Stimuli that enhance IgA class switching increase histone 3 acetylation at Sα, but poorly stimulate sequential switching from IgG2b

Translating the Histone Code

2001 • 9,488 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

2002 • 1,246 citations

A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria

2000 • 1,085 citations

T Cell-Independent Antigens Type 2

1995 • 798 citations

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

2003 • 723 citations

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

2003 • 712 citations

TACI is mutant in common variable immunodeficiency and IgA deficiency

2005 • 691 citations

Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans

2005 • 659 citations

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

2004 • 567 citations

TACI and BAFF-R mediate isotype switching in B cells

2005 • 523 citations

Regulation of the T-Independent Humoral Response by TACI

2001 • 513 citations

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

2001 • 496 citations

Mismatch Recognition and Uracil Excision Provide Complementary Paths to Both Ig Switching and the A/T-Focused Phase of Somatic Mutation

2004 • 456 citations

Interaction and Functional Cooperation of PEBP2/CBF with Smads

1999 • 449 citations

Impaired IgA class switching in APRIL-deficient mice

2004 • 431 citations

Chromatin Higher Order Folding--Wrapping up Transcription

2002 • 422 citations

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

2000 • 403 citations

Mechanism and control of class-switch recombination

2002 • 379 citations

Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity

1989 • 351 citations

Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin

2003 • 269 citations

Signaling pathways in Th2 development

2004 • 258 citations

Mucosal immunoglobulins

2005 • 257 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes

1999 • 218 citations

Stepwise activation of the immunoglobulin micro heavy chain gene locus

2001 • 210 citations

Molecular Processes that Regulate Class Switching

2000 • 202 citations

Mechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures.

1990 • 183 citations

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

2005 • 174 citations

Transforming growth factor beta 1 increases IgA isotype switching at the clonal level.

1990 • 150 citations

Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes

2000 • 148 citations

TGF-β Receptor Signaling Is Critical for Mucosal IgA Responses

2004 • 145 citations

Switching to IgG3, IgG2b, and IgA Is Division Linked and Independent, Revealing a Stochastic Framework for Describing Differentiation

1999 • 141 citations

Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

1990 • 138 citations

Transcriptional Regulation of the Transforming Growth Factor-β-inducible Mouse Germ Line Ig α Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members

2000 • 132 citations

Transient IL-7/IL-7R Signaling Provides a Mechanism for Feedback Inhibition of Immunoglobulin Heavy Chain Gene Rearrangements

2003 • 121 citations

Novel in vitro model for high-rate IgA class switching.

1995 • 121 citations

Further studies of the role of transforming growth factor-beta in human B cell function.

1989 • 108 citations

Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.

1999 • 107 citations

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter.

1998 • 105 citations

Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues.

1999 • 99 citations

Partial IgA-Deficiency with Increased Th2-Type Cytokines in TGF-β1 Knockout Mice

1999 • 98 citations

CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α Promoter

1998 • 97 citations

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination

2005 • 97 citations

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S in Ig class switch recombination

2004 • 95 citations

The Radioprotective 105/MD-1 Complex Links TLR2 and TLR4/MD-2 in Antibody Response to Microbial Membranes

2005 • 92 citations

IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination.

1996 • 90 citations

Enhanced IgA Class Switching in Marginal Zone and B1 B Cells Relative to Follicular/B2 B Cells

2006 • 87 citations

B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline CH transcription and Ig class switching.

1997 • 85 citations

AID-dependent histone acetylation is detected in immunoglobulin S regions

2006 • 83 citations

Deficiency of IL-5 Receptor α-Chain Selectively Influences the Development of the Common Mucosal Immune System Independent IgA-Producing B-1 Cell in Mucosa-Associated Tissues

1999 • 79 citations

Decision criteria for resolving isotype switching conflicts by B cells

2005 • 75 citations

Differential regulation of IgA production by TGF-β and IL-5: TGF-β induces surface IgA-positive cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells

1992 • 74 citations

Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide.

1992 • 57 citations

Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching

2004 • 54 citations

B Cell-Specific Deficiency for Smad2 In Vivo Leads to Defects in TGF-β-Directed IgA Switching and Changes in B Cell Fate

2006 • 39 citations

Analysis of transforming growth factor‐β1‐induced Ig germ‐line γ2b transcription and its implication for IgA isotype switching

2005 • 39 citations

Iα exon-replacement mice synthesize a spliced HPRT–Cα transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice

1999 • 38 citations

Interallelic Class Switch Recombination Contributes Significantly to Class Switching in Mouse B Cells

2005 • 35 citations