CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter.

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

1993 • 621 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

Molecular Cloning and Characterization of PEBP2β, the Heterodimeric Partner of a Novel Drosophila runt-Related DNA Binding Protein PEBP2α

1993 • 504 citations

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

1993 • 484 citations

Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex

1997 • 441 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

1994 • 403 citations

The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation

1995 • 391 citations

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

1996 • 382 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

Antibody Class Switching

1996 • 327 citations

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.

1991 • 324 citations

An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-β

1996 • 312 citations

TGF-β signalling through the Smad pathway

1997 • 265 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Switch Transcripts in Immunoglobulin Class Switching

1995 • 248 citations

The Tissue-Specific Nuclear Matrix Protein, NMP-2, Is a Member of the AML/PEBP2/Runt Domain Transcription Factor Family: Interactions with the Osteocalcin Gene Promoter

1995 • 245 citations

Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.

1993 • 229 citations

Cooperative binding of Ets-1 and core binding factor to DNA.

1994 • 216 citations

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

1994 • 214 citations

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

1993 • 206 citations

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.

1994 • 204 citations

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

1997 • 190 citations

Mechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures.

1990 • 183 citations

An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene.

1996 • 171 citations

A New Transcription Factor Family Associated with Human Leukemias

1995 • 164 citations

Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains

1998 • 163 citations

Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian Runt domain

1995 • 160 citations

Expression of the Runt Domain-Encoding PEBP2α Genes in T cells during Thymic Development

1995 • 160 citations

The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element.

1992 • 159 citations

Cell-specific Induction of Distinct Oncogenes of the Jun Family Is Responsible for Differential Regulation of Collagenase Gene Expression by Transforming Growth Factor-β in Fibroblasts and Keratinocytes

1996 • 157 citations

Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins

1995 • 153 citations

The preference for switching to IgA expression by Peyer's patch germinal center B cells is likely due to the intrinsic influence of their microenvironment.

1991 • 141 citations

Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

1990 • 138 citations

Role of the cytoskeleton in cell-to-cell transmission of human immunodeficiency virus

1994 • 137 citations

AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia.

1996 • 118 citations

Transforming Growth Factor βl-Responsive Element: Closely Associated Binding Sites for USF and CCAAT-Binding Transcription Factor-Nuclear Factor I in the Type 1 Plasminogen Activator Inhibitor Gene

1992 • 112 citations

Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene.

1991 • 103 citations

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes.

1985 • 99 citations

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer.

1992 • 98 citations

Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements.

1992 • 93 citations

Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA.

1988 • 91 citations

Activation of NF-κB/Rel by CD40 Engagement Induces the Mouse Germ Line Immunoglobulin Cγ1 Promoter

1996 • 85 citations

Indirect and Direct Disruption of Transcriptional Regulation in Cancer: E2F and AML-1

1995 • 61 citations

ETS-Core Binding Factor: a Common Composite Motif in Antigen Receptor Gene Enhancers

1998 • 61 citations

AML1 Is Expressed in Skeletal Muscle and Is Regulated by Innervation

1994 • 55 citations

Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores

1995 • 53 citations

Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line.

1998 • 49 citations

Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter

1995 • 47 citations

A ubiquitous repressor interacting with an F9 cell-specific silencer and its functional suppression by differentiated cell-specific positive factors.

1990 • 44 citations

Effect of downregulation of germline transcripts on immunoglobulin A isotype differentiation.

1993 • 39 citations

The human l_α1 and l_α2 germline promoter elements: proximal positive and distal negative elements may regulate the tissue specific expression of C_α1 and C_α2 germline transcripts

1993 • 39 citations

Differentiation in the murine B cell lymphoma I.29: individual μ⁺ clones may be induced by lipopolysaccharide to both IgM secretion and isotype switching

1987 • 31 citations

The human I_α1 region contains a TGF–β1 responsive enhancer and a putative recombination hotspot

1995 • 27 citations

Transcriptional regulation of the germline immunoglobulin C_α and C_ε genes: implications for commitment to an isotype switch

1992 • 9 citations