A critical role of neural-specific JNK3 for ischemic apoptosis

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Endovascular Stroke Therapy Results Improve over Time: The ‘Learning Curve' at a New Comprehensive Stoke Center

2015 • 2,520 citations

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

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Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

Anoxic-ischemic encephalopathy in rats.

1960 • 644 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

2001 • 568 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

1999 • 472 citations

Programmed Cell Death in Cerebral Ischemia

2001 • 471 citations

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

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Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

1998 • 454 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage

2000 • 421 citations

Multiple Molecular Penumbras after Focal Cerebral Ischemia

2000 • 398 citations

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1998 • 366 citations

Role of Mitogen- and Stress-Activated Kinases in Ischemic Injury

2002 • 363 citations

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

1999 • 357 citations

Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury

1998 • 330 citations

Microglia and Macrophages Are the Major Source of Tumor Necrosis Factor in Permanent Middle Cerebral Artery Occlusion in Mice

2000 • 310 citations

Activation of Mitogen-Activated Protein Kinases after Transient Forebrain Ischemia in Gerbil Hippocampus

2000 • 252 citations

Strain-Related Differences in Susceptibility to Transient Forebrain Ischemia in SV-129 and C57Black/6 Mice

1997 • 249 citations

Specific Caspase Pathways Are Activated in the Two Stages of Cerebral Infarction

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Requirement of the JIP1 scaffold protein for stress-induced JNK activation

2001 • 230 citations

c-Jun N-Terminal Protein Kinase (JNK) 2/3 Is Specifically Activated by Stress, Mediating c-Jun Activation, in the Presence of Constitutive JNK1 Activity in Cerebellar Neurons

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Developmental expression in the mouse nervous system of the p493F12 SAP kinase

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Fas Receptor and Neuronal Cell Death after Spinal Cord Ischemia

2000 • 127 citations

Reprogramming the signalling requirement for AP‐1 (activator protein‐1) activation during differentiation of precursor CD4⁺ T‐cells into effector Th1 and Th2 cells

1997 • 115 citations

Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli

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Caspase-Activated DNase/DNA Fragmentation Factor 40 Mediates Apoptotic DNA Fragmentation in Transient Cerebral Ischemia and in Neuronal Cultures

2001 • 106 citations

Evidence for Activation of Caspase‐3‐Like Protease in Excitotoxin‐ and Hypoxia/Hypoglycemia‐Injured Neurons

1998 • 96 citations

Alloantigen presenting capacity, T cell alloreactivity and NK function of G-CSF-mobilized peripheral blood cells

1998 • 93 citations

Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization

1995 • 75 citations

Inflammatory Response and Glutathione Peroxidase in a Model of Stroke

2002 • 62 citations

The ischaemic penumbra

2001 • 60 citations

Pharmacological interventions for stroke: failures and future

2002 • 60 citations

Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia

1999 • 52 citations