Zn2+ transporters and Zn2+ homeostasis in neurons

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis

2001 • 1,430 citations

A novel iron-regulated metal transporter from plants identified by functional expression in yeast.

1996 • 1,353 citations

Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine

2000 • 1,112 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors

2003 • 1,073 citations

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

1998 • 946 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.

1995 • 746 citations

ZnT-3, a putative transporter of zinc into synaptic vesicles

1996 • 712 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

The elusive function of metallothioneins

1998 • 676 citations

Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypognadism.

1963 • 582 citations

The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation.

1996 • 544 citations

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT 3 gene

1999 • 534 citations

Eukaryotic zinc transporters and their regulation.

2001 • 513 citations

A Novel Member of a Zinc Transporter Family Is Defective in Acrodermatitis Enteropathica

2002 • 485 citations

The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses

2000 • 477 citations

Altered selectivity in anArabidopsismetal transporter

2000 • 454 citations

ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.

1996 • 447 citations

Movement of zinc and its functional significance in the brain

2000 • 415 citations

Preferential Zn ²⁺ influx through Ca ²⁺ -permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

1999 • 408 citations

Modulation of mitochondrial function by endogenous Zn ²⁺ pools

2003 • 403 citations

The Transcription Factor MTF-1 Mediates Metal Regulation of the Mouse ZnT1 Gene

2000 • 396 citations

Inhibitory sites in enzymes: Zinc removal and reactivation by thionein

1999 • 387 citations

Induction of Neuronal Apoptosis by Thiol Oxidation

2000 • 376 citations

Synaptically released zinc: physiological functions and pathological effects.

2001 • 362 citations

A novel gene involved in zinc transport is deficient in the lethal milk mouse

1997 • 359 citations

Zinc-Induced Cortical Neuronal Death: Contribution of Energy Failure Attributable to Loss of NAD⁺and Inhibition of Glycolysis

2000 • 354 citations

Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey

1997 • 352 citations

Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat

1983 • 351 citations

Translocation of zinc may contribute to seizure-induced death of neurons

1989 • 347 citations

Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration

2003 • 346 citations

Cellular zinc sensors: MTF-1 regulation of gene expression.

2001 • 323 citations

Functional Expression of the Human hZIP2 Zinc Transporter

2000 • 322 citations

Regulation of the zinc transporter ZnT-1 by dietary zinc

1998 • 306 citations

The Human ZIP1 Transporter Mediates Zinc Uptake in Human K562 Erythroleukemia Cells

2001 • 293 citations

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

2000 • 283 citations

Induction of Mossy Fiber→CA3 Long-Term Potentiation Requires Translocation of Synaptically Released Zn²⁺

2001 • 276 citations

Zn2+ Induces Permeability Transition Pore Opening and Release of Pro-apoptotic Peptides from Neuronal Mitochondria

2001 • 269 citations

ZnT7, a Novel Mammalian Zinc Transporter, Accumulates Zinc in the Golgi Apparatus

2003 • 267 citations

Nramp2 Expression Is Associated with pH-dependent Iron Uptake across the Apical Membrane of Human Intestinal Caco-2 Cells

2000 • 263 citations

Zap1p, a Metalloregulatory Protein Involved in Zinc-Responsive Transcriptional Regulation in Saccharomyces cerevisiae

1997 • 261 citations

Rapid Translocation of Zn²⁺From Presynaptic Terminals Into Postsynaptic Hippocampal Neurons After Physiological Stimulation

2001 • 260 citations

Meeting of the minds: Metalloneurochemistry

2003 • 259 citations

Cloning and Characterization of a Novel Mammalian Zinc Transporter, Zinc Transporter 5, Abundantly Expressed in Pancreatic β Cells

2002 • 254 citations

The LZT proteins; the LIV-1 subfamily of zinc transporters

2003 • 252 citations

Zinc metallothionein imported into liver mitochondria modulates respiration

2001 • 250 citations

Disruption of the Metallothionein-III Gene in Mice: Analysis of Brain Zinc, Behavior, and Neuron Vulnerability to Metals, Aging, and Seizures

1997 • 248 citations

Zinc-mediated inhibition of GABAA receptors: discrete binding sites underlie subtype specificity

2003 • 246 citations

A zinc-sensing receptor triggers the release of intracellular Ca ²⁺ and regulates ion transport

2001 • 239 citations

Differential Regulation of Zinc Transporter 1, 2, and 4 mRNA Expression by Dietary Zinc in Rats

2001 • 239 citations

Mossy fiber Zn2+ spillover modulates heterosynapticN-methyl-<scp>d</scp>-aspartate receptor activity in hippocampal CA3 circuits

2002 • 235 citations

Seizures and neuronal damage in mice lacking vesicular zinc

2000 • 235 citations

Accumulation of Zinc in Degenerating Hippocampal Neurons of ZnT3-Null Mice after Seizures: Evidence against Synaptic Vesicle Origin

2000 • 227 citations

Mammalian Zinc Transporters ,

1998 • 226 citations

Evidence for a Zinc Uptake Transporter in Human Prostate Cancer Cells Which Is Regulated by Prolactin and Testosterone

1999 • 224 citations

Selective release of endogenous zinc from the hippocampal mossy fibers in situ

1987 • 220 citations

Functional Characterization of a Novel Mammalian Zinc Transporter, ZnT6

2002 • 212 citations

Cellular Zinc and Redox States Converge in the Metallothionein/Thionein Pair

2003 • 200 citations

Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study

1988 • 175 citations

Zinc Release from Protein Kinase C as the Common Event during Activation by Lipid Second Messenger or Reactive Oxygen

2002 • 172 citations

Imaging free zinc in synaptic terminals in live hippocampal slices

1997 • 167 citations

The Role of NADPH Oxidase and Neuronal Nitric Oxide Synthase in Zinc-Induced Poly(ADP-ribose) Polymerase Activation and Cell Death in Cortical Culture

2002 • 163 citations

AMPA/kainate receptor‐triggered Zn²⁺ entry into cortical neurons induces mitochondrial Zn²⁺ uptake and persistent mitochondrial dysfunction

2000 • 156 citations

Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ

1985 • 154 citations

Measurement of Intracellular Free Zinc Concentrations Accompanying Zinc-Induced Neuronal Death

1999 • 151 citations

Blockade of Ca²⁺-Permeable AMPA/Kainate Channels Decreases Oxygen–Glucose Deprivation-Induced Zn²⁺Accumulation and Neuronal Loss in Hippocampal Pyramidal Neurons

2002 • 150 citations

A Novel Zinc-regulated Human Zinc Transporter, hZTL1, Is Localized to the Enterocyte Apical Membrane

2002 • 147 citations

Expression of Zinc Transporter Gene, ZnT-1, Is Induced after Transient Forebrain Ischemia in the Gerbil

1997 • 140 citations

Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse

2001 • 138 citations

Metals and Oxidative Damage in Neurological Disorders

1997 • 126 citations

Metallothionein Expression Is Increased in Monocytes and Erythrocytes of Young Men during Zinc Supplementation , ,

1998 • 117 citations

Fluorescent zinc indicators for neurobiology

2002 • 117 citations

Zn²⁺ currents are mediated by calcium‐permeable AMPA/Kainate channels in cultured murine hippocampal neurones

2002 • 117 citations

Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya

1998 • 116 citations

Susceptibility to kainate‐induced seizures under dietary zinc deficiency

2003 • 110 citations

Regulation of Zinc Metabolism and Genomic Outcomes

2003 • 106 citations

L-type Ca2+ channel-mediated Zn2+ toxicity and modulation by ZnT-1 in PC12 cells11Published on the World Wide Web on 12 October 2000.

2000 • 106 citations

Zn²⁺ current is mediated by voltage‐gated Ca²⁺ channels and enhanced by extracellular acidity in mouse cortical neurones

2000 • 102 citations

Properties of the mammalian and yeast metal-ion transporters DCT1 and Smf1p expressed in Xenopus laevis oocytes

2001 • 102 citations

A Reevaluation of Neuronal Zinc Measurements: Artifacts Associated with High Intracellular Dye Concentration

2002 • 102 citations

Metallothionein Knockout and Transgenic Mice Exhibit Altered Intestinal Processing of Zinc with Uniform Zinc-Dependent Zinc Transporter-1 Expression ,

1998 • 101 citations

Distribution of the zinc transporter ZnT‐1 in comparison with chelatable zinc in the mouse brain

2002 • 98 citations

Mitochondrial Sequestration and Ca2+-Dependent Release of Cytosolic Zn2+ Loads in Cortical Neurons

2002 • 86 citations

Zinc Transporters in the Rat Mammary Gland Respond to Marginal Zinc and Vitamin A Intakes during Lactation

2002 • 84 citations

Intracellular zinc distribution and transport in C6 rat glioma cells

2002 • 84 citations

Zinc as an Inducer of the Membrane Permeability Transition in Rat Liver Mitochondria

1999 • 83 citations

Severe Zinc Deficiency: Effects on the Distribution of Nine Elements (Potassium, Phosphorus, Sodium, Magnesium, Calcium, Iron, Zinc, Copper and Manganese) in Regions of the Rat Brain

1983 • 82 citations

Depletion of Intracellular Zinc from Neurons by Use of an Extracellular Chelator In Vivo and In Vitro

2002 • 81 citations

Is Zn²⁺ transported by the mitochondrial calcium uniporter?

1994 • 73 citations

Nitric oxide causes apparent release of zinc from presynaptic boutons

2002 • 72 citations

Routes of zinc entry in mouse cortical neurons: role in zinc‐induced neurotoxicity

2000 • 71 citations

Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells

2002 • 70 citations

Fluorescent Detection of Zn2+-Rich Vesicles with Zinquin: Mechanism of Action in Lipid Environments

2001 • 69 citations

Measurement of Intracellular Free Zinc in Living Neurons

1997 • 67 citations

Ion Transport by Heart Mitochondria. X. The Uptake and Release of Zn²⁺ and Its Relation to the Energy-Linked Accumulation of Magnesium^*

1967 • 58 citations

Differential subcellular localization of hZip1 in adherent and non‐adherent cells

2001 • 57 citations

A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus.

2001 • 53 citations

Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine

2001 • 52 citations

Zinc-enriched (ZEN) terminals in mouse spinal cord: immunohistochemistry and autometallography

2000 • 52 citations

Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice

2003 • 51 citations

pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons

2002 • 50 citations

Developmental Expression of ZnT3 in Mouse Brain: Correlation between the Vesicular Zinc Transporter Protein and Chelatable Vesicular Zinc (CVZ) Cells. Glial and Neuronal CVZ Cells Interact

2002 • 48 citations

Depolarization-Induced 65Zinc Influx into Cultured Cortical Neurons

2002 • 38 citations

The Role of Zinc in Brain and Nerve Functions

1997 • 35 citations

Evidence for a zinc/proton antiporter in rat brain

2000 • 33 citations

Zinc-rich synaptic boutons in human temporal cortex biopsies

2000 • 33 citations

Imaging synaptic zinc release in living nervous tissue

2001 • 31 citations

A Light and Electron Microscopic Study of Divalent Metal Transporter-1 Distribution in the Rat Hippocampus, after Kainate-Induced Neuronal Injury

2002 • 29 citations

Zinc Status Influences Zinc Transport by Porcine Brain Capillary Endothelial Cells

2002 • 29 citations

Localization of zinc-enriched neurons in the mouse peripheral sympathetic system

2002 • 27 citations

Neurobiology of Zinc

1989 • 24 citations

Pre-treatment of Caco-2 cells with zinc during the differentiation phase alters the kinetics of zinc uptake and transport22&gt; Presented in part at Experimental Biology 99, April 1999, [Reeves, P.G. &amp; Briske-Anderson, M. (1999) Physiological changes in zinc concentrations of Caco-2 cells alter the uptake and transport kinetics of zinc. FASEB J. 13:A568, 1999 (abs)].

2001 • 21 citations

The influence of zinc status on the kinetics of zinc uptake into cultured endothelial cells

1999 • 15 citations