Movement of zinc and its functional significance in the brain

Trace Elements in Human and Animal Nutrition

1963 • 4,642 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala

1994 • 2,309 citations

Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus

1986 • 1,978 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins

1992 • 966 citations

Long-term potentiation and NMDA receptors in rat visual cortex

1987 • 953 citations

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1987 • 852 citations

Flux coupling in a neuronal glutamate transporter

1996 • 835 citations

Importance of Zinc in the Central Nervous System: The Zinc-Containing Neuron

2000 • 834 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

ZINC AND BRAIN INJURY

1998 • 757 citations

ZnT-3, a putative transporter of zinc into synaptic vesicles

1996 • 712 citations

Two components of long-term potentiation induced by different patterns of afferent activation

1990 • 704 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors

1997 • 629 citations

Handbook on toxicity of inorganic compounds

1990 • 611 citations

MT-III, a brain-specific member of the metallothionein gene family.

1992 • 558 citations

Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders

1997 • 543 citations

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT 3 gene

1999 • 534 citations

Impaired auditory recognition of fear and anger following bilateral amygdala lesions

1997 • 523 citations

Physiology of the choroid plexus.

1971 • 495 citations

The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses

2000 • 477 citations

Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry

1997 • 463 citations

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

1993 • 461 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study

1985 • 410 citations

Preferential Zn ²⁺ influx through Ca ²⁺ -permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

1999 • 408 citations

A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission

1991 • 378 citations

Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+

1990 • 370 citations

Dihydropyridine‐sensitive low‐threshold calcium channels in isolated rat hypothalamic neurones.

1989 • 357 citations

Zinc deficiency in man

1972 • 356 citations

Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey

1997 • 352 citations

Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat

1983 • 351 citations

Translocation of zinc may contribute to seizure-induced death of neurons

1989 • 347 citations

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

2000 • 339 citations

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

1994 • 329 citations

Regulation of the zinc transporter ZnT-1 by dietary zinc

1998 • 306 citations

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat

1990 • 303 citations

Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons

1990 • 302 citations

Functions of trace elements in brain metabolism.

1987 • 297 citations

The experimental production of zinc deficiency in the rat

1970 • 287 citations

Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury

2000 • 285 citations

Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels

1994 • 284 citations

AMPA receptor activation potentiates zinc neurotoxicity

1993 • 280 citations

Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals

1999 • 270 citations

Essential and Toxic Trace Elements in Human Health and Disease

1989 • 266 citations

Control of Voltage-Independent Zinc Inhibition of NMDA Receptors by the NR1 Subunit

1998 • 263 citations

Disruption of the Metallothionein-III Gene in Mice: Analysis of Brain Zinc, Behavior, and Neuron Vulnerability to Metals, Aging, and Seizures

1997 • 248 citations

Zinc neurotoxicity in cortical cell culture

1988 • 244 citations

Heavy metals in the brain. A light microscope study of the rat with Timm's sulphide silver method. Methodological considerations and cytological and regional staining patterns.

1973 • 240 citations

Chapter 6 Zinc-containing neurons in hippocampus and related CNS structures

1990 • 238 citations

Competition for zinc among serum albumin and amino acids

1972 • 235 citations

Developmental Zinc Deficiency and Behavior

1995 • 231 citations

Accumulation of Zinc in Degenerating Hippocampal Neurons of ZnT3-Null Mice after Seizures: Evidence against Synaptic Vesicle Origin

2000 • 227 citations

Mammalian Zinc Transporters ,

1998 • 226 citations

Zinc-Containing Neurons

1994 • 224 citations

Brain trace element concentrations in aging

1984 • 223 citations

Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors

1994 • 223 citations

Selective release of endogenous zinc from the hippocampal mossy fibers in situ

1987 • 220 citations

History of Zinc as Related to Brain Function

2000 • 216 citations

Localization and Release of Glutamic Acid in Relation to the Hippocampal Mossy Fibre Pathway

1973 • 215 citations

Differential Sensitivity of RecombinantN-Methyl-d-Aspartate Receptor Subtypes to Zinc Inhibition

1997 • 210 citations

Binding of zinc to amino acids and serum proteins in vitro.

1970 • 203 citations

Neuroprotection and Neuronal Differentiation Studies Using Substantia Nigra Dopaminergic Cells Derived from Transgenic Mouse Embryos

1999 • 196 citations

Brain trace elements in Alzheimer's disease.

1986 • 194 citations

Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor

1999 • 182 citations

Iron, Transferrin, and Ferritin in the Rat Brain During Development and Aging

1994 • 179 citations

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation

1985 • 179 citations

ELECTRON MICROSCOPIC DEMONSTRATION OF ZINC IN THE HIPPOCAMPAL FORMATION USING TIMM'S SULFIDE-SILVER TECHNIQUE

1969 • 177 citations

Zn²⁺ entry produces oxidative neuronal necrosis in cortical cell cultures

1999 • 177 citations

Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study

1988 • 175 citations

The computed distribution of copper(II) and zinc(II) ions among seventeen amino acids present in human blood plasma

1971 • 171 citations

The inhibition of single N‐methyl‐D‐aspartate‐activated channels by zinc ions on cultured rat neurones.

1990 • 170 citations

The concentrations of free Mg2+ and free Zn2+ in equine blood plasma.

1987 • 170 citations

Zinc and Alzheimer's disease: is there a direct link?

1997 • 169 citations

Imaging free zinc in synaptic terminals in live hippocampal slices

1997 • 167 citations

Metal ions and synaptic transmission: Think zinc

1997 • 162 citations

Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ

1985 • 154 citations

Biological half-lives of zinc and manganese in rat brain

1995 • 152 citations

ZINC IN MATURING RAT BRAIN: HIPPOCAMPAL CONCENTRATION AND LOCALIZATION¹

1972 • 150 citations

Clinical, Biochemical And Nutritional Spectrum Of Zinc Deficiency In Human Subjects: An Update

2009 • 146 citations

Expression of Zinc Transporter Gene, ZnT-1, Is Induced after Transient Forebrain Ischemia in the Gerbil

1997 • 140 citations

Chronic Zinc Deficiency Alters Neuronal Function of Hippocampal Mossy Fibers

1979 • 134 citations

Zinc and gene expression

1981 • 133 citations

A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.

1992 • 132 citations

Histochemically Reactive Zinc in Plaques of the Swedish Mutant β-Amyloid Precursor Protein Transgenic Mice

1999 • 132 citations

Uptake and Distribution of Iron and Transferrin in the Adult Rat Brain

1992 • 129 citations

Learning and memory impairment in adult rats due to severe zinc deficiency during lactation

1983 • 127 citations

Induction of an Immediate Early Gene egr‐1 by Zinc Through Extracellular Signal‐Regulated Kinase Activation in Cortical Culture

1999 • 127 citations

Mammalian voltage-activated calcium channel currents are blocked by Pb2+, Zn2+, and Al3+

1994 • 123 citations

Cerebrospinal fluid trace element content in dementia

1983 • 120 citations

Zinc requirements and zinc intakes of breast-fed infants

1986 • 119 citations

Threshold channels—a novel type of sodium channel in squid giant axon

1984 • 113 citations

Zn2+ permeates Ca2+permeable AMPA/kainate channels and triggers selective neural injury

1995 • 112 citations

Differential effect of zinc on the vertebrate GABA_A‐receptor complex

1990 • 112 citations

Alzheimer's Disease, β-Amyloid Protein and Zinc

2000 • 112 citations

[3H]MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence for multiple regulatory sites

1988 • 110 citations

Learning and memory disabilities in young adult rats from mildly zinc deficient dams

1986 • 109 citations

Zn2+ potentiates excitatory action of ATP on mammalian neurons.

1993 • 107 citations

Release of zinc sulphide accumulations into synaptic clefts after in vivo injection of sodium sulphide

1986 • 104 citations

Noncompetitive inhibition of gamma-aminobutyric acidA channels by Zn.

1991 • 104 citations

Separating dual effects of zinc at recombinant N-methyl-d-aspartate receptors

1996 • 104 citations

Brain uptake of trace metals, zinc and manganese, in rats

1994 • 103 citations

Zinc Transport in the Brain: Routes of Zinc Influx and Efflux in Neurons

2000 • 94 citations

Effect of diethyldithiocarbamate (DEDTC) on sulphide silver stained boutons reversible blocking of Timm's sulphide silver stain for “heavy” metals in DEDTC treated rats (Light Microscopy)

1973 • 94 citations

Effects of dietary zinc status on seizure susceptibility and hippocampal zinc content in theEl (epilepsy) mouse

1990 • 93 citations

Measurement of free Zn2+ ion concentration with the fluorescent probe mag-fura-2 (furaptra)

1993 • 92 citations

Growth and body composition of periurban Guatemalan children in relation to zinc status: a cross-sectional study

1993 • 91 citations

In situ binding of bouton zinc reversibly disrupts performance on a spatial memory task

1990 • 90 citations

Modulation by zinc of the glutamate transporters in glial cells and cones isolated from the tiger salamander retina

1998 • 87 citations

Zinc‐Induced Seizures: A New Experimental Model of Epilepsy

1983 • 87 citations

Nutritional Modulation of Neural Function

1988 • 85 citations

Severe Zinc Deficiency: Effects on the Distribution of Nine Elements (Potassium, Phosphorus, Sodium, Magnesium, Calcium, Iron, Zinc, Copper and Manganese) in Regions of the Rat Brain

1983 • 82 citations

The Development of the Blood-Brain Barrier

1968 • 82 citations

Studies of marginal zinc deprivation in rhesus monkeys: Infant behavior

1985 • 81 citations

The selective inhibition of hippocampal glutamic acid decarboxylase in zinc-induced epileptic seizures

1982 • 80 citations

Zinc deficiency in pregnant rhesus monkeys: effects on behavior of infants

1978 • 79 citations

A heart-like Na+ current in the medial entorhinal cortex

1993 • 78 citations

Relationship between brain zinc and transient learning impairment of adult rats fed zinc-deficient diet

2000 • 76 citations

Growth in children from the Wosera subdistrict, Papua New Guinea, in relation to energy and protein intakes and zinc status

1991 • 73 citations

Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation

1994 • 73 citations

Zinc metabolism in normal and zinc-deficient rat brain

1984 • 71 citations

Manganese uptake into rat brain during development and aging

1999 • 68 citations

Neurobiology of the Trace Elements

1983 • 65 citations

Zinc Uptake into Synaptosomes

1988 • 64 citations

Glutamate triggers preferential Zn2+ flux through Ca2+ permeable AMPA channels and consequent ROS production

1999 • 62 citations

A retrograde transport method for mapping zinc-containing fiber systems in the brain

1990 • 60 citations

Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. III. Impaired dendritic differentiation of basket and stellate cells

1984 • 57 citations

Zinc-containing afferent projections to the rat corticomedial amygdaloid complex: A retrograde tracing study

1998 • 56 citations

Zinc modulation of a transient potassium current and histochemical localization of the metal in neurons of the suprachiasmatic nucleus.

1993 • 56 citations

Zinc reduces dentate granule cell hyperexcitability in epileptic humans

1995 • 55 citations

The effect of late prenatal and/or early postnatal zinc deficiency on the development and some biochemical aspects of the cerebellum and hippocampus in rats

1981 • 55 citations

Biochemical characterization of a metallothionein-like protein in rat brain

1986 • 54 citations

Kindled seizure induction alters and is altered by zinc absorption

1986 • 54 citations

Divalent transition-metal ions (Cu2+ and Zn2+) in the brains of epileptogenic and normal mice

1983 • 53 citations

Restraint stress-induced changes in endogenous zinc release from the rat hippocampus

1993 • 52 citations

Hormonal effects of zinc on growth in children

1992 • 51 citations

Localization in rat brain of the trace metals, zinc and manganese, after intracerebroventricular injection

1994 • 50 citations

Active zinc binding sites of zinc metalloenzymes.

1992 • 49 citations

Interaction of zinc with ionotropic and metabotropic glutamate receptors in rat hippocampal slices

1993 • 47 citations

Calculations of the Distribution of Zinc in a Computer Model of Human Serum

1989 • 46 citations

Effects of amino acids on zinc transport in rat erythrocytes.

1992 • 46 citations

Manganese concentration in rat brain: manganese transport from the peripheral tissues

1998 • 46 citations

Zinc content in discrete hippocampal and amygdaloid areas of the epilepsy (El) mouse and normal mice

1988 • 45 citations

Modulation of gating of cloned rat and human K+ channels by micromolar Zn2+.

1993 • 45 citations

Responses of pyriform cortex neurons to excitatory amino acids: Voltage dependence, conductance changes, and effects of divalent cations

1987 • 44 citations

Kainate-stimulated Zn2+ uptake labels cortical neurons with Ca2+-permeable AMPA/kainate channels

1998 • 43 citations

Effects of the intertrial interval on taste-aversion learning in rats

1980 • 43 citations

The effect of dietary zinc deficiency on the mossy fiber zinc content of the rat hippocampus

1987 • 43 citations

Proconvulsant action of diethyldithiocarbamate in stimulation of the perforant path

1993 • 42 citations

Distribution of Cu and Zn in human brain tissue

1974 • 42 citations

Zinc deficiency: Effects on brain and behavior of rats and Rhesus monkeys

1977 • 42 citations

Change of zinc distribution in rat brain with increasing age

1997 • 40 citations

Serum trace elements in children receiving long-term parenteral nutrition

1986 • 39 citations

Transport of Zinc‐65 at the Blood‐Brain Barrier During Short Cerebrovascular Perfusion in the Rat: Its Enhancement by Histidine

1994 • 38 citations

The effect of histidine and cysteine on zinc influx into rat and human erythrocytes.

1995 • 37 citations

Induction by Synaptic Zinc of Heat Shock Protein-70 in Hippocampus after Kainate Seizures

2000 • 37 citations

Characterization of a plasma membrane zinc transporter in rat brain

1998 • 37 citations

Zinc transport in the rat olfactory system

1997 • 36 citations

Effects of prenatal nutritional deficiency on affiliation and aggression in rats☆

1978 • 35 citations

Accumulation of Zinc in Mouse Brain

1968 • 34 citations

⁶⁵Zn Uptake from Blood into Brain in the Rat

1991 • 34 citations

Multiple actions of zinc on transmitter release at mouse end-plates

1990 • 33 citations

Release of zinc from the brain of El (epilepsy) mice during seizure induction

1999 • 33 citations

Effect of Zinc Deficiency from Day 18 of Gestation and/or during Lactation on the Development of Some Rat Brain Enzymes

1974 • 33 citations

A heavy metal marker of the developing striatal mosaic

1989 • 33 citations

Functions of the hippocampal system

1980 • 30 citations

Uptake and subcellular distribution of 65zinc in brain structures during the postnatal development of the rat

1984 • 28 citations

Blood-brain exchange routes and distribution of65Zn in rat brain

1992 • 27 citations

Zinc and the Central Nervous System

2003 • 27 citations

Behavioral Changes Accompanying Zinc Deficiency in Animals

2003 • 27 citations

65Zinc uptake from blood into brain and other tissues in the rat

1990 • 26 citations

Chelation of zinc by diethyldithiocarbamate facilitates bursting induced by mixed antidromic plus orthodromic activation of mossy fibers in hippocampal slices

1993 • 26 citations

Effects of moderate zinc deficiency on cognitive performance in young adult rats

1982 • 25 citations

Role of zinc released by stimulation in rat amygdala

1999 • 25 citations

Zinc and Seizure Mechanisms

1988 • 24 citations

Zinc, total protein, and albumin in CSF of patients with cerebrovascular diseases

2009 • 23 citations

Malnutrition and Behavior: the Performance Versus Learning Problem Revisited

1980 • 23 citations

Zinc enhances ionic currents induced in skate Mϋller (glial) cells by the inhibitory neurotransmitter GABA

1996 • 22 citations

Zinc distribution in the brain of Nagase analbuminemic rat and enlargement of the ventricular system

1997 • 19 citations

65Zn localization in rat brain after intracerebroventricular injection of 65Zn-histidine

2000 • 19 citations

Zinc transport from the striatum and substantia nigra

1998 • 19 citations

Effects of histidine on tissue zinc distribution in rats

1992 • 15 citations

Zinc deficiency-induced trace element concentration and localization changes in the central nervous system of albino rat during postnatal development

1982 • 15 citations

Trace Elements (Cu, Fe, Mg, Zn) of the Brain during Childhood¹

1974 • 14 citations

Zinc potentiation of neurotransmission and inhibition of background cationic conductance in rat cultured hippocampal neurones.

1995 • 13 citations

An autoradiographic study on the fate of 65Zn in zinc-rich tissues in some rodents.

1979 • 13 citations

Zinc transport and metallothionein induction in primary cultures of rabbit kidney proximal cells

1994 • 12 citations

Influence of Histidine on Zinc Transport into Rat Brain.

2000 • 8 citations

Trace Metal Transport at the Blood-Brain Barrier

1992 • 7 citations