The Tumor Suppressor PTEN Regulates T Cell Survival and Antigen Receptor Signaling by Acting as a Phosphatidylinositol 3-Phosphatase

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

1997 • 883 citations

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1997 • 778 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1999 • 572 citations

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

1997 • 464 citations

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

1997 • 437 citations

Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas.

1997 • 259 citations

Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy?

1994 • 109 citations

Allelotype analysis of childhood acute lymphoblastic leukemia.

1995 • 92 citations

Regulation of the Lck SH2 Domain by Tyrosine Phosphorylation

1996 • 86 citations

Alterations of the MMAC1/PTEN Gene in Lymphoid Malignancies

1998 • 77 citations

Inhibition of Phosphatidylinositol 3‐Kinase Blocks T Cell Antigen Receptor/CD3‐Induced Activation of the Mitogen‐Activated Kinase Erk2

1996 • 72 citations

Novel polyphosphoinositides in cell growth and activation.

1991 • 61 citations

Recurrent abnormalities of chromosome bands 10q23–25 in non‐Hodgkin's lymphoma

1992 • 59 citations

Reconstitution of T Cell Antigen Receptor‐Induced Erk2 Kinase Activation in Lck‐Negative JCaM1 Cells by Syk

1997 • 47 citations

Identification of the Site in the Syk Protein Tyrosine Kinase That Binds the SH2 Domain of Lck

1996 • 44 citations

Cancer predisposition: Where's the phosphate?

1998 • 15 citations