T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Rab11 regulates recycling through the pericentriolar recycling endosome.

1996 • 1,293 citations

LAT

1998 • 1,251 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LAT Palmitoylation

1998 • 837 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

EEA1, an Early Endosome-Associated Protein.

1995 • 706 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins

2002 • 565 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

Multicolour imaging of post-Golgi sorting and trafficking in live cells

2001 • 419 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

The Vesicle Docking Protein p115 Binds GM130, a cis-Golgi Matrix Protein, in a Mitotically Regulated Manner

1997 • 408 citations

Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading

2001 • 404 citations

Making the T Cell Receptor Go the Distance: A Topological View of T Cell Activation

1997 • 399 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

1998 • 336 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1999 • 325 citations

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

2000 • 295 citations

Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton

2000 • 294 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

2001 • 270 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1999 • 252 citations

ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse

2001 • 247 citations

Interactions between FcεRI and lipid raft components are regulated by the actin cytoskeleton

2000 • 225 citations

Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT

2001 • 194 citations

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

2000 • 194 citations

The ubiquitin-proteasome system and endocytosis

1999 • 188 citations

Dynamics of the immunological synapse: finding, establishing and solidifying a connection

2002 • 184 citations

High resolution mapping of mast cell membranes reveals primary and secondary domains of FcϵRI and LAT

2001 • 177 citations

Distinct Patterns of Membrane Microdomain Partitioning in Th1 and Th2 Cells

2001 • 157 citations

Selective Accumulation of Raft-Associated Membrane Protein Lat in T Cell Receptor Signaling Assemblies

2000 • 154 citations

Imaging Synapse Formation during Thymocyte Selection

2002 • 142 citations

Information transfer at the immunological synapse

2000 • 141 citations

Role of Grb2 in EGF-stimulated EGFR internalization

2002 • 140 citations

Positive and negative regulation of t-cell activation by adaptor proteins

2001 • 137 citations

Inhibition of T Cell Receptor-Coreceptor Interactions by Antagonist Ligands Visualized by Live FRET Imaging of the T-Hybridoma Immunological Synapse

2002 • 132 citations

Cutting Edge: TCR Signaling Induces Selective Exclusion of CD43 from the T Cell-Antigen-Presenting Cell Contact Site

1998 • 123 citations

Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

1998 • 121 citations

Distinct compartmentalization of TGN46 and beta 1,4-galactosyltransferase in HeLa cells.

1997 • 116 citations

Characterization of ochratoxin A transport by human organic anion transporters

2001 • 111 citations

Mechanisms of signaling by the hematopoietic-specific adaptor proteins, slp-76 and lat and their b cell counterpart, blnk/slp-65

2001 • 70 citations

ZAP-70 Association with T Cell Receptor ζ (TCRζ): Fluorescence Imaging of Dynamic Changes upon Cellular Stimulation

1998 • 64 citations