Dependence of T cell activation on area of contact and density of a ligand-coated surface

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Handbook of chemistry and physics

1930 • 11,993 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Handbook of chemistry and physics

1961 • 2,593 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion

1991 • 532 citations

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.

1995 • 528 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

Molecular model for receptor-stimulated calcium spiking.

1988 • 416 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Identification of the components of the murine T cell antigen receptor complex

1985 • 333 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

1998 • 275 citations

The Three-Dimensional Structure at 6 A Resolution of a Human γG1 Immunoglobulin Molecule

1971 • 249 citations

Intracellular calcium dependence of gene expression in single T lymphocytes.

1994 • 244 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal

1997 • 194 citations

Monoclonal antibodies that inhibit IgE binding.

1986 • 113 citations

Cross-linking of receptor-bound IgE to aggregates larger than dimers leads to rapid immobilization.

1986 • 112 citations

Imaging early steps of human T cell activation by antigen-presenting cells.

1992 • 108 citations

Cross-linking of immunoglobulin E-receptor complexes induces their interaction with the cytoskeleton of rat basophilic leukemia cells.

1986 • 75 citations

Surface-Density and Orientation Effects on Immobilized Antibodies and Antibody Fragments

1993 • 74 citations

TCR-mediated adhesion of T cell hybridomas to planar bilayers containing purified MHC class II/peptide complexes and receptor shedding during detachment.

1996 • 46 citations

T cell receptor aggregation, but not dimerization, induces increased cytosolic calcium concentrations and reveals a lack of stable association between CD4 and the T cell receptor.

1992 • 42 citations

Ca²⁺ mobilization in physiologically stimulated single T cells gradually increases with peptide concentration (analog signaling)

1994 • 34 citations

Regulation of CD3-induced phospholipase C-gamma 1 (PLC gamma 1) tyrosine phosphorylation by CD4 and CD45 receptors.

1992 • 33 citations

Controlled Cell Deformation Produces Defined Areas of Contact between Cells and Ligand-Coated Surfaces

2001 • 24 citations

Calcium response of helper T lymphocytes to antigen-presenting cells in a single-cell assay

1995 • 20 citations

Controlling receptor-ligand contact to examine kinetics of T cell activation

1997 • 5 citations

Controlling receptor-ligand contact to examine kinetics of T cell activation

1997 • 5 citations