Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Mikroskopische Technik

1948 • 2,349 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

1997 • 1,294 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 • 743 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

2002 • 633 citations

Lineage commitment in the immune system: the T helper lymphocyte grows up

2000 • 627 citations

The epidemic of allergy and asthma

1999 • 597 citations

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

2001 • 497 citations

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.

1998 • 450 citations

Attenuation of allergic airway inflammation in IL‐4 deficient mice

1994 • 433 citations

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

2000 • 412 citations

The molecular basis of T helper 1 and T helper 2 cell differentiation

2000 • 400 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1999 • 364 citations

Requirement for IL-13 independently of IL-4 in experimental asthma

1999 • 350 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

JunB suppresses cell proliferation by transcriptional activation of p16INK4a expression

2000 • 311 citations

The biology of Stat4 and Stat6

2000 • 310 citations

Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation

1998 • 304 citations

IL‐5‐induced airway eosinophilia – the key to asthma?

2001 • 301 citations

Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation

1999 • 285 citations

T1 and T2 CD4+ cells in human allergic diseases

1997 • 269 citations

JunB is essential for mammalian placentation

1999 • 261 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

1999 • 244 citations

Transcription

2002 • 241 citations

Treatment of Allergic Airway Inflammation and Hyperresponsiveness by Antisense-Induced Local Blockade of Gata-3 Expression

2001 • 239 citations

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage

2001 • 237 citations

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1998 • 228 citations

The trials and tribulations of IL-5, eosinophils, and allergic asthma

2001 • 209 citations

The Human Ubiquitin C Promoter Directs High Ubiquitous Expression of Transgenes in Mice

1996 • 203 citations

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

1996 • 200 citations

Th2-Induced Airway Mucus Production Is Dependent on IL-4Rα, But Not on Eosinophils

1999 • 192 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

Immune regulation in atopic dermatitis

2000 • 162 citations

JunB can substitute for Jun in mouse development and cell proliferation

2002 • 156 citations

The Cell Type-Specific Expression of the Murine IL-13 Gene Is Regulated by GATA-3

2001 • 152 citations

Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements

1995 • 137 citations

T Cells and Chronic Asthma

1999 • 127 citations

Reprogramming the signalling requirement for AP‐1 (activator protein‐1) activation during differentiation of precursor CD4⁺ T‐cells into effector Th1 and Th2 cells

1997 • 115 citations

Characterization of cis-Regulatory Elements and Nuclear Factors Conferring Th2-Specific Expression of the IL-5 Gene: A Role for a GATA-Binding Protein

1998 • 107 citations

In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis.

1999 • 93 citations

Cell Cycle Promoting Activity of JunB through Cyclin A Activation

2002 • 85 citations

In Vivo Inhibition of NF-κB in T-Lineage Cells Leads to a Dramatic Decrease in Cell Proliferation and Cytokine Production and to Increased Cell Apoptosis in Response to Mitogenic Stimuli, But Not to Abnormal Thymopoiesis

1999 • 79 citations

Identification of cis-Acting Regulatory Elements Controlling Interleukin-4 Gene Expression in T Cells: Roles for NF-Y and NF-AT_c

1993 • 62 citations

Bronchial asthma: Lessons from murine models

1997 • 60 citations

Immunoglobulin E and its regulators

2001 • 34 citations

Immunoglobulin E and its regulators

2001 • 29 citations

Overactivation of IL-4-induced activator protein-1 in atopic dermatitis

2002 • 19 citations

The cattle interleukin-13 gene: genomic organization, chromosomal location, and evolution of the promoter

1999 • 15 citations