Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

2000 • 3,739 citations

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

2003 • 1,415 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor

2002 • 972 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Protein–protein interactions define specificity in signal transduction

2000 • 757 citations

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

2002 • 597 citations

Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins

2002 • 565 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

Trafficking of the ErbB receptors and its influence on signaling

2003 • 344 citations

Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless

2004 • 291 citations

ITC in the post-genomic era…? Priceless

2004 • 210 citations

Crystal Structure of the Mammalian Grb2 Adaptor

1995 • 202 citations

G Protein–Coupled Receptor Oligomerization

2004 • 193 citations

High resolution mapping of mast cell membranes reveals primary and secondary domains of FcϵRI and LAT

2001 • 177 citations

Sedimentation Velocity Analysis of Heterogeneous Protein-Protein Interactions: Lamm Equation Modeling and Sedimentation Coefficient Distributions c(s)

2005 • 169 citations

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

2005 • 166 citations

Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy

1999 • 144 citations

Lipid raft domains and protein networks in T-cell receptor signal transduction

2004 • 142 citations

Role of Grb2 in EGF-stimulated EGFR internalization

2002 • 140 citations

Studying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation

2004 • 134 citations

Internalization of the epidermal growth factor receptor: role in signalling

2001 • 116 citations

LAT regulates γδ T cell homeostasis and differentiation

2003 • 113 citations

Binding Specificity of Multiprotein Signaling Complexes Is Determined by Both Cooperative Interactions and Affinity Preferences

2004 • 108 citations

Minimal Requirement of Tyrosine Residues of Linker for Activation of T Cells in TCR Signaling and Thymocyte Development

2003 • 107 citations

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

1994 • 104 citations

Boundary Problems in the Sedimentation and Electrophoresis of Complex Systems in Rapid Reversible Equilibrium

1956 • 88 citations

Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activation

2003 • 77 citations

Molecular mechanisms of cytokine receptor activation

2002 • 76 citations

In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.

1994 • 75 citations

The Grb2-mSos1 Complex Binds Phosphopeptides with Higher Affinity than Grb2

1996 • 75 citations

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.

1994 • 75 citations

High-Resolution Multicolor Imaging of Dynamic Signaling Complexes in T Cells Stimulated by Planar Substrates

2003 • 70 citations

The role of Grb2-associated proteins in T-cell activation

1997 • 68 citations

Solution structure of Grb2 reveals extensive flexibility necessary for target recognition

2001 • 67 citations

Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity.

1995 • 51 citations

14-3-3 Facilitates Insulin-Stimulated Intracellular Trafficking of Insulin Receptor Substrate 1

2002 • 50 citations

Design of Peptoid Analogue Dimers and Measure of Their Affinity for Grb2 SH3 Domains

2004 • 30 citations