Copper toxicity, oxidative stress, and antioxidant nutrients

Modern Nutrition in Health and Disease.

1988 • 3,468 citations

The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate

1993 • 2,350 citations

Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc : a report of the Panel on Micronutrients, Subcommittees on Upper Reference Levels of Nutrients and of Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine

2001 • 1,713 citations

Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

1993 • 1,665 citations

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

1997 • 1,642 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

The Antioxidant Properties of Zinc

2000 • 1,264 citations

Copper biochemistry and molecular biology

1996 • 1,171 citations

Essentiality of copper in humans

1998 • 1,013 citations

Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid

1996 • 861 citations

Oxidative stress in Alzheimer’s disease

2000 • 857 citations

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

1997 • 719 citations

Handbook of Vitamins

1991 • 616 citations

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

2000 • 526 citations

Copper in disorders with neurological symptoms: Alzheimer’s, Menkes, and Wilson diseases

2001 • 478 citations

Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

1992 • 463 citations

Vitamin E and oxidative stress

1991 • 461 citations

Manifestations of copper excess

1998 • 369 citations

IRON IN NUTRITION VII. COPPER AS A SUPPLEMENT TO IRON FOR HEMOGLOBIN BUILDING IN THE RAT

2009 • 362 citations

Human whole-body copper metabolism

1998 • 299 citations

A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+

2000 • 285 citations

A Critical Overview of the Chemistry of Copper-Dependent Low Density Lipoprotein Oxidation: Roles of Lipid Hydroperoxides, α-Tocopherol, Thiols, and Ceruloplasmin

2001 • 259 citations

Homocysteine potentiates copper‐ and amyloid beta peptide‐mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's‐type neurodegenerative pathways

2001 • 258 citations

Metal-Induced Hepatotoxicity

1996 • 249 citations

Requirements and toxicity of essential trace elements, illustrated by zinc and copper

1995 • 233 citations

Wilson disease and idiopathic copper toxicosis

1996 • 231 citations

COPPER DEFICIENCY IN INFANCY

1964 • 227 citations

Oxidative Stress and Motor Neurone Disease

1999 • 220 citations

Clinical, morphologic, and chemical studies on copper toxicosis of Bedlington Terriers.

1979 • 189 citations

Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits

1992 • 165 citations

Liver copper storage and transport during development: implications for cytotoxicity

1996 • 165 citations

Role of copper in Indian childhood cirrhosis

1998 • 159 citations

Reduction of Copper, but Not Iron, by Human Low Density Lipoprotein (LDL)

1995 • 152 citations

Vascular Superoxide Dismutase Deficiency Impairs Endothelial Vasodilator Function Through Direct Inactivation of Nitric Oxide and Increased Lipid Peroxidation

1997 • 147 citations

Autoradiographic Analysis of Gonadotropin Binding to Rat Ovarian Tissue Sections

1973 • 141 citations

Covalent modification of guanine bases in double-stranded DNA. The 1.2-A Z-DNA structure of d(CGCGCG) in the presence of CuCl2.

1991 • 140 citations

Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload

1990 • 137 citations

Copper absorption, excretion, and retention by young men consuming low dietary copper determined by using the stable isotope 65Cu

1998 • 134 citations

Clinical conditions altering copper metabolism in humans

1998 • 126 citations

Copper neurotoxicity is dependent on dopamine‐mediated copper uptake and one‐electron reduction of aminochrome in a rat substantia nigra neuronal cell line

2001 • 125 citations

Protective effect of zinc supplementation against copper toxicosis in sheep

1976 • 117 citations

Safety guidelines for copper in water

1998 • 111 citations

Idiopathic copper toxicosis

1998 • 110 citations

Identification of a Novel High Affinity Copper Transport Complex in the Fission Yeast Schizosaccharomyces pombe

2001 • 108 citations

α-Tocopherol Induces Oxidative Damage to DNA in the Presence of Copper(II) Ions

1998 • 106 citations

[7] Measurement of iron and copper in biological systems: Bleomycin and copper-phenanthroline assays

1994 • 105 citations

Drinking-Water-Induced Copper Intoxication in a Vermont Family

1984 • 100 citations

Biodegradation of Restorative Metallic Systems

1992 • 100 citations

Vitamin E protects against impairment of endothelium-mediated relaxations in cholesterol-fed rabbits.

1994 • 99 citations

Treatment of Wilson's disease with zinc XVI: Treatment during the pediatric years

2001 • 97 citations

Oxidized low density lipoprotein induces activation of the transcription factor NFκB in fibroblasts, endothelial and smooth muscle cells

1996 • 93 citations

Copper status of young men consuming a low-copper diet

1997 • 93 citations

Effects of copper on mammalian cell components

1989 • 89 citations

Effect of Varying Ascorbic Acid Intakes on Copper Absorption and Ceruloplasmin Levels of Young Men

1987 • 88 citations

Menkes syndrome and animal models

1998 • 88 citations

Other endothelium-derived vasoactive factors

1993 • 86 citations

Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid

2001 • 86 citations

Present interpretation of the role of copper in Indian childhood cirrhosis

1996 • 85 citations

Host Defenses against Copper Toxicity

1990 • 79 citations

Inhibition of copper-induced LDL oxidation by vitamin C is associated with decreased copper-binding to LDL and 2-oxo-histidine formation

1999 • 79 citations

The Copper Transport Protein Atox1 Promotes Neuronal Survival

2000 • 78 citations

Essential and toxic trace elements in human health and disease: an update.

1993 • 76 citations

A Copper Deficiency in Neonatal Pigs Induced by a High Zinc Maternal Diet

1983 • 75 citations

Interrelationship of Dietary Ascorbic Acid and Iron on the Tissue Distribution of Ascorbic Acid, Iron and Copper in Female Guinea Pigs

1980 • 74 citations

Hydroxyl radical and singlet oxygen production and DNA damage induced by carcinogenic metal compounds and hydrogen peroxide

1989 • 73 citations

Copper deficiency affects selenoglutathione peroxidase and selenodeiodinase activities and antioxidant defense in weanling rats

1994 • 73 citations

Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats

1993 • 73 citations

Is non-Indian childhood cirrhosis caused by excess dietary copper?

1994 • 73 citations

Red Wine Antioxidants Bind to Human Lipoproteins and Protect Them from Metal Ion-Dependent and -Independent Oxidation

2001 • 73 citations

Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats.

2000 • 72 citations

Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes.

2001 • 72 citations

Influence of dietary rapeseed oil, vitamin E, and copper on the performance and the antioxidative and oxidative status of pigs.

1999 • 71 citations

Inverse deuterium kinetic isotope effect for peroxidation in human low‐density lipoprotein (LDL): a simple test for tocopherol‐mediated peroxidation of LDL lipids

1995 • 70 citations

In Vivo Oxidative Modification of Erythrocyte Membrane Proteins in Copper Deficiency

1997 • 69 citations

Effect of copper deficiency on oxidative DNA damage in Jurkat T-lymphocytes

2000 • 67 citations

Cu(II)/H₂O₂-Induced DNA Damage Is Enhanced by Packaging of DNA as a Nucleosome

2001 • 66 citations

Comparative effects of metal chelating agents on the neuronal cytotoxicity induced by copper (Cu+2), iron (Fe+3) and zinc in the hippocampus

2001 • 65 citations

Adverse effects of high dietary iron and ascorbic acid on copper status in copper-deficient and copper-adequate rats

1988 • 64 citations

Physiological Ligands for Copper and Zinc

1983 • 64 citations

Copper‐Dependent Oxidative Stress and Neurodegeneration

2000 • 62 citations

Effect of dietary copper and vitamin E supplementation, and extensive feeding with acorn and grass on longissimus muscle composition and susceptibility to oxidation in Iberian pigs

2001 • 62 citations

Copper nutriture, bioavailability, and the influence of dietary factors.

1988 • 61 citations

Acute Copper Intoxication

1972 • 60 citations

Effects of a carotene-deficient diet on measures of oxidative susceptibility and superoxide dismutase activity in adult women

1994 • 59 citations

Hepatic Copper Accumulation Induces DNA Strand Breaks in the Liver Cells of Long-Evans Cinnamon Strain Rats

2000 • 57 citations

Ceruloplasmin Copper Induces Oxidant Damage by a Redox Process Utilizing Cell-Derived Superoxide as Reductant

1998 • 57 citations

Electron spin resonance evidence for free radical generation in copper-treated vitamin E- and selenium-deficient rats: in vivo spin-trapping investigation.

1993 • 55 citations

Copper-associated liver disease in childhood

1995 • 54 citations

Red Wine Inhibits the Cell-Mediated Oxidation of LDL and HDL

1999 • 54 citations

Systemic Absorption of Intrauterine Copper

1972 • 52 citations

Amyloid precursor protein, copper and Alzheimer's disease

1997 • 51 citations

Simulation of the Induction of Oxidation of Low-Density Lipoprotein by High Copper Concentrations: Evidence for a Nonconstant Rate of Initiation

1997 • 50 citations

Relationship between Oxidative Stress and Heme Oxygenase Induction by Copper Sulfate

1997 • 47 citations

Effects of Varying Dietary Iron on the Expression of Copper Deficiency in the Growing Rat: Anemia, Ferroxidase I and II, Tissue Trace Elements, Ascorbic Acid, and Xanthine Dehydrogenase

1985 • 47 citations

Enhanced Susceptibility to Oxidation and Diminished Vitamin E Content of LDL from Patients with Stable Coronary Artery Disease

2001 • 47 citations

Protective Effects of Aspirin and Vitamin E (α-Tocopherol) against Copper- and Cadmium-Induced Toxicity

2001 • 47 citations

Copper deficiency and erythrocuprein (2Cu,2Zn-superoxide dismutase)

1976 • 44 citations

Ascorbic acid oxidation: A potential cause of the elevated severity of atherosclerosis in diabetes mellitus?

1992 • 44 citations

Effect of ascorbic acid on copper and cholesterol in adult cynomolgus monkeys fed a diet marginal in copper

1981 • 42 citations

Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia

2001 • 41 citations

ACUTE COPPER POISONING

1960 • 41 citations

Interaction of Dietary Carbohydrate, Ascorbic Acid and Copper with the Development of Copper Deficiency in Rats

1986 • 40 citations

Kinetic analysis of copper-induced peroxidation of HDL, autoaccelerated and tocopherol-mediated peroxidation

2000 • 38 citations

Effects of Dietary Copper, Cadmium, Iron, Molybdenum and Manganese on Selenium Utilization by the Rat

1986 • 38 citations

Effects of Se, Cu and Se + vitamin E deficiency on the activities of CuZnSOD, GSH‐Px, CAT and LPO levels in chicken erythrocytes

2001 • 38 citations

α-Tocopherol Ameliorates Oxidant Injury in Isolated Copper-Overloaded Rat Hepatocytes

1996 • 38 citations

Dietary Vitamin C Improves the Survival of Mice

1984 • 38 citations

Effect of excess dietary copper, iron or zinc on the tocopherol and selenium status of growing pigs.

1990 • 36 citations

Wilson disease and canine copper toxicosis

1998 • 36 citations

The Role of Copper Reduction by α-Tocopherol in Low-Density Lipoprotein Oxidation

1997 • 36 citations

Differential cell death induced by salsolinol with and without copper: possible role of reactive oxygen species.

2001 • 36 citations

A simple, highly sensitive and improved method for the measurement of bleomycin-detectable iron: the ‘catalytic iron index’ and its value in the assessment of iron status in haemochromatosis

2001 • 34 citations

Effect of Age and Sex on Liver Damage Due to Excess Dietary Copper in Fischer 344 Rats

2000 • 34 citations

Influence of ascorbic acid supplementation on copper metabolism in rats

1992 • 33 citations

α‐Tocopherol mediated peroxidation in the copper (II) and met myoglobininduced oxidation of human low density lipoprotein: The influence of lipid hydroperoxides

1995 • 33 citations

A Postabsorption Effect of L-Ascorbic Acid on Copper Metabolism in Chicks

1981 • 32 citations

Long term survival in Indian childhood cirrhosis treated with D-penicillamine.

1996 • 32 citations

Antioxidant enzyme gene transcription in copper-deficient rat liver

1996 • 30 citations

Effects of dietary vitamin C and E supplementation on the copper mediated oxidation of HDL and on HDL mediated cholesterol efflux

1996 • 29 citations

Trace elements and DNA damage

2001 • 29 citations

The antioxidant effect of DL-α-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats

2001 • 28 citations

Changes in free radical-metabolizing enzymes and lipid peroxides in the liver of Long-Evans with cinnamon-like coat color rats

1995 • 27 citations

Comparison of the effects of dietary vitamin E on in vivo and in vitro parameters of lipid peroxidation in the rabbit

1995 • 24 citations

The transport of copper.

1993 • 24 citations

Decreased Brain Ascorbate Levels in Copper-Deficient Mice and in Brindled Mice

1983 • 22 citations

New trends in the use of metals in jewellery

1991 • 22 citations

Copper Absorption as Affected by Supplemental Calcium, Magnesium, Manganese, Selenium and Potassium

1989 • 22 citations

Proline, ascorbic acid, or thioredoxin affect jaundice and mortality in long evans cinnamon rats

1995 • 22 citations

Gastrointestinal upsets and new copper plumbing--is there a connection?

1998 • 20 citations

Dietary ascorbic acid lowers the concentration of soluble copper in the small intestinal lumen of rats

1994 • 20 citations

[Oxidative effect of hepatic copper overload].

1998 • 20 citations

α-Tocopherol supplementation of macrophages does not influence their ability to oxidize LDL

1998 • 19 citations

Effects of dietary vitamin E on clinical course and plasma glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities in hereditary hepatitis of LEC rats.

1993 • 17 citations

Effect of Dietary Copper on Selenium Toxicity in Fischer 344 Rats

2000 • 15 citations

Aspirin reduces blood cholesterol in copper-deficient rats: A potential antioxidant agent?

2001 • 15 citations

Influence of ascorbic acid on cytotoxic activity of copper and iron ions in vitro.

2001 • 15 citations

α -Tocopherol deficiency fails to aggravate toxic liver injury but liver injury causes α -tocopherol retention

1992 • 12 citations

Ascorbate (vitamin c) and dehydroascorbate stimulation of copper induced hemolysis protective action of ceruloplasmin, albumin and apotransferrin

1984 • 10 citations

Changes in DNA Conformation Induced by Gamma Irradiation in the Presence of Copper

2001 • 10 citations

The lowering effect of high copper intake on selenium retention in weanling rats depends on the selenium concentration of the diet

2001 • 9 citations

Autoxidation of Amyloid Precursor Protein and Formation of Reactive Oxygen Species

1999 • 9 citations

Ascorbate-Induced High-Affinity Binding of Copper to Cytosolic Proteins

2001 • 9 citations

The failure of selenium supplementation to prevent copper-induced liver damage in Fischer 344 rats.

2001 • 8 citations

Effect of ascorbic acid administration on copper-induced changes of rat brain hypothalamic catecholamine contents

1988 • 8 citations

The effect of ascorbic acid on copper-induced oxidative changes in the erythrocytes of rats, sheep, and normal humans

1983 • 8 citations

Chronic vitamin E inadequacy and thermally treated oils affect the synthesis of hepatic metallothionein isoforms

2000 • 4 citations

Studies on the influence of a Se-restricted diet on the effects of long-term increased copper intake in guinea pigs

2000 • 1 citations