c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

1998 • 454 citations

An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.

1996 • 384 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation

2000 • 374 citations

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors

1995 • 353 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

1999 • 305 citations

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

1996 • 300 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo

1984 • 296 citations

Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression

1995 • 289 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells

2000 • 283 citations

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses

1999 • 259 citations

Genomic and Biological Variation among Commonly Used Lymphocytic Choriomeningitis Virus Strains

1983 • 241 citations

CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-κB and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-κB-inducing Kinase

1998 • 239 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.

1996 • 219 citations

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

1995 • 172 citations

Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice

1998 • 163 citations

CD8 T cell memory in B cell-deficient mice.

1996 • 158 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70

1997 • 153 citations

Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses

2000 • 148 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation

2002 • 137 citations

c-Jun NH₂-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1

2000 • 130 citations

Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection

1998 • 126 citations

Role of CD40 Ligand and CD28 in Induction and Maintenance of Antiviral CD8+ Effector T Cell Responses

2000 • 126 citations

Virus-lymphocyte interactions IV. Molecular characterization of LCMV Armstrong (CTL+) small genomic segment and that of its variant, clone 13 (CTL−)

1988 • 118 citations

Minimal Bystander Activation of CD8 T Cells during the Virus-induced Polyclonal T Cell Response

1997 • 118 citations

Antigen-Specific Regulation of T Cell–Mediated Cytokine Production

2000 • 110 citations

Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system

1995 • 106 citations

Detection of a high frequency of virus-specific CD4+ T cells during acute infection with lymphocytic choriomeningitis virus.

1998 • 95 citations

Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation

2000 • 93 citations

Cutting Edge: Detection of a High Frequency of Virus-Specific CD4+ T Cells During Acute Infection with Lymphocytic Choriomeningitis Virus

1998 • 86 citations

Virus-lymphocyte interactions

1978 • 74 citations

The immune response of the mouse to lymphocytic choriomeningitis virus V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection

1987 • 72 citations

Lymphotoxin-β-Deficient Mice Show Defective Antiviral Immunity

1999 • 69 citations

JNK1 Is Required for T Cell-Mediated Immunity AgainstLeishmania majorInfection

2000 • 66 citations

Role of the Stress Kinase Pathway in Signaling Via the T Cell Costimulatory Receptor 4-1BB

1999 • 65 citations

The immune response of the mouse to lymphocytic choriomeningitis virus

1983 • 64 citations

Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains

1984 • 55 citations

High Frequency of Virus-Specific Interleukin-2-Producing CD4⁺T Cells and Th1 Dominance during Lymphocytic Choriomeningitis Virus Infection

2000 • 52 citations

Antiviral immune responses in CTLA4 transgenic mice

1997 • 51 citations

Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule

1992 • 49 citations

Activation of c-Jun N-terminal Kinase by 4-1BB (CD137), a T Cell Co-stimulatory Molecule

2000 • 14 citations

Immunocytotherapy

2002 • 9 citations