

Constitutive Activity of the Light-Sensitive Channels TRP and TRPL in the Drosophila Diacylglycerol Kinase Mutant, rdgA

2000 • 168 citations

Competitive regulation of CaT-like-mediated Ca ²⁺ entry by protein kinase C and calmodulin

2001 • 165 citations

Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted

2000 • 165 citations

A Rat Kidney-specific Calcium Transporter in the Distal Nephron

2000 • 158 citations

Gating of Store-Operated Channels by Conformational Coupling to Ryanodine Receptors

2000 • 155 citations

Whole‐cell and single channel monovalent cation currents through the novel rabbit epithelial Ca²⁺ channel ECaC

2000 • 155 citations

Expression of Functional Receptor-coupled TRPC3 Channels in DT40 Triple Receptor InsP3 knockout Cells

2001 • 144 citations

Molecular Cloning of an N-terminal Splice Variant of the Capsaicin Receptor

2000 • 142 citations

Differential expression and alternative splicing of TRP channel genes in smooth muscles

2001 • 141 citations

Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression

2000 • 138 citations

Cloning and Functional Expression of Human Short TRP7, a Candidate Protein for Store-operated Ca2+ Influx

2002 • 126 citations

Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3

2000 • 120 citations

Functional significance of human trp1 and trp3 in store-operated Ca²⁺entry in HEK-293 cells

2000 • 120 citations

Pharmacological modulation of monovalent cation currents through the epithelial Ca²⁺ channel ECaC1

2001 • 116 citations

Cloning of a Stretch-inhibitable Nonselective Cation Channel

1999 • 113 citations

Functional Differences between TRPC4 Splice Variants

2002 • 102 citations

Modulation of the epithelial calcium channel, ECaC, by intracellular Ca2+

2001 • 101 citations

The organization of INAD-signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling

1999 • 99 citations

Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis

2001 • 97 citations

Phenotype of a recombinant store‐operated channel: highly selective permeation of Ca²⁺

1999 • 95 citations

Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2

2000 • 86 citations

Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts

1998 • 86 citations

Mechanisms of Renal Calcium Transport

2000 • 70 citations

Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster

1997 • 59 citations

Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2

2000 • 50 citations

Mtr1, a Novel Biallelically Expressed Gene in the Center of the Mouse Distal Chromosome 7 Imprinting Cluster, is a Member of the Trp Gene Family

2000 • 49 citations

INAF, a protein required for transient receptor potential Ca ²⁺ channel function

1999 • 40 citations

The epithelial calcium channel, ECaC1: molecular details of a novel player in renal calcium handling

2001 • 21 citations