Kinetic proofreading in T-cell receptor signal transduction.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

1974 • 1,532 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Kinetic amplification of enzyme discrimination

1975 • 742 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation

1990 • 410 citations

T Cell Selection in the Thymus

1988 • 405 citations

Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors

1991 • 366 citations

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

1993 • 271 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.

1993 • 238 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Antigen Analogs/MHC Complexes as Specific T Cell Receptor Antagonists

1994 • 195 citations

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.

1993 • 177 citations

Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.

1993 • 176 citations

Functional consequences of engagement of the T cell receptor by low affinity ligands.

1993 • 171 citations

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.

1994 • 159 citations

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

1993 • 154 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

The level of CD8 expression can determine the outcome of thymic selection

1992 • 134 citations

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.

1992 • 119 citations

Beat the clock: paradigms for NTPases in the maintenance of biological fidelity

1993 • 86 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

Cross-linking and Conformational Change in T-cell Receptors: Role in Activation and in Repertoire Selection

1989 • 79 citations

Interactions Between SH2 Domains and Tyrosine-Phosphorylated Platelet-Derived Growth Factor β-receptor Sequences: Analysis of Kinetic Parameters by a Novel Biosensor-Based Approach

1993 • 31 citations

SH2 Domains Exhibit High-Affinity Binding to Tyrosine-Phosphorylated Peptides Yet Also Exhibit Rapid Dissociation and Exchange

1993 • 30 citations