Spatial and Temporal Dynamics of T Cell Receptor Signaling with a Photoactivatable Agonist

Cell Signaling by Receptor Tyrosine Kinases

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Cell Signaling by Receptor Tyrosine Kinases

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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

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Three-dimensional segregation of supramolecular activation clusters in T cells

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T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

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LAT

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HOW TCRS BIND MHCS, PEPTIDES, AND CORECEPTORS

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T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

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CTLA-4: new insights into its biological function and use in tumor immunotherapy

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LIGAND RECOGNITION BY αβ T CELL RECEPTORS

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Signals and signs for lymphocyte responses

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Direct observation of ligand recognition by T cells

2002 • 802 citations

Single-Molecule Microscopy Reveals Plasma Membrane Microdomains Created by Protein-Protein Networks that Exclude or Trap Signaling Molecules in T Cells

2005 • 748 citations

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76

2005 • 685 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

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Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

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Selective modulation of protein kinase C-Θ during T-cell activation

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Controlling Cell Chemistry with Caged Compounds

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Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses

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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

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Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

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T cells use two directionally distinct pathways for cytokine secretion

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Continuous T cell receptor signaling required for synapse maintenance and full effector potential

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Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton

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Properties and Uses of Photoreactive Caged Compounds

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Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

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The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

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High- and Low-Potency Ligands with Similar Affinities for the TCR

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Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

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Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation

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CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

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Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells.

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Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

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Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal

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Maintenance and modulation of T cell polarity

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Immunological Synapses Are Versatile Structures Enabling Selective T Cell Polarization

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Role of Diacylglycerol Kinase α in the Attenuation of Receptor Signaling

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Control of astrocyte Ca2+ oscillations and waves by oscillating translocation and activation of protein kinase C

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Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas.

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Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

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Dynamics of Cell Surface Molecules During T Cell Recognition

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Diacylglycerol and Protein Kinase D Localization during T Lymphocyte Activation

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CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

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The lifetime of inositol 1,4,5-trisphosphate in single cells.

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Regulation of T Cell Receptor-induced Activation of the Ras-ERK Pathway by Diacylglycerol Kinase ζ

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Mapping the sensitivity of T cells with an optical trap: Polarity and minimal number of receptors for Ca²⁺signaling

1999 • 109 citations

Linker for Activation of T Cells, ζ-Associated Protein-70, and Src Homology 2 Domain-Containing Leukocyte Protein-76 are Required for TCR-Induced Microtubule-Organizing Center Polarization

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LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways

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The Tumor Suppressor PTEN Regulates T Cell Survival and Antigen Receptor Signaling by Acting as a Phosphatidylinositol 3-Phosphatase

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Local Photorelease of Caged Thymosin β4 in Locomoting Keratocytes Causes Cell Turning

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CD4 Raft Association and Signaling Regulate Molecular Clustering at the Immunological Synapse Site

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Cooperative enhancement of specificity in a lattice of T cell receptors

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A Ligation and Photorelease Strategy for the Temporal and Spatial Control of Protein Function in Living Cells

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Biphasic increase in intracellular calcium induced by platelet‐activating factor in macrophages

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Feedback control of T–cell receptor activation

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Differential Requirements for CD4 in TCR-Ligand Interactions

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Control of Antigen Presentation with a Photoreleasable Agonist Peptide

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Dependence of T cell activation on area of contact and density of a ligand-coated surface

2000 • 11 citations