Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL

Toll-Like Receptors

2003 • 6,127 citations

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

2004 • 4,044 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

2004 • 1,520 citations

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

2002 • 1,246 citations

Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells

2006 • 963 citations

Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

2005 • 797 citations

Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

2004 • 788 citations

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

2006 • 725 citations

Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans

2005 • 659 citations

Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation

2002 • 583 citations

Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

2002 • 580 citations

TLR Signaling in the Gut in Health and Disease

2005 • 578 citations

Collaboration of epithelial cells with organized mucosal lymphoid tissues

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Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

2004 • 567 citations

TACI and BAFF-R mediate isotype switching in B cells

2005 • 523 citations

Intestinal IgA synthesis: regulation of front-line body defences

2003 • 489 citations

Impaired IgA class switching in APRIL-deficient mice

2004 • 431 citations

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

2001 • 428 citations

Mutations ofCD40gene cause an autosomal recessive form of immunodeficiency with hyper IgM

2001 • 379 citations

Man the barrier! strategic defences in the intestinal mucosa

2001 • 362 citations

Targeting of somatic hypermutation

2006 • 349 citations

The role of APRIL and BAFF in lymphocyte activation

2005 • 344 citations

Antibody Class Switching

1996 • 327 citations

Plasma cells: finding new light at the end of B cell development

2001 • 305 citations

Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI

2007 • 297 citations

CpG DNA Induces IgG Class Switch DNA Recombination by Activating Human B Cells through an Innate Pathway That Requires TLR9 and Cooperates with IL-10

2004 • 292 citations

Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues.

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CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

CD11b+ Peyer’s Patch Dendritic Cells Secrete IL-6 and Induce IgA Secretion from Naive B Cells

2003 • 241 citations

Human Dendritic Cells Skew Isotype Switching of CD40-activated Naive B Cells towards IgA1 and IgA2

1997 • 241 citations

Distribution of IgA1-, IgA2-, and J chain-containing cells in human tissues.

1984 • 232 citations

Thymic stromal lymphopoietin in normal and pathogenic T cell development and function

2006 • 225 citations

Intestinal IgA: novel views on its function in the defence of the largest mucosal surface

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CCL28 Controls Immunoglobulin (Ig)A Plasma Cell Accumulation in the Lactating Mammary Gland and IgA Antibody Transfer to the Neonate

2004 • 204 citations

Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells

2006 • 168 citations

Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies.

1988 • 160 citations

Regulating antigen-receptor gene assembly

2003 • 157 citations

Airway Epithelial Cells Produce B Cell-Activating Factor of TNF Family by an IFN-β-Dependent Mechanism

2006 • 156 citations

Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses.

1990 • 114 citations

Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation

2004 • 86 citations

Ongoing In Vivo Immunoglobulin Class Switch DNA Recombination in Chronic Lymphocytic Leukemia B Cells

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HIV infection: first battle decides the war

2006 • 76 citations

IgA Adaptation to the Presence of Commensal Bacteria in the Intestine

2006 • 55 citations

Two distinctive pathways for recruitment of naïve and primed IgM⁺B cells to the gut lamina propria

2005 • 43 citations