The trp ion channel family

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

2002 • 2,513 citations

A TRP Channel that Senses Cold Stimuli and Menthol

2002 • 2,182 citations

Calcium signaling

1995 • 1,905 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

Regulation of Phosphoinositide-Specific Phospholipase C

2001 • 1,604 citations

A capsaicin-receptor homologue with a high threshold for noxious heat

1999 • 1,547 citations

The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway

2001 • 1,532 citations

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

1999 • 1,456 citations

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

2000 • 1,348 citations

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

2001 • 1,240 citations

Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C

2000 • 986 citations

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

2000 • 982 citations

LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

2001 • 900 citations

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

2001 • 877 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

Induction of vanilloid receptor channel activity by protein kinase C

2000 • 814 citations

LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death

2002 • 794 citations

TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain

2001 • 737 citations

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors

1992 • 732 citations

TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities

2001 • 714 citations

trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry

1996 • 688 citations

The MutT Proteins or “Nudix” Hydrolases, a Family of Versatile, Widely Distributed, “Housecleaning” Enzymes

1996 • 671 citations

TRPC1, a human homolog of a Drosophila store-operated channel.

1995 • 623 citations

Functional interaction between InsP3 receptors and store-operated Htrp3 channels

1998 • 620 citations

Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption

1999 • 610 citations

Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.

2001 • 597 citations

The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular α ₁ -Adrenoceptor–Activated Ca ²⁺ -Permeable Cation Channel

2001 • 596 citations

Molecular Identification of the Apical Ca2+Channel in 1,25-Dihydroxyvitamin D3-responsive Epithelia

1999 • 587 citations

Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice

2001 • 567 citations

CALCIUM CHANNELS: Mechanisms of Selectivity, Permeation, and Block

1987 • 528 citations

Visual transduction in Drosophila

2001 • 510 citations

The TRPM7 channel is inactivated by PIP2 hydrolysis

2002 • 509 citations

From worm to man: three subfamilies of TRP channels

2000 • 490 citations

Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

1999 • 473 citations

Molecular and Functional Characterization of a Novel Mouse Transient Receptor Potential Protein Homologue TRP7

1999 • 451 citations

TRP2: A candidate transduction channel for mammalian pheromone sensory signaling

1999 • 440 citations

Immunocyte Ca ²⁺ Influx System Mediated by LTRPC2

2001 • 434 citations

Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5

2000 • 422 citations

Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.

1989 • 402 citations

Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.

1998 • 398 citations

Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion

1996 • 391 citations

Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels

2001 • 375 citations

CaT1 manifests the pore properties of the calcium-release-activated calcium channel

2001 • 350 citations

Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF

1999 • 343 citations

Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein

1997 • 337 citations

Permeation and Gating Properties of the Novel Epithelial Ca2+ Channel

2000 • 318 citations

Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3

2001 • 313 citations

Coassembly of TRP and TRPL Produces a Distinct Store-Operated Conductance

1997 • 310 citations

A novel capacitative calcium entry channel expressed in excitable cells

1998 • 308 citations

Coassembly of Trp1 and Trp3 Proteins Generates Diacylglycerol- and Ca2+-sensitive Cation Channels

2000 • 299 citations

Molecular Cloning and Functional Characterization of a Novel Receptor-activated TRP Ca2+ Channel from Mouse Brain

1998 • 294 citations

Visual Transduction in Drosophila

1999 • 288 citations

A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.

1996 • 286 citations

Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca ²⁺ entry channel

1999 • 278 citations

Crystal Structure of the Atypical Protein Kinase Domain of a TRP Channel with Phosphotransferase Activity

2001 • 268 citations

Expression of TRPC3 in Chinese Hamster Ovary Cells Results in Calcium-activated Cation Currents Not Related to Store Depletion

1997 • 259 citations

Molecular Cloning of a Novel Putative Ca2+Channel Protein (TRPC7) Highly Expressed in Brain

1998 • 255 citations

Association of Mammalian Trp4 and Phospholipase C Isozymes with a PDZ Domain-containing Protein, NHERF

2000 • 250 citations

Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform

2001 • 226 citations

InsP3 Receptor Is Essential for Growth and Differentiation but Not for Vision in Drosophila

1997 • 222 citations

Melastatin Expression and Prognosis in Cutaneous Malignant Melanoma

2001 • 219 citations

Human Calcium Transport Protein CaT1

2000 • 209 citations

Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome Reaction

2001 • 202 citations

Muscarinic, alpha‐adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland.

1977 • 197 citations

Calcium Influx via TRP Channels Is Required to Maintain PIP2 Levels in Drosophila Photoreceptors

2001 • 195 citations

Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells

1999 • 177 citations

The Single Pore Residue Asp542 Determines Ca2+ Permeation and Mg2+ Block of the Epithelial Ca2+ Channel

2001 • 172 citations

A Rat Kidney-specific Calcium Transporter in the Distal Nephron

2000 • 158 citations

Whole‐cell and single channel monovalent cation currents through the novel rabbit epithelial Ca²⁺ channel ECaC

2000 • 155 citations

Differential expression and alternative splicing of TRP channel genes in smooth muscles

2001 • 141 citations

Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression

2000 • 138 citations

Calcium signalling

1999 • 136 citations

Regulation of Drosophila transient receptor potential‐like (TrpL) channels by phospholipase C‐dependent mechanisms

2001 • 135 citations

Normal Phototransduction in Drosophila Photoreceptors Lacking an InsP3 Receptor Gene

2000 • 132 citations

Phospholipase C-δ1 Is Activated by Capacitative Calcium Entry That Follows Phospholipase C-β Activation upon Bradykinin Stimulation

1999 • 131 citations

Chromosomal Localization and Genomic Characterization of the Mouse Melastatin Gene (Mlsn1)

1998 • 104 citations

Patterns of melastatin mRNA expression in melanocytic tumors

2000 • 89 citations

Expression and Up-Regulation of Alternatively Spliced Transcripts of Melastatin, a Melanoma Metastasis-Related Gene, in Human Melanoma Cells

2000 • 87 citations

Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2

2000 • 86 citations

12 Store-operated calcium channels

1999 • 85 citations

Differential distribution of TRP Ca2+ channel isoforms in mouse brain.

1998 • 74 citations

When Do Epileptic Seizures Really Begin?

2001 • 68 citations

[Novel type of signaling molecules: protein kinases covalently linked to ion channels].

2001 • 59 citations

A Calcium-activated Cation Current by an Alternatively Spliced Form of Trp3 in the Heart

2000 • 56 citations

Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2

2000 • 50 citations

Mtr1, a Novel Biallelically Expressed Gene in the Center of the Mouse Distal Chromosome 7 Imprinting Cluster, is a Member of the Trp Gene Family

2000 • 49 citations