Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

1963 • 2,742 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

2003 • 1,115 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily

2002 • 770 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

Apoptosis in podocytes induced by TGF-β and Smad7

2001 • 574 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

The plasma membrane

1983 • 561 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

A role for Smad6 in development and homeostasis of the cardiovascular system

2000 • 488 citations

A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells

1996 • 479 citations

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

1999 • 475 citations

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

1998 • 469 citations

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

2000 • 455 citations

Interaction and Functional Cooperation of PEBP2/CBF with Smads

1999 • 449 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

2000 • 403 citations

A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelA

2000 • 397 citations

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5

1999 • 394 citations

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

2002 • 391 citations

The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

1998 • 390 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1998 • 368 citations

Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.

2000 • 364 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2

1998 • 295 citations

Non-injection methods for the production of embryonic stem cell-embryo chimaeras

1993 • 286 citations

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

2002 • 235 citations

Differential Inhibition of Smad6 and Smad7 on Bone Morphogenetic Protein- and Activin-mediated Growth Arrest and Apoptosis in B Cells

1999 • 225 citations

The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling

2001 • 221 citations

Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles

1998 • 209 citations

Molecular Processes that Regulate Class Switching

2000 • 202 citations

Smurf1 Regulates the Inhibitory Activity of Smad7 by Targeting Smad7 to the Plasma Membrane

2002 • 195 citations

Targeted Mutagenesis of Smad1 Reveals an Essential Role in Chorioallantoic Fusion

2001 • 181 citations

The role of TGF-β in growth, differentiation, and maturation of B lymphocytes

1999 • 148 citations

Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes

2000 • 148 citations

Smad7 Is an Activin-inducible Inhibitor of Activin-induced Growth Arrest and Apoptosis in Mouse B Cells

1998 • 139 citations

Smad7 mediates apoptosis induced by transforming growth factor β in prostatic carcinoma cells

2000 • 135 citations

Multiple roles of mouse Numb in tuning developmental cell fates

2001 • 131 citations

Smad7 inhibits the survival nuclear factor κB and potentiates apoptosis in epithelial cells

2001 • 110 citations

Smad7 Is Induced by CD40 and Protects WEHI 231 B-lymphocytes from Transforming Growth Factor-β-induced Growth Inhibition and Apoptosis

2000 • 86 citations

Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B cells in vitro.

1993 • 73 citations

Smad7 mediates transforming growth factor-β–induced apoptosis in mesangial cells

2002 • 56 citations

Transforming growth factor- - and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis

2003 • 36 citations

Dissection of inhibitory Smad proteins: both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7

2001 • 34 citations

Lipopolysaccharide Protects Primary B Lymphocytes from Apoptosis by Preventing Mitochondrial Dysfunction and Bax Translocation to Mitochondria

2004 • 20 citations

T-Cell Cytotoxicity Assays for Studying the Functional Interaction Between the Superantigen Staphylococcal Enterotoxin A and T-Cell Receptors

2003 • 10 citations