MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Studies on the transformation of intact yeast cells by the LiAc/SS‐DNA/PEG procedure

1995 • 2,001 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

α-Actinin: Immunofluorescent localization of a muscle structural protein in nonmuscle cells

1975 • 599 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Signaling through focal adhesion kinase

1997 • 468 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption

1998 • 322 citations

Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function

1992 • 320 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)

1996 • 309 citations

Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin.

1992 • 309 citations

Requirement of CDC42 for Salmonella -Induced Cytoskeletal and Nuclear Responses

1996 • 303 citations

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

1997 • 300 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain.

1993 • 267 citations

HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

1998 • 260 citations

α-Actinin, a New Structural Protein from Striated Muscle

1965 • 252 citations

Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18.

1995 • 252 citations

Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein

1996 • 248 citations

MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis

1998 • 236 citations

JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?

1998 • 217 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

MEK Kinase Is Involved in Tumor Necrosis Factor α-Induced NF-κB Activation and Degradation of IκB-α

1996 • 197 citations

[27] Gene identification using the yeast two-hybrid system

1996 • 195 citations

Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

1998 • 193 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase.

1994 • 186 citations

Cytoskeletal Reorganization by G Protein-Coupled Receptors Is Dependent on Phosphoinositide 3-Kinase γ, a Rac Guanosine Exchange Factor, and Rac

1998 • 181 citations

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

1994 • 171 citations

Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-α Activation of SAPK in Melanoma Cells

1997 • 169 citations

Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation

1996 • 166 citations

Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of alpha-actinin.

1991 • 165 citations

Activation of Protein Kinase Cascades by Osmotic Shock

1995 • 154 citations

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

1995 • 144 citations

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain.

1996 • 134 citations

Electron microscopic study of α-actinin

1975 • 131 citations

Actin crosslinking proteins at the leading edge

1994 • 128 citations

Selection of Dictyostelium mutants defective in cytoskeletal proteins: use of an antibody that binds to the ends of alpha-actinin rods.

1986 • 128 citations

Identification of a Phosphatidylinositol 4,5-Bisphosphate-binding Site in Chicken Skeletal Muscle α-Actinin

1996 • 123 citations

Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1

1998 • 122 citations

Physical and Functional Interaction of Rabphilin-3A with α-Actinin

1996 • 115 citations

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases

1997 • 111 citations

Specificity of LIM Domain Interactions with Receptor Tyrosine Kinases

1996 • 108 citations

An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators

1997 • 102 citations

Ring finger motif of Arabidopsis thaliana COP1 defines a new class of zinc-binding domain.

1993 • 97 citations

ERK3 Is a Constitutively Nuclear Protein Kinase

1996 • 92 citations

Stress-activated protein kinases are negatively regulated by cell density

1998 • 92 citations

Phosphatidylinositol 3-kinase binds to α-actinin through the p85 subunit

1994 • 92 citations

Substructure and higher structure of chicken smooth muscle alpha-actinin molecule.

1988 • 88 citations

Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1

1997 • 71 citations

Binding of the Cytoplasmic Domain of Intercellular Adhesion Molecule-2 (ICAM-2) to α-Actinin

1996 • 68 citations

Further characterization of the alpha-actinin-actin interface and comparison with filamin-binding sites on actin.

1993 • 55 citations

The Rho GTPase regulates protein kinase activity

1996 • 19 citations