Importance of Zinc in the Central Nervous System: The Zinc-Containing Neuron

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

ZINC AND BRAIN INJURY

1998 • 757 citations

ZnT-3, a putative transporter of zinc into synaptic vesicles

1996 • 712 citations

Kainic acid seizures in the rat

1994 • 693 citations

Developmental Neurobiology

1991 • 659 citations

Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders

1997 • 543 citations

A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain

1987 • 525 citations

The role of assembly in insulin's biosynthesis

1998 • 501 citations

ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.

1996 • 447 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study

1985 • 410 citations

Electron microscopical localization of the zinc in hippocampal mossy fibre synapses by a modified sulfide silver procedure

1967 • 393 citations

Mutation in AP-3 δ in the mocha Mouse Links Endosomal Transport to Storage Deficiency in Platelets, Melanosomes, and Synaptic Vesicles

1998 • 393 citations

Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey

1997 • 352 citations

Translocation of zinc may contribute to seizure-induced death of neurons

1989 • 347 citations

GABAA receptor subunits in the rat hippocampus I: Immunocytochemical distribution of 13 subunits

1997 • 338 citations

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

1994 • 329 citations

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

1994 • 325 citations

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat

1990 • 303 citations

AMPA receptor activation potentiates zinc neurotoxicity

1993 • 280 citations

Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease

1998 • 275 citations

Disruption of the Metallothionein-III Gene in Mice: Analysis of Brain Zinc, Behavior, and Neuron Vulnerability to Metals, Aging, and Seizures

1997 • 248 citations

Physical basis of a protein-DNA recognition code

1997 • 246 citations

Chapter 6 Zinc-containing neurons in hippocampus and related CNS structures

1990 • 238 citations

Mammalian Zinc Transporters ,

1998 • 226 citations

Selective release of endogenous zinc from the hippocampal mossy fibers in situ

1987 • 220 citations

Rapid Ca²⁺Entry through Ca²⁺-Permeable AMPA/Kainate Channels Triggers Marked Intracellular Ca²⁺Rises and Consequent Oxygen Radical Production

1998 • 203 citations

Metallothioneins in Brain—The Role in Physiology and Pathology

1997 • 201 citations

Autometallography

1984 • 188 citations

Brief exposure to zinc is toxic to cortical neurons

1986 • 182 citations

Chelation of intracellular zinc triggers apoptosis in mature thymocytes.

1993 • 180 citations

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation

1985 • 179 citations

Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin

1994 • 177 citations

Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study

1988 • 175 citations

Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains

1997 • 171 citations

The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS

1985 • 171 citations

Characterization of Zinc-Induced Neuronal Death in Primary Cultures of Rat Cerebellar Granule Cells

1997 • 142 citations

Enrichment of glutamate in zinc-containing terminals of the cat visual cortex

1992 • 137 citations

Labeling of the neurons of origin of zinc-containing pathways by intraperitoneal injections of sodium selenite

1990 • 113 citations

Alzheimer's Disease, β-Amyloid Protein and Zinc

2000 • 112 citations

Zn2+ permeates Ca2+permeable AMPA/kainate channels and triggers selective neural injury

1995 • 112 citations

Molecular Basis for Differential Inhibition of Glutamate Transporter Subtypes by Zinc Ions

1998 • 107 citations

Distribution of histochemically reactive zinc in the forebrain of the rat

1992 • 106 citations

Release of zinc sulphide accumulations into synaptic clefts after in vivo injection of sodium sulphide

1986 • 104 citations

Zinc Transport in the Brain: Routes of Zinc Influx and Efflux in Neurons

2000 • 94 citations

Effect of diethyldithiocarbamate (DEDTC) on sulphide silver stained boutons reversible blocking of Timm's sulphide silver stain for “heavy” metals in DEDTC treated rats (Light Microscopy)

1973 • 94 citations

Molecular biology of iron and zinc uptake in eukaryotes

1997 • 93 citations

In situ binding of bouton zinc reversibly disrupts performance on a spatial memory task

1990 • 90 citations

Modulation of long-term potentiation in rat hippocampal pyramidal neurons by zinc

1994 • 89 citations

Toward a molecular understanding of zinc metabolism.

1986 • 87 citations

The autometallographic zinc-sulphide method. A new approach involvingin vivo creation of nanometer-sized zinc sulphide crystal lattices in zinc-enriched synaptic and secretory vesicles

1996 • 86 citations

Calcium‐Sensitive Fluorescent Dyes Can Report Increases in Intracellular Free Zinc Concentration in Cultured Forebrain Neurons

1998 • 82 citations

Zinc-containing 7S-NGF complex. Evidence from zinc histochemistry for localization in salivary secretory granules.

1987 • 79 citations

Zinc Ions Prevent Processing of Caspase-3 during Apoptosis Induced by Geranylgeraniol in HL-60 Cells

1998 • 71 citations

Zinc Uptake into Synaptosomes

1988 • 64 citations

Histochemical localization of synaptic zinc in the developing cat visual cortex

1993 • 61 citations

A retrograde transport method for mapping zinc-containing fiber systems in the brain

1990 • 60 citations

Zinc-containing afferent projections to the rat corticomedial amygdaloid complex: A retrograde tracing study

1998 • 56 citations

Cytochemical demonstration of mercury deposits in trout liver and kidney following methyl mercury intoxication: Differentiation of two mercury pools by selenium

1987 • 56 citations

Restraint stress-induced changes in endogenous zinc release from the rat hippocampus

1993 • 52 citations

Rapid disappearance of zinc positive terminals in focal brain ischemia

1998 • 50 citations

Heavy metals in the amygdala of the rat: zinc, lead and copper

1975 • 47 citations

Zinc-containing fiber systems in the cochlear nuclei of the rat and mouse

1988 • 44 citations

Stable-isotope dilution measurement of zinc and lead in rat hippocampus and spinal cord

1982 • 44 citations

Zinc-rich afferents to the rat neocortex: projections to the visual cortex traced with intracerebral selenite injections

1998 • 44 citations

The effect of dietary zinc deficiency on the mossy fiber zinc content of the rat hippocampus

1987 • 43 citations

Kainate-stimulated Zn2+ uptake labels cortical neurons with Ca2+-permeable AMPA/kainate channels

1998 • 43 citations

Proconvulsant action of diethyldithiocarbamate in stimulation of the perforant path

1993 • 42 citations

Autometallographic Silver Enhancement of Zinc Sulfide Crystals Created in Cryostat Sections from Human Brain Biopsies: A New Technique that Makes it Feasible to Demonstrate Zinc Ions in Tissue Sections from Biopsies and Early Autopsy Material

1997 • 42 citations

Zinc containing projections to the bed nucleus of the stria terminalis

1991 • 39 citations

Quantification of vesicular zinc in the rat brain

1988 • 38 citations

Characterization of a plasma membrane zinc transporter in rat brain

1998 • 37 citations

Retrograde tracing of zinc-containing neurons by selenide ions: a survey of seven selenium compounds.

1992 • 37 citations

Effect of metal chelating agents on the direct and seizure-related neuronal death induced by zinc and kainic acid

1998 • 37 citations

Real-time monitoring of the effects of normothermia and hypothermia on extracellular glutamate re-uptake in the rat following global brain ischemia

1997 • 35 citations

Zinc-containing neuronal innervation of the septal nuclei

1993 • 35 citations

Detection of Pathological Zinc Accumulation In Neurons: Methods for Autopsy, Biopsy, and Cultured Tissue

1999 • 34 citations

Diethyldithiocarbamate and dithizone augment the toxicity of kainic acid

1990 • 33 citations

Molecular biology of glutamate receptors. Potentiation of N-methyl-D-aspartate receptor splice variants by zinc.

1994 • 32 citations

On the normal histochemistry of trace metals in the brain.

1975 • 31 citations

[Alzheimer's disease and the zinc theory].

1990 • 31 citations

Distribution of neurons of origin of zinc-containing projections in the amygdala of the rat

1995 • 31 citations

Characterization of N‐(6‐methoxy‐8‐quinolyl)‐p‐toluenesulfonamide for the detection of zinc in living sperm cells

1995 • 31 citations

Callosal neurones give rise to zinc-rich boutons in the rat visual cortex

1995 • 28 citations

Zinc Reversibly Inhibits Steroid Binding to Murine Glucocorticoid Receptor

1997 • 27 citations

Zinc neurotoxicity may contribute to selective neuronal death following transient global cerebral ischemia.

1996 • 24 citations

Zinc-containing innervation of the subicular region in the rat

1995 • 22 citations

Neural cell adhesion molecule, neuron-specific enolase and calcitonin gene-related peptide immunoreactivity in hamster taste buds after chorda tympani/lingual nerve denervation

1998 • 21 citations

Heavy metals in the spinal cord of normal rats and of animals treated with chelating agents: A quantitative (Zinc, copper, and lead) and histochemical study

1978 • 20 citations

Cysteine contributions to metal binding preference for Zn/Cd in the beta-domain of metallothionein

1998 • 19 citations

A zinc-containing fiber system of thalamic origin

1994 • 15 citations

Zinc uptake in five sectors of the rat gastrointestinal tract: kinetic study in the whole colon.

1996 • 11 citations

Selenium in the anterior pituitary

1985 • 10 citations

Autometallography used as a histochemical indicator of lysosome function in cultured cells

1990 • 8 citations

Kinetics of the Intestinal Uptake of Zinc Acexamate in Normal and Zinc-depleted Rats

1990 • 4 citations