Diacylglycerol and Protein Kinase D Localization during T Lymphocyte Activation

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

The Immunological Synapse

2001 • 987 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5

2004 • 512 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

Protein Kinase D Signaling

2005 • 426 citations

Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

2003 • 400 citations

T cell antigen receptor signal transduction

1997 • 390 citations

Synaptic pattern formation during cellular recognition

2001 • 346 citations

Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells

1998 • 331 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Protein kinase C and beyond

2004 • 300 citations

Tuning immune responses: diversity and adaptation of the immunological synapse

2005 • 294 citations

What is the importance of the immunological synapse?

2004 • 282 citations

Emerging and diverse roles of protein kinase C in immune cell signalling

2003 • 248 citations

Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network

2004 • 244 citations

T cell antigen-receptor signal transduction

1999 • 240 citations

Novel “Nonkinase” Phorbol Ester Receptors: The C1 Domain Connection

2002 • 224 citations

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

2002 • 212 citations

Enhanced T cell responses due to diacylglycerol kinase ζ deficiency

2003 • 208 citations

Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions

1997 • 200 citations

Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor–induced Nur77 expression and apoptosis

2005 • 167 citations

Dynamics of p56lck Translocation to the T Cell Immunological Synapse following Agonist and Antagonist Stimulation

2002 • 166 citations

Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain

2001 • 166 citations

Protein Kinase D-Mediated Anterograde Membrane Trafficking Is Required for Fibroblast Motility

2004 • 163 citations

Imaging antigen-induced PI3K activation in T cells

2002 • 159 citations

Essential Role for Protein Kinase D Family Kinases in the Regulation of Class II Histone Deacetylases in B Lymphocytes

2006 • 144 citations

Diacylglycerol-dependent Binding Recruits PKCθ and RasGRP1 C1 Domains to Specific Subcellular Localizations in Living T Lymphocytes

2004 • 138 citations

Protein Kinase D1 Phosphorylates HDAC7 and Induces Its Nuclear Export after T-cell Receptor Activation

2004 • 136 citations

Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K– and Vav-dependent pathway, but does not absolutely require phospholipase C

2002 • 131 citations

Spatial and temporal regulation of protein kinase D (PKD)

2000 • 123 citations

Protein Kinase D

2000 • 116 citations

Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C

2001 • 108 citations

Rapid Protein Kinase D Translocation in Response to G Protein-coupled Receptor Activation

2001 • 106 citations

Protein kinase C mu is located at the Golgi compartment.

1996 • 105 citations

T Cell Activation In Vivo Targets Diacylglycerol Kinase α to the Membrane: A Novel Mechanism for Ras Attenuation

2003 • 99 citations

Intracellular Location and Cell Context-Dependent Function of Protein Kinase D

2003 • 91 citations

Regulated Nucleocytoplasmic Transport of Protein Kinase D in Response to G Protein-coupled Receptor Activation

2001 • 91 citations

Imaging immune cell interactions and functions: SMACs and the Immunological Synapse

2003 • 90 citations

Protein Kinase D1 and the β1 Integrin Cytoplasmic Domain Control β1 Integrin Function via Regulation of Rap1 Activation

2005 • 87 citations

Protein Kinase Cν/Protein Kinase D3 Nuclear Localization, Catalytic Activation, and Intracellular Redistribution in Response to G Protein-coupled Receptor Agonists

2003 • 84 citations

Dynamic re‐distribution of protein kinase D (PKD) as revealed by a GFP‐PKD fusion protein: dissociation from PKD activation

1999 • 72 citations

Dissimilar phorbol ester binding properties of the individual cysteine‐rich motifs of protein kinase D

1998 • 62 citations

Activation of Hematopoietic Progenitor Kinase 1 Involves Relocation, Autophosphorylation, and Transphosphorylation by Protein Kinase D1

2005 • 60 citations

Mechanism of Persistent Protein Kinase D1 Translocation and Activation

2003 • 57 citations

Membrane Translocation of Protein Kinase Cθ during T Lymphocyte Activation Requires Phospholipase C-γ-generated Diacylglycerol

2003 • 34 citations

Protein Kinase D Interacts with Golgi via Its Cysteine-Rich Domain

2001 • 30 citations

Interleukin-2 Causes an Increase in Saturated/Monounsaturated Phosphatidic Acid Derived from 1,2-Diacylglycerol and 1-O-Alkyl-2-acylglycerol

1999 • 28 citations

Dual Phospholipase C/Diacylglycerol Requirement for Protein Kinase D1 Activation in Lymphocytes

2004 • 28 citations