Extrafollicular antibody responses

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Germinal Centers

1994 • 1,680 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

2002 • 1,246 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program

2002 • 1,000 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

A Critical Role for IL-21 in Regulating Immunoglobulin Production

2002 • 955 citations

Marginal Zone and B1 B Cells Unite in the Early Response against T-Independent Blood-Borne Particulate Antigens

2001 • 955 citations

Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo

2001 • 942 citations

T Cell-Independent Antigens Type 2

1995 • 798 citations

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

1998 • 762 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

BAFF: A fundamental survival factor for B cells

2002 • 694 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

2004 • 648 citations

A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements

2001 • 620 citations

Blood Dendritic Cells Interact with Splenic Marginal Zone B Cells to Initiate T-Independent Immune Responses

2002 • 619 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

2002 • 558 citations

Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers

2002 • 522 citations

Regulation of the T-Independent Humoral Response by TACI

2001 • 513 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response

1998 • 454 citations

B‐cell activation by T‐cell‐independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms

2000 • 452 citations

Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas.

1980 • 432 citations

SAP is required for generating long-term humoral immunity

2003 • 419 citations

Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses

1997 • 417 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

Human marginal-zone B cells

1998 • 408 citations

Regulatory Mechanisms that Determine the Development and Function of Plasma Cells

2003 • 364 citations

IgMhighCD21high Lymphocytes Enriched in the Splenic Marginal Zone Generate Effector Cells More Rapidly Than the Bulk of Follicular B Cells

1999 • 364 citations

The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation.

1981 • 359 citations

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2

1995 • 358 citations

Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84

2010 • 357 citations

Chemotactic Responsiveness Toward Ligands for CXCR3 and CXCR4 Is Regulated on Plasma Blasts During the Time Course of a Memory Immune Response

2002 • 352 citations

Positive Selection from Newly Formed to Marginal Zone B Cells Depends on the Rate of Clonal Production, CD19, and btk

2000 • 349 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

The phenotype and fate of the antibody‐forming cells of the splenic foci

1996 • 340 citations

Evidence for a Large Compartment of IgM-Expressing Memory B Cells in Humans

1997 • 329 citations

SINGLE CELL STUDIES ON 19S ANTIBODY PRODUCTION

1964 • 317 citations

Long-lived plasma cells: a mechanism for maintaining persistent antibody production

1998 • 312 citations

Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival

2000 • 311 citations

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

2002 • 297 citations

The changing preference of T and B cells for partners as T‐dependent antibody responses develop

1997 • 292 citations

Germinal Centers without T Cells

2000 • 292 citations

Role of BCR affinity in T cell–dependent antibody responses in vivo

2002 • 288 citations

Distinct short‐lived and long‐lived antibody‐producing cell populations

1986 • 276 citations

Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zones

1988 • 272 citations

The AID enzyme induces class switch recombination in fibroblasts

2002 • 267 citations

Comparative migration of B- and T-lymphocytes in the rat spleen and lymph nodes

1976 • 267 citations

Arrested Differentiation, the Self-Renewing Memory Lymphocyte, and Vaccination

2001 • 264 citations

Immaturity of the human splenic marginal zone in infancy. Possible contribution to the deficient infant immune response.

1989 • 252 citations

Switch Transcripts in Immunoglobulin Class Switching

1995 • 248 citations

T Helper 1 (Th1) and Th2 Characteristics Start to Develop During T Cell Priming and Are Associated with an Immediate Ability to Induce Immunoglobulin Class Switching

1998 • 235 citations

Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cells

2001 • 229 citations

B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells

2003 • 223 citations

Humoral immunity and long-lived plasma cells

2002 • 214 citations

Impaired clearance of dying cells in systemic lupus erythematosus

2004 • 209 citations

A Quasi-Monoclonal Mouse

1996 • 204 citations

Immunoglobulin switch transcript production in vivo related to the site and time of antigen-specific B cell activation.

1996 • 199 citations

Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

2002 • 188 citations

B‐lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays

2000 • 186 citations

Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice

1974 • 168 citations

Marginal zones: the major B cell compartment of rat spleens

1981 • 163 citations

Migrant μ⁺δ⁺ and static μ⁺δ⁻ B lymphocyte subsets

1982 • 159 citations

Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6

1997 • 159 citations

Visualization of the Genesis and Fate of Isotype-switched B Cells during a Primary Immune Response

2003 • 145 citations

Dendritic cells associated with plasmablast survival

1999 • 144 citations

Plasmodium chabaudi chabaudi Infection in Mice Induces Strong B Cell Responses and Striking But Temporary Changes in Splenic Cell Distribution

2003 • 133 citations

Serum immunoglobulin levels and naturally occurring antibodies against carbohydrate antigens in germ‐free BALB/c mice fed chemically defined ultrafiltered diet

1989 • 133 citations

T-independent type 2 antigens induce B cell proliferation in multiple splenic sites, but exponential growth is confined to extrafollicular foci

1999 • 122 citations

Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes

2001 • 122 citations

Sequential antigen‐specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c

1996 • 116 citations

SH2D1A Regulates T-dependent Humoral Autoimmunity

2004 • 115 citations

In Vitro Responses of CBA/N Mice: Spleen Cells of Mice with an X-Linked Defect that Precludes Immune Responses to Several Thymus-Independent Antigens Can Respond to TNP-Lipopolysaccharide

1976 • 113 citations

CDK Inhibitor p18INK4c Is Required for the Generation of Functional Plasma Cells

2002 • 106 citations

Cells of the marginal zone of the spleen are lymphocytes derived from recirculating precursors

1981 • 105 citations

Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production

1997 • 102 citations

Repression of c-mycIs Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro

2000 • 100 citations

Differences in the recruitment of virgin B cells into antibody responses to thymus‐dependent and thymus‐independent type‐2 antigens

1986 • 99 citations

Short-circuiting long-lived humoral immunity by the heightened engagement of CD40

2002 • 95 citations

Mechanism of BLyS action in B cell immunity

2002 • 89 citations

Cutting Edge: Germinal Centers Can Be Induced in the Absence of T Cells

2001 • 84 citations

Short-circuiting long-lived humoral immunity by the heightened engagement of CD40

2002 • 80 citations

Virgin B cell recruitment and the lifespan of memory clones during antibody responses to 2,4‐dinitrophenyl‐hemocyanin

1986 • 75 citations

Newly produced virgin B cells migrate to secondary lymphoid organs but their capacity to enter follicles is restricted

1987 • 75 citations

Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens

2003 • 73 citations

Partial biochemical characterization of IgG₁‐inducing factor

1985 • 69 citations

Sequence analysis of rearranged IgVH genes from microdissected human Peyer's patch marginal zone B cells.

1996 • 65 citations

B-cell receptor regulation of peripheral B cells

1998 • 58 citations

Th2 Activities Induced During Virgin T Cell Priming in the Absence of IL-4, IL-13, and B Cells

2002 • 49 citations

Tracking the response of Xid B cells in vivo: TI-2 antigen induces migration and proliferation but Btk is essential for terminal differentiation

2001 • 47 citations

The B-Lymphocyte Maturation Promoting Transcription Factor BLIMP1/PRDI-BF1 Maps to D6S447 on Human Chromosome 6q21–q22.1 and the Syntenic Region of Mouse Chromosome 10

1996 • 46 citations

B-cell production and differentiation in adult rats.

1985 • 46 citations

The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection.

1996 • 45 citations

Anti-CD40 antibody enhances responses to polysaccharide without mimicking T cell help

1999 • 44 citations

Rescue of self-reactive B cells by provision of T cell helpin vivo

1998 • 43 citations

BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially

2002 • 42 citations

B cell repertoire in adult antigen‐free and conventional neonatal balb/c mice

1989 • 38 citations

B cell repertoire in adult antigen‐free and conventional neonatal balb/c mice

1989 • 33 citations

The Natural History of the Cells Producing IgA in the Gut

1976 • 33 citations

Early neutralizing antibody response against mouse mammary tumor virus: critical role of viral infection and superantigen-reactive T cells.

1997 • 32 citations

The clinical spectrum of bruton’s agammaglobulinemia

2001 • 30 citations

The Generation of B-Cell Memory: A Working Hypothesis

1990 • 25 citations

Analysis of B Cell Memory Formation Using DNA Microarrays

2002 • 20 citations

Long-lived Plasma Cells Survive Independent of Antigen

1999 • 19 citations

A Dual Origin for IgA Plasma Cells in the Murine Small Intestine

1995 • 11 citations