The regulation of IgA class switching

Toll-Like Receptors

2003 • 6,127 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

2007 • 2,524 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Predominant Autoantibody Production by Early Human B Cell Precursors

2003 • 1,966 citations

Germinal Centers

1994 • 1,680 citations

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

2000 • 1,604 citations

Interactions between commensal intestinal bacteria and the immune system

2004 • 1,540 citations

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

2004 • 1,520 citations

Mucosal immunity and vaccines

2005 • 1,459 citations

Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

2002 • 1,305 citations

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

2002 • 1,246 citations

Mucosal vaccines: the promise and the challenge

2006 • 1,118 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria

2000 • 1,085 citations

Mechanism and Regulation of Class Switch Recombination

2008 • 1,027 citations

BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells

2004 • 1,014 citations

Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells

2006 • 963 citations

The immune geography of IgA induction and function

2007 • 944 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

2001 • 889 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

2005 • 797 citations

Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

2004 • 788 citations

IgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis

2007 • 773 citations

PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR I<scp>G</scp>A-PRODUCING IMMUNOCYTES IN THE RABBIT

1971 • 756 citations

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

2003 • 712 citations

Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL

2007 • 702 citations

TACI is mutant in common variable immunodeficiency and IgA deficiency

2005 • 691 citations

Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

2006 • 677 citations

CD40/CD154 Interactions at the Interface of Tolerance and Immunity

2004 • 673 citations

Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans

2005 • 659 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.

1992 • 641 citations

Blood Dendritic Cells Interact with Splenic Marginal Zone B Cells to Initiate T-Independent Immune Responses

2002 • 619 citations

Extrafollicular antibody responses

2003 • 617 citations

Antibodies, viruses and vaccines

2002 • 616 citations

B cells acquire antigen from target cells after synapse formation

2001 • 606 citations

Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

2002 • 580 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

2004 • 567 citations

Identification and characterization of circulating human transitional B cells

2005 • 561 citations

B cell receptor signal strength determines B cell fate

2004 • 548 citations

TACI and BAFF-R mediate isotype switching in B cells

2005 • 523 citations

Regulation of the T-Independent Humoral Response by TACI

2001 • 513 citations

Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells

2006 • 500 citations

IgA Fc Receptors

2003 • 494 citations

Intestinal IgA synthesis: regulation of front-line body defences

2003 • 489 citations

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

2001 • 428 citations

T-Independent Immune Response: New Aspects of B Cell Biology

2000 • 413 citations

Autoreactivity by design: innate B and T lymphocytes

2001 • 409 citations

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

2001 • 405 citations

HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals

1997 • 403 citations

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

2000 • 403 citations

Secretory Component

2002 • 399 citations

Cell Surface Recycling of Internalized Antigen Permits Dendritic Cell Priming of B Cells

2005 • 386 citations

Mutations ofCD40gene cause an autosomal recessive form of immunodeficiency with hyper IgM

2001 • 379 citations

Mucosal and Glandular Distribution of Immunoglobulin Components: Differential Localization of Free and Bound SC in Secretory Epithelial Cells

1974 • 356 citations

Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity

1989 • 351 citations

Targeting of somatic hypermutation

2006 • 349 citations

The role of APRIL and BAFF in lymphocyte activation

2005 • 344 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

Identification of FcαRI as an Inhibitory Receptor that Controls Inflammation

2005 • 334 citations

Antibody Class Switching

1996 • 327 citations

Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells

2008 • 324 citations

Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA

1986 • 313 citations

An APRIL to remember: novel TNF ligands as therapeutic targets

2006 • 310 citations

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

1996 • 304 citations

Normal, Autoimmune, and Malignant CD5+ B Cells: The LY-1 B Lineage?

1988 • 302 citations

Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI

2007 • 297 citations

TGFβ signalling in control of T-cell-mediated self-reactivity

2007 • 294 citations

CpG DNA Induces IgG Class Switch DNA Recombination by Activating Human B Cells through an Innate Pathway That Requires TLR9 and Cooperates with IL-10

2004 • 292 citations

T cell independent antigens

1995 • 282 citations

Control of lymphocyte development by nuclear factor-κB

2005 • 271 citations

Mucosal immunoglobulins

2005 • 257 citations

Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues.

1986 • 252 citations

Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation

2000 • 250 citations

B cell memory and the long-lived plasma cell

1999 • 250 citations

Regulation of AID expression in the immune response

2007 • 250 citations

Immunoglobulin M and Secretory Immunoglobulin A: Presence of a Common Polypeptide Chain Different from Light Chains

1971 • 245 citations

Innate secretory antibodies protect against natural Salmonella typhimurium infection

2006 • 242 citations

CD11b+ Peyer’s Patch Dendritic Cells Secrete IL-6 and Induce IgA Secretion from Naive B Cells

2003 • 241 citations

Human Dendritic Cells Skew Isotype Switching of CD40-activated Naive B Cells towards IgA1 and IgA2

1997 • 241 citations

Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

1990 • 237 citations

CpG Drives Human Transitional B Cells to Terminal Differentiation and Production of Natural Antibodies

2008 • 236 citations

FcαRI-positive liver Kupffer cells: Reappraisal of the function of immunoglobulin A in immunity

2000 • 231 citations

Thymic stromal lymphopoietin in normal and pathogenic T cell development and function

2006 • 225 citations

CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM+IgD+ B Cell Line

1998 • 212 citations

High frequency class switching of an lgM⁺ B lymphoma clone CH12F3 to lgA⁺ cells

1996 • 212 citations

Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NF B

2004 • 205 citations

Immunoglobulin‐bearing B cells reconstitute and maintain the murine Ly‐1 B cell lineage

1986 • 205 citations

Signaling in B cells via Toll-like receptors

2005 • 203 citations

Mechanisms of divergence and convergence of the human immunoglobulin α1 and α2 constant region gene sequences

1984 • 195 citations

A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs

2001 • 169 citations

Anti-Inflammatory Role for Intracellular Dimeric Immunoglobulin A by Neutralization of Lipopolysaccharide in Epithelial Cells

2003 • 161 citations

CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination.

1998 • 161 citations

Regulating antigen-receptor gene assembly

2003 • 157 citations

Airway Epithelial Cells Produce B Cell-Activating Factor of TNF Family by an IFN-β-Dependent Mechanism

2006 • 156 citations

Gut IgA Class Switch Recombination in the Absence of CD40 Does Not Occur in the Lamina Propria and Is Independent of Germinal Centers

2006 • 153 citations

Coordinate regulation of cell growth and differentiation by TGF-β superfamily and Runx proteins

2004 • 152 citations

Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes

2000 • 148 citations

Immunity to Rotavirus in T Cell Deficient Mice

1997 • 147 citations

Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response

2007 • 146 citations

Regulation of antibody production and class switching by TGF-beta.

1995 • 141 citations

Transcriptional Regulation of the Transforming Growth Factor-β-inducible Mouse Germ Line Ig α Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members

2000 • 132 citations

CD40 Engagement Triggers Switching to IgA1 and IgA2 in Human B Cells Through Induction of Endogenous TGF-β: Evidence for TGF-β But Not IL-10-Dependent Direct Sμ→Sα and Sequential Sμ→Sγ, Sγ→Sα DNA Recombination

1998 • 126 citations

TGF-β1 induces germ-line transcripts of both IgA subclasses in human B lymphocytes

1991 • 123 citations

TACI regulates IgA production by APRIL in collaboration with HSPG

2006 • 123 citations

Novel in vitro model for high-rate IgA class switching.

1995 • 121 citations

Discovery of Activation‐Induced Cytidine Deaminase, the Engraver of Antibody Memory

2007 • 118 citations

B1 Cells Contribute to Serum IgM, But Not to Intestinal IgA, Production in Gnotobiotic Ig Allotype Chimeric Mice

2003 • 115 citations

Epithelia: lymphocyte interactions in the gut

2007 • 113 citations

Secretory IgA Possesses Intrinsic Modulatory Properties Stimulating Mucosal and Systemic Immune Responses

2005 • 109 citations

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter.

1998 • 105 citations

Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili

2005 • 104 citations

Differential Susceptibility of Human IgA Immunoglobulins to Streptococcal IgA Protease

1974 • 104 citations

Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene.

1991 • 103 citations

CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α Promoter

1998 • 97 citations

Smad3 and Smad4 mediate transforming growth factor-β1-induced IgA expression in murine B lymphocytes

2001 • 94 citations

Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation

2007 • 93 citations

Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements.

1992 • 93 citations

Switch circles from IL-4-directed epsilon class switching from human B lymphocytes. Evidence for direct, sequential, and multiple step sequential switch from mu to epsilon Ig heavy chain gene.

1994 • 88 citations

Restricted IgA Repertoire in Both B-1 and B-2 Cell-Derived Gut Plasmablasts

2005 • 88 citations

Enhanced IgA Class Switching in Marginal Zone and B1 B Cells Relative to Follicular/B2 B Cells

2006 • 87 citations

Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses

2006 • 78 citations

Dendritic Cells and Resting B Cells Form Clusters In Vitro and In Vivo: T Cell Independence, Partial LFA-1 Dependence, and Regulation by Cross-Linking Surface Molecules

1998 • 78 citations

BAFF costimulation of Toll‐like receptor‐activatedB‐1 cells

2006 • 78 citations

Ongoing In Vivo Immunoglobulin Class Switch DNA Recombination in Chronic Lymphocytic Leukemia B Cells

2002 • 76 citations

Intestinal B-cell isotype response in relation to local bacterial load: Evidence for immunoglobulin A subclass adaptation

1995 • 71 citations

Structure of TGF-β1-induced human immunoglobulin Cα1 and Cα2 germ-line transcripts

1991 • 61 citations

Plasma cell differentiation in T‐independent type 2 immune responses is independent of CD11c^high dendritic cells

2006 • 59 citations

Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line.

1998 • 49 citations

Vasoactive intestinal peptide induces S(alpha)/S(mu) switch circular DNA in human B cells.

1996 • 49 citations

AML and Ets proteins regulate the Iα1 germ-line promoter

1999 • 47 citations

Overexpression of BSAP/Pax-5 Inhibits Switching to IgA and Enhances Switching to IgE in the I.29μ B Cell Line

1998 • 45 citations

Two distinctive pathways for recruitment of naïve and primed IgM⁺B cells to the gut lamina propria

2005 • 43 citations

The Histone Methyltransferase Suv39h1 Increases Class Switch Recombination Specifically to IgA

2006 • 40 citations

B Cell-Specific Deficiency for Smad2 In Vivo Leads to Defects in TGF-β-Directed IgA Switching and Changes in B Cell Fate

2006 • 39 citations

Common variable immune deficiency: reviews, continued puzzles, and a new registry

2007 • 38 citations

Roles of Ets proteins, NF-κB and nocodazole in regulating induction of transcription of mouse germline Ig α RNA by transforming growth factor-β1

2001 • 37 citations

The Ubiquitously Expressed DNA-Binding Protein Late SV40 Factor Binds Ig Switch Regions and Represses Class Switching to IgA

2002 • 26 citations

Stimuli that enhance IgA class switching increase histone 3 acetylation at Sα, but poorly stimulate sequential switching from IgG2b

2006 • 23 citations