Ongoing In Vivo Immunoglobulin Class Switch DNA Recombination in Chronic Lymphocytic Leukemia B Cells

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

Germinal Centers

1994 • 1,680 citations

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

2002 • 1,246 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

1998 • 1,145 citations

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

2001 • 1,110 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells

2001 • 934 citations

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1998 • 899 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease

2002 • 643 citations

Mutation ofBCL-6Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

1998 • 536 citations

Human Lymphocytes Making Rheumatoid Factor and Antibody to ssDNA Belong to Leu-1⁺B-Cell Subset

1987 • 490 citations

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

2001 • 428 citations

T-Independent Immune Response: New Aspects of B Cell Biology

2000 • 413 citations

B-Cell Chronic Lymphocytic Leukemia: A Bird of a Different Feather

1999 • 408 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

Mechanism and control of class-switch recombination

2002 • 379 citations

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2

1995 • 358 citations

B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

2002 • 358 citations

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

2001 • 350 citations

The CD5 B Cell

1989 • 327 citations

Within Germinal Centers, Isotype Switching of Immunoglobulin Genes Occurs after the Onset of Somatic Mutation

1996 • 310 citations

The BCL11 gene family: involvement of BCL11A in lymphoid malignancies

2001 • 306 citations

Modulation of NF-κB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells

2000 • 278 citations

The AID enzyme induces class switch recombination in fibroblasts

2002 • 267 citations

Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22

2002 • 266 citations

Circular DNA is excised by immunoglobulin class switch recombination

1990 • 244 citations

Differential Rates of Somatic Hypermutation in VH Genes Among Subsets of Chronic Lymphocytic Leukemia Defined by Chromosomal Abnormalities

1997 • 237 citations

The Immunoglobulin Class Switch: Beyond “Accessibility”

1997 • 217 citations

CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM+IgD+ B Cell Line

1998 • 212 citations

Acquired CD40-ligand deficiency in chronic lymphocytic leukemia

1997 • 206 citations

The Translesion DNA Polymerase ζ Plays a Major Role in Ig and bcl-6 Somatic Hypermutation

2001 • 205 citations

Survival of leukemic B cells promoted by engagement of the antigen receptor

2001 • 200 citations

Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

2002 • 188 citations

AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

2002 • 185 citations

Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.

1988 • 177 citations

A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs

2001 • 169 citations

CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination.

1998 • 161 citations

Reactive Plasmacytoses Are Expansions of Plasmablasts Retaining the Capacity to Differentiate Into Plasma Cells

1999 • 157 citations

Regulation of Expression of IL-4 Alleles

2001 • 147 citations

Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes.

1993 • 145 citations

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 145 citations

Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts.

1996 • 142 citations

Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells.

1995 • 137 citations

Origin of the Hodgkin/Reed-Sternberg Cells in Chronic Lymphocytic Leukemia With “Hodgkin's Transformation”

1998 • 136 citations

Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells.

1994 • 135 citations

Hodgkin and Reed-Sternberg–like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell–derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease

2000 • 135 citations

Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors.

1993 • 129 citations

CD40 Engagement Triggers Switching to IgA1 and IgA2 in Human B Cells Through Induction of Endogenous TGF-β: Evidence for TGF-β But Not IL-10-Dependent Direct Sμ→Sα and Sequential Sμ→Sγ, Sγ→Sα DNA Recombination

1998 • 126 citations

Reactive Plasmacytoses Are Expansions of Plasmablasts Retaining the Capacity to Differentiate Into Plasma Cells

1999 • 122 citations

Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin VHDJH Gene Diversification

2002 • 98 citations

Engagement of CD153 (CD30 Ligand) by CD30+ T Cells Inhibits Class Switch DNA Recombination and Antibody Production in Human IgD+ IgM+ B Cells

2000 • 97 citations

Differential Effect of B Lymphocyte–induced Maturation Protein (Blimp-1) Expression on Cell Fate during B Cell Development

1998 • 90 citations

Suppressor T cells: Rebirth, function and homeostasis

2000 • 80 citations

CD30 Is a CD40-Inducible Molecule that Negatively Regulates CD40-Mediated Immunoglobulin Class Switching in Non-Antigen-Selected Human B Cells

1998 • 78 citations

Associated chronic lymphocytic leukemia and multiple myeloma: origin from a single clone

1985 • 64 citations

BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia.

2000 • 61 citations

Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation.

1989 • 59 citations

Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.

1996 • 59 citations

The CD5/CD72 receptor system is coexpressed with several functionally relevant counterstructures on human B cells and delivers a critical signaling activity.

1996 • 56 citations

B-chronic lymphocytic leukemias can undergo isotype switching in vivo and can be induced to differentiate and switch in vitro [see comments]

1996 • 53 citations

IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

1996 • 52 citations

The evolutionarily conserved sequence upstream of the human Ig heavy chain S gamma 3 region is an inducible promoter: synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites.

1999 • 50 citations

Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia

2000 • 50 citations

Analysis with antiidiotype antibody of a patient with chronic lymphocytic leukemia and a large cell lymphoma (Richter's syndrome)

1987 • 49 citations

Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia.

1993 • 47 citations

Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells

2001 • 47 citations

Isotype switching in human B lymphocyte malignancies occurs by DNA deletion: evidence for nonspecific switch recombination.

1987 • 46 citations

High incidence of serum monoclonal Igs detected by a sensitive immunoblotting technique in B-cell chronic lymphocytic leukemia

1994 • 45 citations

Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification

1996 • 42 citations

The Evolutionarily Conserved Sequence Upstream of the Human Ig Heavy Chain Sγ3 Region Is an Inducible Promoter: Synergistic Activation by CD40 Ligand and IL-4 Via Cooperative NF-κB and STAT-6 Binding Sites

1999 • 41 citations

Richter's syndrome in a case of atypical chronic lymphocytic leukaemia with the t(11;14)(q13;q32): role for a p53 exon 7 gene mutation

1996 • 41 citations

Lack of Intraclonal Diversification in Ig Heavy and Light Chain V Region Genes Expressed by CD5+IgM+ Chronic Lymphocytic Leukemia B Cells: A Multiple Time Point Analysis

1998 • 35 citations

Histological and Immunoglobulin VH Gene Analysis of Interfollicular Small Lymphocytic Lymphoma Provides Evidence for Two Types

2000 • 35 citations

Identification of a tonsil IgD⁺ B cell subset with phenotypical and functional characteristics of germinal center B cells

1996 • 32 citations

Lack of somatic hypermutation of IG VH genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene

2002 • 30 citations

Lineage and stage specificity of isotype switching in humans.

1988 • 9 citations

Analysis with antiidiotype antibody of a patient with chronic lymphocytic leukemia and a large cell lymphoma (Richter's syndrome)

1987 • 5 citations

Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia

2000 • 4 citations