Bistability in the JNK cascade

Construction of a genetic toggle switch in Escherichia coli

2000 • 4,184 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Emergent Properties of Networks of Biological Signaling Pathways

1999 • 1,696 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Ultrasensitivity in the mitogen-activated protein kinase cascade.

1996 • 1,200 citations

General Conclusions: Teleonomic Mechanisms in Cellular Metabolism, Growth, and Differentiation

1961 • 1,043 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion

2001 • 706 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

1995 • 658 citations

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

1996 • 589 citations

Regulation and function of the JNK subgroup of MAP kinases

1997 • 484 citations

Amplification and Adaptation in Regulatory and Sensory Systems

1982 • 464 citations

Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos

1993 • 438 citations

Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible

2001 • 362 citations

Cell cycle regulation of a Xenopus Wee1-like kinase.

1995 • 316 citations

Multistability: a major means of differentiation and evolution in biological systems

1999 • 289 citations

1. Signal transduction by the c-Jun N-terminal kinase

1999 • 264 citations

Interconvertible Enzyme Cascades in Cellular Regulation

1980 • 257 citations

Frequency selectivity, multistability, and oscillations emerge from models of genetic regulatory systems

1998 • 183 citations

Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade

1995 • 172 citations

Positive Feedback between MAP Kinase and Mos duringXenopusOocyte Maturation

1996 • 103 citations

Mos proto-oncogene function during oocyte maturation in Xenopus.

1996 • 97 citations

The stress activated protein kinase pathway.

1996 • 90 citations

The Mitogen-Activated Protein Kinase Signaling Pathway Stimulates Mos mRNA Cytoplasmic Polyadenylation during Xenopus Oocyte Maturation

1999 • 86 citations

Bistable biochemical switching and the control of the events of the cell cycle*

1997 • 69 citations

A model for a bistable biochemical trigger of mitosis

1996 • 68 citations

c-Jun N-terminal Kinase Activation in Xenopus laevis Eggs and Embryos

2001 • 58 citations

Bistability and irreversible transitions in a simple substrate cycle

1987 • 45 citations

Bistability without Hysteresis in Chemical Reaction Systems: A Theoretical Analysis of Irreversible Transitions between Multiple Steady States

1997 • 37 citations

Multiple attractors in immunology: theory and experiment

1998 • 22 citations